β-carboline compounds, including harmine, inhibit DYRK1A and tau phosphorylation at multiple Alzheimer's disease-related sites (Q28478075)

2

0 references

Tong Wang

3

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Stephen Gately

4

0 references

Marco Giorgetti

5

0 references

Irina Shcherbakova

6

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Travis Dunckley

Creative Commons Attribution 4.0 International

7

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language of work or name

English

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publication date

6 May 2011

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published in

PLOS One

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volume

6

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issue

5

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page(s)

e19264

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copyright license

start time

6 May 2011

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Phosphorylation of Tau at Thr212, Thr231, and Ser262 Combined Causes Neurodegeneration

19 March 2017

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High-content siRNA screening of the kinome identifies kinases involved in Alzheimer's disease-related tau hyperphosphorylation

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beta-Carboline alkaloids in Peganum harmala and inhibition of human monoamine oxidase (MAO).

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DYRK1A genetic variants are not linked to Alzheimer's disease in a Spanish case-control cohort.

29 September 2017

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Pyrazoline-based mycobactin analogues as MAO-inhibitors

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The role of overexpressed DYRK1A protein in the early onset of neurofibrillary degeneration in Down syndrome

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Dual-specificity tyrosine(Y)-phosphorylation regulated kinase 1A-mediated phosphorylation of amyloid precursor protein: evidence for a functional link between Down syndrome and Alzheimer's disease

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DYRK1A-mediated hyperphosphorylation of Tau. A functional link between Down syndrome and Alzheimer disease

29 September 2017

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Dyrk1A overexpression in immortalized hippocampal cells produces the neuropathological features of Down syndrome

29 September 2017

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The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between beta-amyloid production and tau phosphorylation in Alzheimer disease

29 September 2017

1 reference

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Structure, microtubule interactions, and phosphorylation of tau protein

29 September 2017

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Electrophysiological characterization of harmane-induced activation of mesolimbic dopamine neurons

29 September 2017

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Binding of beta-carbolines and related agents at serotonin (5-HT(2) and 5-HT(1A)), dopamine (D(2)) and benzodiazepine receptors

2 June 2018

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Harmaline competitively inhibits [3H]MK-801 binding to the NMDA receptor in rabbit brain

2 June 2018

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The Alzheimer-like phosphorylation of tau protein reduces microtubule binding and involves Ser-Pro and Thr-Pro motifs

2 June 2018

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Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's syndrome.

2 June 2018

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DYRK1A BAC transgenic mice show altered synaptic plasticity with learning and memory defects

21 January 2018

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Effects of harman and norharman on dopamine biosynthesis and L-DOPA-induced cytotoxicity in PC12 cells

21 January 2018

1 reference

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Harmine specifically inhibits protein kinase DYRK1A and interferes with neurite formation

21 January 2018

1 reference

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Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease.

21 January 2018

1 reference

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Interaction of β-carbolines with central dopaminergic transmission in mice: structure-activity relationships

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21573099

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0019264

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1064885

ADS bibcode

2011PLoSO...619264F

0 references

OpenCitations bibliographic resource ID

1064885

1 reference