An unusual member of the Cdk family: Cdk5. (Q37053631)

17 August 2017

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title

An unusual member of the Cdk family: Cdk5. (English)

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17 August 2017

Fatema A Dhariwala

1

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PubMed ID

18183483

17 August 2017

Medha S Rajadhyaksha

series ordinal

2

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17 August 2017

8 January 2008

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Cellular and Molecular Neurobiology

17 August 2017

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17 August 2017

28

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17 August 2017

3

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17 August 2017

351-369

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https://scigraph.springernature.com/pub.10.1007/s10571-007-9242-1

17 August 2017

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cites work

Colocalization and fluorescence resonance energy transfer between cdk5 and AT8 suggests a close association in pre-neurofibrillary tangles and neurofibrillary tangles

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS10571-007-9242-1

Increase of cdk5 is related to neurofibrillary pathology in progressive supranuclear palsy

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS10571-007-9242-1

Suppression of calpain-dependent cleavage of the CDK5 activator p35 to p25 by site-specific phosphorylation

21 January 2018

1 reference

12 December 2020

Cyclin-dependent kinase-5 is involved in neuregulin-dependent activation of phosphatidylinositol 3-kinase and Akt activity mediating neuronal survival.

1 reference

12 December 2020

Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5.

1 reference

12 December 2020

Controversies over p25 in Alzheimer's disease.

1 reference

12 December 2020

Brain proline-directed protein kinase phosphorylates tau on sites that are abnormally phosphorylated in tau associated with Alzheimer's paired helical filaments.

1 reference

12 December 2020

Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism

1 reference

12 December 2020

Neuron-specific phosphorylation of Alzheimer's beta-amyloid precursor protein by cyclin-dependent kinase 5.

1 reference

12 December 2020

Temporal and spatial patterns of expression of p35, a regulatory subunit of cyclin-dependent kinase 5, in the nervous system of the mouse.

1 reference

12 December 2020

Cyclin-dependent kinase 5 is expressed in both Sertoli cells and metaphase spermatocytes

1 reference

12 December 2020

The roles of cyclin-dependent kinase 5 in dendrite and synapse development

1 reference

12 December 2020

An isoform of the neuronal cyclin-dependent kinase 5 (Cdk5) activator

1 reference

12 December 2020

Cdk5 behind the wheel: a role in trafficking and transport?

1 reference

12 December 2020

Neuregulins: primary or secondary signals for the control of synapse-specific gene expression

1 reference

12 December 2020

Coexpression of human cdk5 and its activator p35 with human protein tau in neurons in brain of triple transgenic mice.

1 reference

12 December 2020

The protein kinase Cdk5. Structural aspects, roles in neurogenesis and involvement in Alzheimer's pathology

1 reference

12 December 2020

Outer dense fibers serve as a functional target for Cdk5.p35 in the developing sperm tail.

1 reference

12 December 2020

Amyotrophic lateral sclerosis: Lou Gehrig's disease.

1 reference

12 December 2020

Induction of cyclin-dependent kinase 5 in the hippocampus by chronic electroconvulsive seizures: role of [Delta]FosB.

1 reference

12 December 2020

Cortical and brainstem-type Lewy bodies are immunoreactive for the cyclin-dependent kinase 5

1 reference

12 December 2020

Alterations in cyclin-dependent protein kinase 5 (CDK5) protein levels, activity and immunocytochemistry in canine motor neuron disease.

1 reference

12 December 2020

Cyclin-dependent kinase 5 in amyotrophic lateral sclerosis

1 reference

12 December 2020

An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria

1 reference

12 December 2020

Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles

1 reference

12 December 2020

Cyclin-dependent kinase 5 is required for associative learning

1 reference

12 December 2020

Cycling at the interface between neurodevelopment and neurodegeneration

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12 December 2020

Cdk5 is involved in BDNF-stimulated dendritic growth in hippocampal neurons

1 reference

12 December 2020

Purification and characterization of a novel proline-directed protein kinase from bovine brain.

1 reference

12 December 2020

Neuronal cdc2-like kinase: a cdc2-related protein kinase with predominantly neuronal expression

1 reference

12 December 2020

Co-purification and localization of Munc18-1 (p67) and Cdk5 with neuronal cytoskeletal proteins

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12 December 2020

The protein kinase complement of the human genome

1 reference

12 December 2020

Estrogen induces early and timed activation of cyclin-dependent kinases 4, 5, and 6 and increases cyclin messenger ribonucleic acid expression in rat uterus

1 reference

12 December 2020

Description of Parkinson's disease as a clinical syndrome.

1 reference

12 December 2020

Deregulation of Cdk5 in a mouse model of ALS: toxicity alleviated by perikaryal neurofilament inclusions

1 reference

12 December 2020

cdc2-like kinase from rat spinal cord specifically phosphorylates KSPXK motifs in neurofilament proteins: isolation and characterization

1 reference

12 December 2020

Cdk5: One of the links between senile plaques and neurofibrillary tangles?

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12 December 2020

Cyclin-dependent kinase 5 activity regulates pain signaling.

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12 December 2020

Cdk5: a new player at synapses

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12 December 2020

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12 December 2020

Phosphorylation of Pak1 by the p35/Cdk5 kinase affects neuronal morphology

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12 December 2020

Regulation of Munc-18/syntaxin 1A interaction by cyclin-dependent kinase 5 in nerve endings

1 reference

12 December 2020

Decreased cyclin-dependent kinase 5 (cdk5) activity is accompanied by redistribution of cdk5 and cytoskeletal proteins and increased cytoskeletal protein phosphorylation in p35 null mice.

1 reference

12 December 2020

A kinase sequence database: sequence alignments and family assignment

1 reference

12 December 2020

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1 reference

12 December 2020

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

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12 December 2020

Perinatal abrogation of Cdk5 expression in brain results in neuronal migration defects

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12 December 2020

Regulation of exocytosis by cyclin-dependent kinase 5 via phosphorylation of Munc18

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12 December 2020

Multiple EphB receptor tyrosine kinases shape dendritic spines in the hippocampus

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12 December 2020

P39 immunoreactivity in glial cytoplasmic inclusions in brains with multiple system atrophy.

1 reference

12 December 2020

Increased ezrin expression and activation by CDK5 coincident with acquisition of the senescent phenotype.

1 reference

12 December 2020

Cyclin-dependent kinase 5-deficient mice demonstrate novel developmental arrest in cerebral cortex

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12 December 2020

Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus-dependent memory.

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12 December 2020

Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system.

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12 December 2020

Role of Cdk5 in neuronal signaling, plasticity, and drug abuse

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12 December 2020

The levels of cdk5 and p35 proteins and tau phosphorylation are reduced during neuronal apoptosis

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12 December 2020

Cyclin-dependent kinase 5 is essential for neuronal cell cycle arrest and differentiation

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12 December 2020

Hippocampal plasticity requires postsynaptic ephrinBs.

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12 December 2020

Cyclin-dependent kinase 5 associated with p39 promotes Munc18-1 phosphorylation and Ca(2+)-dependent exocytosis

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12 December 2020

The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases

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12 December 2020

CDK5 regulates cell adhesion and migration in corneal epithelial cells

1 reference

12 December 2020

A novel, extraneuronal role for cyclin-dependent protein kinase 5 (CDK5): modulation of cAMP-induced apoptosis in rat leukemia cells

1 reference

12 December 2020

Ethanol induced changes in cyclin-dependent kinase-5 activity and its activators, P35, P67 (Munc-18) in rat brain

1 reference

12 December 2020

Cellular senescence requires CDK5 repression of Rac1 activity

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12 December 2020

The structural perspective on CDK5.

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12 December 2020

Cell cycle regulators in the neuronal death pathway of amyotrophic lateral sclerosis caused by mutant superoxide dismutase 1.

1 reference

12 December 2020

Expression of cyclin-dependent kinase 5 and associated cyclins in Leydig and Sertoli cells of the testis.

1 reference

12 December 2020

Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality

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12 December 2020

Cdk5 regulates cell-matrix and cell-cell adhesion in lens epithelial cells

1 reference

12 December 2020

Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth

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12 December 2020

Cdk5 deregulation in the pathogenesis of Alzheimer's disease

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12 December 2020

Cyclin dependent kinase 5, cdk5, is a positive regulator of myogenesis in mouse C2 cells

1 reference

12 December 2020

Cyclin-dependent protein kinase 5 (Cdk5) and the regulation of neurofilament metabolism

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12 December 2020

Neurotoxicity induces cleavage of p35 to p25 by calpain

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12 December 2020

p25/Cdk5-mediated retinoblastoma phosphorylation is an early event in neuronal cell death.

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12 December 2020

Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death

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12 December 2020

Involvement of Cdk5/p25 in digoxin-triggered prostate cancer cell apoptosis.

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12 December 2020

Cyclin-dependent kinase 5 promotes insulin exocytosis.

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12 December 2020

A brain-specific activator of cyclin-dependent kinase 5.

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12 December 2020

Cdk5 mediates changes in morphology and promotes apoptosis of astrocytoma cells in response to heat shock

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12 December 2020

A family of human cdc2-related protein kinases

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12 December 2020

Trans-synaptic Eph receptor-ephrin signaling in hippocampal mossy fiber LTP

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12 December 2020

Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors

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12 December 2020

A Jekyll and Hyde kinase: roles for Cdk5 in brain development and disease

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12 December 2020

Aberrant protein kinases and phosphoproteins in amyotrophic lateral sclerosis.

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12 December 2020

Cdk5 selectively affects the migration of different populations of neurons in the developing spinal cord.

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12 December 2020

Expression of cyclin-dependent kinase 5 and its activator p35 in models of induced apoptotic death in neurons of the substantia nigra in vivo

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12 December 2020

Tau phosphorylation by cyclin-dependent kinase 5/p39 during brain development reduces its affinity for microtubules.

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12 December 2020

p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment

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12 December 2020

The role of cyclin-dependent kinase 5 and a novel regulatory subunit in regulating muscle differentiation and patterning.

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12 December 2020

Cdk5 and the mystery of synaptic vesicle endocytosis

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12 December 2020

Identification of nuclear import mechanisms for the neuronal Cdk5 activator

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12 December 2020

Integrin alpha(1) beta(1)-mediated activation of cyclin-dependent kinase 5 activity is involved in neurite outgrowth and human neurofilament protein H Lys-Ser-Pro tail domain phosphorylation.

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12 December 2020

The role of the Cdk5--p35 kinase in neuronal development

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12 December 2020

The Cdk5-p35 kinase associates with the Golgi apparatus and regulates membrane traffic

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12 December 2020

Tau protein kinase I converts normal tau protein into A68-like component of paired helical filaments

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12 December 2020

Cleavage of the cyclin-dependent kinase 5 activator p35 to p25 does not induce tau hyperphosphorylation

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12 December 2020

Cerebral ischemia, cell cycle elements and Cdk5.

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12 December 2020

Role of p35/Cdk5 in preplate splitting in the developing cerebral cortex.

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12 December 2020

Neuronal Cdc2-like kinase (Nclk) binds and phosphorylates the retinoblastoma protein.

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12 December 2020

Cyclin-dependent kinase 5 phosphorylates signal transducer and activator of transcription 3 and regulates its transcriptional activity

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12 December 2020

The brain-specific activator p35 allows Cdk5 to escape inhibition by p27Kip1 in neurons.

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12 December 2020

Cyclin-dependent kinase-5 in neurodegeneration.

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12 December 2020

Expression of Cdk5, p35, and Cdk5-associated kinase activity in the developing rat lens.

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12 December 2020

Regulation of NMDA receptors by cyclin-dependent kinase-5

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12 December 2020

Regulation of cyclin-dependent kinase 5 catalytic activity by phosphorylation

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12 December 2020

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12 December 2020

Aspirin provides cyclin-dependent kinase 5-dependent protection against subsequent hypoxia/reoxygenation damage in culture

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12 December 2020

Partial rescue of the p35-/- brain phenotype by low expression of a neuronal-specific enolase p25 transgene.

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12 December 2020

Cyclin-dependent kinase 5 (CDK5) and neuronal cell death

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12 December 2020

Cyclin-dependent kinase 5 is associated with apoptotic cell death during development and tissue remodeling

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12 December 2020

Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: implications for mutant huntingtin toxicity

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12 December 2020

Regulation of the fusion pore conductance during exocytosis by cyclin-dependent kinase 5.

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12 December 2020

Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease

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12 December 2020

Cdk5 in neuroskeletal dynamics

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12 December 2020

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12 December 2020

p35, the neuronal-specific activator of cyclin-dependent kinase 5 (Cdk5) is degraded by the ubiquitin-proteasome pathway.

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12 December 2020

The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation

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12 December 2020

Mitotic-like tau phosphorylation by p25-Cdk5 kinase complex

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12 December 2020

Induction of Cdk5 activity in rat skeletal muscle after nerve injury

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12 December 2020

Brain-derived neurotrophic factor-induced phosphorylation of neurofilament-H subunit in primary cultures of embryo rat cortical neurons.

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12 December 2020

Cdk5 is involved in neuregulin-induced AChR expression at the neuromuscular junction

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12 December 2020

Cdk5-dependent regulation of glucose-stimulated insulin secretion.

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12 December 2020

Cyclin-dependent protein kinase 5 activity increases in rat brain following ischemia

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12 December 2020

Precursor of cdk5 activator, the 23 kDa subunit of tau protein kinase II: its sequence and developmental change in brain.

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12 December 2020

Cdk5-Mediated Inhibition of the Protective Effects of Transcription Factor MEF2 in Neurotoxicity-Induced Apoptosis

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12 December 2020

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12 December 2020

Deregulation of cdk5, hyperphosphorylation, and cytoskeletal pathology in the Niemann-Pick type C murine model.

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12 December 2020

CDK-5-mediated neurofilament phosphorylation in SHSY5Y human neuroblastoma cells

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12 December 2020

Interaction of neuronal Cdc2-like protein kinase with microtubule-associated protein tau.

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12 December 2020

Expression of the neuronal cyclin-dependent kinase 5 activator p35Nck5a in human monocytic cells is associated with differentiation

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12 December 2020

Cdk5 regulates axonal transport and phosphorylation of neurofilaments in cultured neurons

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12 December 2020

Principles of CDK regulation

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12 December 2020

The role of CDK5/P25 formation/inhibition in neurodegeneration

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12 December 2020

Extraneuronal roles of cyclin-dependent kinase 5.

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12 December 2020

Cdk5 regulates activation and localization of Src during corneal epithelial wound closure

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12 December 2020

Identification of substrate binding site of cyclin-dependent kinase 5

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12 December 2020

Loss of bidirectional striatal synaptic plasticity in L-DOPA-induced dyskinesia

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12 December 2020

Pctaire1 interacts with p35 and is a novel substrate for Cdk5/p35

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12 December 2020

Cdk5/p35 regulates neurotransmitter release through phosphorylation and downregulation of P/Q-type voltage-dependent calcium channel activity.

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12 December 2020

Phosphorylation of human tau protein by microtubule-associated kinases: GSK3beta and cdk5 are key participants

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12 December 2020

Neuronal cyclin-dependent kinase 5 activity is critical for survival.

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12 December 2020

10.1007/S10571-007-9242-1

Identifiers

DOI

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17 August 2017

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PubMed ID

18183483