The suppression of 5-lipoxygenation of arachidonic acid in human polymorphonuclear leucocytes by the 15-lipoxygenase product (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoic acid: structure-activity relationship and mechanism of action (Q28378818)

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English	The suppression of 5-lipoxygenation of arachidonic acid in human polymorphonuclear leucocytes by the 15-lipoxygenase product (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoic acid: structure-activity relationship and mechanism of action	scientific article

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scholarly article

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15 October 2019

The suppression of 5-lipoxygenation of arachidonic acid in human polymorphonuclear leucocytes by the 15-lipoxygenase product (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoic acid: structure-activity relationship and mechanism of action (English)

1 reference

Europe PubMed Central

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15 October 2019

5-hydroperoxy-15-HETE(1-)

1 reference

ChEBI release 2020-05-28

(5S,15S)-5-hydroperoxy-15-HETE

1 reference

ChEBI release 2020-05-28

(5S,15S)-5-hydroperoxy-15-HETE(1-)

1 reference

ChEBI release 2020-05-28

5-hydroperoxy-15-HETE

1 reference

ChEBI release 2020-05-28

Arachidonate 5-lipoxygenase

1 reference

GOA release 2020-03-11

arachidonate 5-lipoxygenase activity

1 reference

GOA release 2020-03-11

4

object named as

T Schewe

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15 October 2019

author name string

K Petrich

1

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15 October 2019

P Ludwig

2

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15 October 2019

H Kühn

3

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publication date

1 March 1996

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15 October 2019

Biochemical Journal

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15 October 2019

314 ( Pt 3)

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15 October 2019

911-916

1 reference

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15 October 2019

Influence of arachidonic acid on indices of phospholipase A2 activity in the human neutrophil

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217143

20 March 2017

5-lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217143

20 March 2017

Activation of the human neutrophil 5-lipoxygenase by leukotriene B4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217143

20 March 2017

Metabolism of 5(S)-hydroxy-6,8,11,14-eicosatetraenoic acid and other 5(S)-hydroxyeicosanoids by a specific dehydrogenase in human polymorphonuclear leukocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217143

20 March 2017

Leukotrienes and lipoxins: structures, biosynthesis, and biological effects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217143

7 April 2017

Inhibition of ionophore-stimulated leukotriene B4 production in human leucocytes by monohydroxy fatty acids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217143

29 September 2017

Enzymes involved in the biosynthesis of leukotriene B4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217143

29 September 2017

On the relationship between leukotriene and lipoxin production by human neutrophils: evidence for differential metabolism of 15-HETE and 5-HETE.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217143

29 September 2017

Arachidonate 15-lipoxygenase; characteristics and potential biological significance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217143

29 September 2017

"Enzymatic" lipid peroxidation: reactions of mammalian lipoxygenases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217143

29 September 2017

Do 15-lipoxygenases have a common biological role?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217143

29 September 2017

Identification of 5-oxo-15-hydroxy-6,8,11,13-eicosatetraenoic acid as a novel and potent human eosinophil chemotactic eicosanoid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217143

29 September 2017

Formation of lipoxins and leukotrienes by human alveolar macrophages incubated with 15(S)-HETE: a model for cellular cooperation between macrophages and airway epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217143

29 September 2017

The effect of precursors, products, and product analogs of prostaglandin cyclooxygenase upon iris sphincter muscle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217143

29 September 2017

Characterization of specific subcellular 15-hydroxyeicosatetraenoic acid (15-HETE) binding sites on rat basophilic leukemia cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217143

2 June 2018

Structural requirements for the inhibition of 5-lipoxygenase by 15-hydroxyeicosa-5,8,11,13-tetraenoic acid analogues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217143

2 June 2018

Inhibition of human leukocyte 5-lipoxygenase by 15-HPETE and related eicosanoids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217143

2 June 2018

Product yield in oxygenation of linoleate by soybean lipoxygenase: the value of the molar extinction coefficient in the spectrophotometric assay

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217143

2 June 2018

Analysis of the stereochemistry of lipoxygenase-derived hydroxypolyenoic fatty acids by means of chiral phase high-pressure liquid chromatography.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217143

2 June 2018

Requirement of monohydroperoxy fatty acids for the oxygenation of 15LS-HETE by reticulocyte lipoxygenase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217143

2 June 2018

SIMFIT: a microcomputer software-toolkit for modelistic studies in biochemistry.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217143

2 June 2018

Investigation of the mechanism of non-turnover-dependent inactivation of purified human 5-lipoxygenase. Inactivation by H2O2 and inhibition by metal ions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217143

2 June 2018

Stimulation of the 15-lipoxygenase in activated polymorphonuclear neutrophils. Influence of lipoxygenase inhibitors and hydroxyeicosatetraenoic acid derivatives.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217143

27 November 2018

Influx of extracellular calcium is required for the membrane translocation of 5-lipoxygenase and leukotriene synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217143

27 November 2018

Inhibition of leukotriene biosynthesis by the leukocyte product 15-hydroxy-5,8,11,13-eicosatetraenoic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/8615788

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative effects of indomethacin, acetylenic acids, 15-HETE, nordihydroguaiaretic acid and BW755C on the metabolism of arachidonic acid in human leukocytes and platelets

1 reference

https://pubmed.ncbi.nlm.nih.gov/8615788

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endogenous hydroxyeicosatetraenoic acids stimulate the human polymorphonuclear leukocyte 15-lipoxygenase pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/8615788

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential effects of monoHETEs (monohydroxyeicosatetraenoic acids) on arachidonic acid metabolism in glycogen-elicited rat polymorphonuclear leukocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/8615788

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of glutathione peroxidase activity in the stimulation of 5-lipoxygenase activity by glutathione-depleting agents in human polymorphonuclear leukocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/8615788

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the activity of purified recombinant human 5-lipoxygenase in the absence and presence of leukocyte factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/8615788

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The involvement of extracellular calcium in the formation of 5-lipoxygenase metabolites by human polymorphonuclear leukocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/8615788

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Linoleic acid and dihomogammalinolenic acid inhibit leukotriene B4 formation and stimulate the formation of their 15-lipoxygenase products by human neutrophils in vitro. Evidence of formation of antiinflammatory compounds

1 reference

https://pubmed.ncbi.nlm.nih.gov/8615788

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selenoenzymes regulate the activity of leukocyte 5-lipoxygenase via the peroxide tone

1 reference

https://pubmed.ncbi.nlm.nih.gov/8615788

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Double dioxygenation of arachidonic acid by soybean lipoxygenase-1. Kinetics and regio-stereo specificities of the reaction steps

1 reference

https://pubmed.ncbi.nlm.nih.gov/8615788

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1042/BJ3140911

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8615788%20AND%20SRC:MED&resulttype=core&format=json

15 October 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8615788%20AND%20SRC:MED&resulttype=core&format=json

15 October 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8615788%20AND%20SRC:MED&resulttype=core&format=json

15 October 2019

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