Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis (Q28366650)

2

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T Hanada

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T Wakioka

4

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M Oishi

5

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K Miyoshi

6

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S Komiya

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K Kosai

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Y Hanakawa

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K Hashimoto

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K Nagata

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A Yoshimura

Journal of Clinical Investigation

12

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language of work or name

English

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publication date

December 2001

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published in

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volume

108

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issue

12

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page(s)

1781-8

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cites work

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SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130

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Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain

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Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor alpha (cA2) versus placebo in rheumatoid arthritis

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Suppression of arthritic bone destruction by adenovirus-mediated csk gene transfer to synoviocytes and osteoclasts

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Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130

29 September 2017

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Interleukin 6 is required for the development of collagen-induced arthritis

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A central role for Stat3 in IL-6-induced regulation of growth and differentiation in M1 leukemia cells

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29 September 2017

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Induction of the p16INK4a senescence gene as a new therapeutic strategy for the treatment of rheumatoid arthritis

29 September 2017

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2 June 2018

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Restraint stress-induced immunosuppression by inhibiting leukocyte migration and Th1 cytokine expression during the intraperitoneal infection of Listeria monocytogenes.

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Repeated therapy with monoclonal antibody to tumour necrosis factor alpha (cA2) in patients with rheumatoid arthritis

27 November 2018

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27 November 2018

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12 December 2020

Therapy of rheumatoid arthritis by blocking IL-6 signal transduction with a humanized anti-IL-6 receptor antibody

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12 December 2020

Interleukin-10 (IL-10) selectively enhances CIS3/SOCS3 mRNA expression in human neutrophils: evidence for an IL-10-induced pathway that is independent of STAT protein activation

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12 December 2020

Interleukin 6 knock-out mice are resistant to antigen-induced experimental arthritis

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12 December 2020

Activation of the IL-4 STAT pathway in rheumatoid synovium

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12 December 2020

Humanized antibody to human interleukin-6 receptor inhibits the development of collagen arthritis in cynomolgus monkeys

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12 December 2020

Treatment of severe rheumatoid arthritis by anti-interleukin 6 monoclonal antibody

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12 December 2020

Interleukin-6 (IL-6) induces the proliferation of synovial fibroblastic cells in the presence of soluble IL-6 receptor

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Adenovirus gene transfer causes inflammation in the brain

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12 December 2020