Expression cloning of protein targets for 3-phosphorylated phosphoinositides (Q28377996)

2

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J Chen

3

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J Peng

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J Yuan

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G D Prestwich

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J S Brugge

Journal of Biological Chemistry

7

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language of work or name

English

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publication date

31 December 1999

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published in

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volume

274

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issue

53

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page(s)

37893-900

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cites work

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Using structure to define the function of phosphoinositide 3-kinase family members

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EEA1 links PI(3)K function to Rab5 regulation of endosome fusion

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Inositol lipid 5-phosphatases--traffic signals and signal traffic.

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A type II phosphoinositide 3-kinase is stimulated via activated integrin in platelets. A source of phosphatidylinositol 3-phosphate

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Phosphatidylinositol-4-phosphate 5-kinase isozymes catalyze the synthesis of 3-phosphate-containing phosphatidylinositol signaling molecules

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Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB.

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Regulation of neuronal survival by the serine-threonine protein kinase Akt

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The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

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Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

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4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway

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Phosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation

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Conditional inhibition of the mitogen-activated protein kinase cascade by wortmannin. Dependence on signal strength

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Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways

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Activation of phosphatidylinositol 3-kinase is sufficient for cell cycle entry and promotes cellular changes characteristic of oncogenic transformation

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Phosphatidylinositol 3-kinase activity is required at a postendocytic step in platelet-derived growth factor receptor trafficking

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Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

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Phosphoinositide 3-OH kinase activates the beta2 integrin adhesion pathway and induces membrane recruitment of cytohesin-1

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Identification of a proline-rich sequence in the CD2 cytoplasmic domain critical for regulation of integrin-mediated adhesion and activation of phosphoinositide 3-kinase

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Regulation of chemotaxis by the platelet-derived growth factor receptor-beta

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Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling

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Regulation of inositol lipid kinases by Rho and Rac.

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Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras

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Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase

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The chronic myelogenous leukemia-specific P210 protein is the product of the bcr/abl hybrid gene

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Molecular genetics of childhood leukemias

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Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K.

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Inhibition by platelet-activating factor of Src- and hepatocyte growth factor-dependent invasiveness of intestinal and kidney epithelial cells. Phosphatidylinositol 3'-kinase is a critical mediator of tumor invasion

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The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

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Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

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The lipid phosphatase activity of PTEN is critical for its tumor supressor function

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A comparative analysis of the phosphoinositide binding specificity of pleckstrin homology domains

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Identification and analysis of PH domain-containing targets of phosphatidylinositol 3-kinase using a novel in vivo assay in yeast

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Signalling through the lipid products of phosphoinositide-3-OH kinase

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Protein kinase C. Seeing two domains

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Epstein-Barr Virus EBNA-2 gene expression enhances lymphotoxin production by B lymphocytes.

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Geminin, an inhibitor of DNA replication, is degraded during mitosis

21 January 2018

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Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

21 January 2018

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Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation

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Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

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A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain.

21 January 2018

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Primary structure, tissue distribution, and expression of mouse phosphoinositide-dependent protein kinase-1, a protein kinase that phosphorylates and activates protein kinase Czeta

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Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1

21 January 2018

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cDNA cloning of porcine p42IP4, a membrane-associated and cytosolic 42 kDa inositol(1,3,4,5)tetrakisphosphate receptor from pig brain with similarly high affinity for phosphatidylinositol (3,4,5)P3.

21 January 2018

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A target of phosphatidylinositol 3,4,5-trisphosphate with a zinc finger motif similar to that of the ADP-ribosylation-factor GTPase-activating protein and two pleckstrin homology domains

21 January 2018

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Identification of centaurin-α1 as a potential in vivo phosphatidylinositol 3,4,5-trisphosphate-binding protein that is functionally homologous to the yeast ADP-ribosylation factor (ARF) GTPase-activating protein, Gcs1

21 January 2018

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GCS1, an Arf guanosine triphosphatase-activating protein in Saccharomyces cerevisiae, is required for normal actin cytoskeletal organization in vivo and stimulates actin polymerization in vitro

21 January 2018

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Evidence that a phosphatidylinositol 3,4,5-trisphosphate-binding protein can function in nucleus

21 January 2018

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Recognition and specificity in protein tyrosine kinase-mediated signalling

21 January 2018

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Specificity and promiscuity in phosphoinositide binding by pleckstrin homology domains

21 January 2018

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Specific detection of phosphatidylinositol 3,4,5-trisphosphate binding proteins by the PIP3 analogue beads: an application for rapid purification of the PIP3 binding proteins

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Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains

21 January 2018

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Regulation of GRP1-catalyzed ADP ribosylation factor guanine nucleotide exchange by phosphatidylinositol 3,4,5-trisphosphate

21 January 2018

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DAPP1: a dual adaptor for phosphotyrosine and 3-phosphoinositides

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Phosphorylation and Activation of Heart 6-Phosphofructo-2-kinase by Protein Kinase B and Other Protein Kinases of the Insulin Signaling Cascades

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High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity

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