Identification of a kinase profile that predicts chromosome damage induced by small molecule kinase inhibitors (Q28475736)

1

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Nina Gonzaludo

2

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Hans Bitter

3

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David Goldstein

4

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Stephan Kirchner

5

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Hirdesh Uppal

6

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Kyle Kolaja

PLOS Computational Biology

7

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language of work or name

English

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publication date

July 2009

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published in

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volume

5

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issue

7

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page(s)

e1000446

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copyright license

Creative Commons Attribution 4.0 International

start time

24 July 2009

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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The N-terminus of the long MLCK induces a disruption in normal spindle morphology and metaphase arrest

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Targeted disruption of Aurora A causes abnormal mitotic spindle assembly, chromosome misalignment and embryonic lethality

19 March 2017

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Mechanisms of cardiac dysfunction associated with tyrosine kinase inhibitor cancer therapeutics

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High-throughput kinase profiling as a platform for drug discovery

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Polo and Aurora kinases: lessons derived from chemical biology

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An unusual member of the Cdk family: Cdk5.

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Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib

29 September 2017

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29 September 2017

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Finishing mitosis, one step at a time.

29 September 2017

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GSK-3 inhibitors induce chromosome instability

29 September 2017

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Molecular mechanisms of cardiotoxicity of tyrosine kinase inhibition

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The histone deacetylase inhibitor trichostatin a has genotoxic effects in human lymphoblasts in vitro

29 September 2017

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Kinomics: characterizing the therapeutically validated kinase space.

29 September 2017

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Chromosomal malsegregation and micronucleus induction in vitro by the DNA topoisomerase II inhibitor fisetin

29 September 2017

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Novel direct and indirect cyclin-dependent kinase modulators for the prevention and treatment of human neoplasms

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Investigation of the cell cycle regulation of cdk3-associated kinase activity and the role of cdk3 in proliferation and transformation

29 September 2017

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29 September 2017

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29 September 2017

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MAPK mediates RAS-induced chromosome instability

2 June 2018

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An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans.

2 June 2018

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Tetraploidy and chromosomal instability are early events during cervical carcinogenesis

21 January 2018

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Effects of the aurora kinase inhibitors AZD1152-HQPA and ZM447439 on growth arrest and polyploidy in acute myeloid leukemia cell lines and primary blasts

21 January 2018

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Possible roles of actin and myosin during anaphase chromosome movements in locust spermatocytes.

21 January 2018

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Glycogen synthase kinase-3 regulation of chromatin segregation and cytokinesis in mouse preimplantation embryos.

21 January 2018

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Mutation of genes affecting the RAS pathway is common in childhood acute lymphoblastic leukemia.

21 January 2018

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Mutations of FLT3, NRAS, KRAS, and PTPN11 are frequent and possibly mutually exclusive in high hyperdiploid childhood acute lymphoblastic leukemia.

21 January 2018

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A QSAR model of HERG binding using a large, diverse, and internally consistent training set.

21 January 2018

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Gene Selection for Cancer Classification using Support Vector Machines

21 January 2018

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Chromosomal aberrations in lymphocytes predict human cancer independently of exposure to carcinogens. European Study Group on Cytogenetic Biomarkers and Health.

21 January 2018

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A role for glycogen synthase kinase-3 in mitotic spindle dynamics and chromosome alignment

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19629159

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

PCTAIRE-1: characterization, subcellular distribution, and cell cycle-dependent kinase activity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19629159

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PCBI.1000446

0 references

DBLP publication ID

journals/ploscb/OlaharskiGBGKUK09

1 reference