Ro 09-1470 is a selective inhibitor of P-450 lanosterol C-14 demethylase of fungi (Q28369539)

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F Yoshihara

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M Kondoh

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Y Nakamura

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N Nakayama

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M Arisawa

Antimicrobial Agents and Chemotherapy

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language of work or name

English

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publication date

December 1993

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published in

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volume

37

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issue

12

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page(s)

2662-7

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cites work

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Involvement of cytochrome P-450 and a cyanide-sensitive enzyme in different steps of lanosterol demethylation by yeast microsomes

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Isolation of the gene for cytochrome P450L1A1 (lanosterol 14 alpha-demethylase) from Candida albicans.

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A new series of natural antifungals that inhibit P450 lanosterol C-14 demethylase. I. Taxonomy, fermentation, isolation and structural elucidation

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Cytochrome P-450-dependent oxidation of lanosterol in cholesterol biosynthesis. Microsomal electron transport and C-32 demethylation

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12 December 2020

Metabolism of 32-hydroxy-24,25-dihydrolanosterol by purified cytochrome P-45014DM from yeast. Evidence for contribution of the cytochrome to whole process of lanosterol 14 alpha-demethylation

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Yeast cytochrome P-450 catalyzing lanosterol 14 alpha-demethylation. II. Lanosterol metabolism by purified P-450(14)DM and by intact microsomes

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Identification of lanosterol 14 alpha-methyl demethylase in human tissues

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Molecular dimensions of the substrate binding site of cytochrome P-448

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Spectral and kinetic studies of the interaction of imidazole anti-fungal agents with microsomal cytochromes P-450

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Evidence for the presence of cytochrome P-450 functional in lanosterol 14α-demethylation in microsomes of aerobically grown respiring yeast

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A new series of natural antifungals that inhibit P450 lanosterol C-14 demethylase. II. Mode of action

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Spectrophotometric examination of exogenous-ligand complexes of ferric cytochrome P-450. Characterization of the axial ligand trans to thiolate in the native ferric low-spin form

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Interaction of azole antifungal agents with cytochrome P-45014DM purified from Saccharomyces cerevisiae microsomes

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Comparison of two azole antifungal drugs, ketoconazole, and fluconazole, as modifiers of rat hepatic monooxygenase activity

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12 December 2020