Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130 (Q35777741)

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7 November 2019

title

Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130 (English)

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7 November 2019

2

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Louis Fabri

3

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7 November 2019

Doug Hilton

12

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Nicos A. Nicola

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D Metcalf

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7 November 2019

author name string

S E Nicholson

1

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7 November 2019

J Corbin

4

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T A Willson

5

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J G Zhang

6

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A Silva

7

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M Asimakis

8

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7 November 2019

A Farley

9

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A D Nash

10

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M Baca

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language of work or name

English

0 references

publication date

1 June 2000

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Proceedings of the National Academy of Sciences of the United States of America

7 November 2019

published in

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7 November 2019

volume

97

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issue

12

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7 November 2019

page(s)

6493-6498

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Inhibitory roles for SHP-1 and SOCS-3 following pituitary proopiomelanocortin induction by leukemia inhibitory factor

7 November 2019

cites work

1 reference

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SOCS3 is essential in the regulation of fetal liver erythropoiesis

27 July 2018

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Inhibition and restoration of prolactin signal transduction by suppressors of cytokine signaling

27 July 2018

1 reference

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Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain

27 July 2018

1 reference

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SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation

27 July 2018

1 reference

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Suppression of SHP-2 and ERK signalling promotes self-renewal of mouse embryonic stem cells.

27 July 2018

1 reference

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Activation of SOCS-3 messenger ribonucleic acid in the hypothalamus by ciliary neurotrophic factor

27 July 2018

1 reference

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The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop

27 July 2018

1 reference

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The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

27 July 2018

1 reference

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Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18633

The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18633

Activation of the protein tyrosine phosphatase SHP2 via the interleukin-6 signal transducing receptor protein gp130 requires tyrosine kinase Jak1 and limits acute-phase protein expression

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18633

Three distinct domains of SSI-1/SOCS-1/JAB protein are required for its suppression of interleukin 6 signaling

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18633

Identification of SOCS-3 as a potential mediator of central leptin resistance

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18633

Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with Ob receptor

27 July 2018

1 reference

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Jaks and STATs: biological implications

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18633

Growth hormone preferentially induces the rapid, transient expression of SOCS-3, a novel inhibitor of cytokine receptor signaling

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18633

Transcriptional regulation of vav, a gene expressed throughout the hematopoietic compartment

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18633

Twenty proteins containing a C-terminal SOCS box form five structural classes

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18633

The protein tyrosine phosphatase SHP-2 negatively regulates ciliary neurotrophic factor induction of gene expression

27 July 2018

1 reference

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A new protein containing an SH2 domain that inhibits JAK kinases

27 July 2018

1 reference

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A family of cytokine-inducible inhibitors of signalling

27 July 2018

1 reference

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Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: involvement of STAT3 in anti-apoptosis.

27 July 2018

1 reference

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Use of a biosensor with surface plasmon resonance detection for the determination of binding constants: measurement of interleukin-6 binding to the soluble interleukin-6 receptor.

27 July 2018

1 reference

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Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18633

SH2 domains recognize specific phosphopeptide sequences

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18633

Measurement of the binding of tyrosyl phosphopeptides to SH2 domains: a reappraisal

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18633

Direct determination of the sequence recognition requirements of the SH2 domains of SH-PTP2

27 July 2018

1 reference

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Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18633

Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18633

Dissection of signaling cascades through gp130 in vivo: reciprocal roles for STAT3- and SHP2-mediated signals in immune responses.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18633

Negative regulators of cytokine signal transduction

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18633

Interleukin-11 stimulates proopiomelanocortin gene expression and adrenocorticotropin secretion in corticotroph cells: evidence for a redundant cytokine network in the hypothalamo-pituitary-adrenal axis

25 September 2018

1 reference

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Mechanism of inhibition of growth hormone receptor signaling by suppressor of cytokine signaling proteins

25 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/10829066

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The specificity of the N-terminal SH2 domain of SHP-2 is modified by a single point mutation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/10829066

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

CIS3 and JAB have different regulatory roles in interleukin-6 mediated differentiation and STAT3 activation in M1 leukemia cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/10829066

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.100135197

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10829066%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10829066%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

1 reference