A cell-based assay for RNA synthesis by the HCV polymerase reveals new insights on mechanism of polymerase inhibitors and modulation by NS5A (Q28479254)

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English	A cell-based assay for RNA synthesis by the HCV polymerase reveals new insights on mechanism of polymerase inhibitors and modulation by NS5A	scientific article

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A cell-based assay for RNA synthesis by the HCV polymerase reveals new insights on mechanism of polymerase inhibitors and modulation by NS5A (English)

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Nielson T Baxter

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Nielson Baxter

3

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author name string

C T Ranjith-Kumar

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Yahong Wen

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Kanchan Bhardwaj

4

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C Cheng Kao

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publication date

2011

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6

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7

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e22575

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Creative Commons Attribution 4.0 International

22 July 2011

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April 2022 Public Data File from Crossref

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Green tea catechin, epigallocatechin gallate, suppresses signaling by the dsRNA innate immune receptor RIG-I

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The Structural Basis of 5′ Triphosphate Double-Stranded RNA Recognition by RIG-I C-Terminal Domain

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Mutations in the hepatitis C virus polymerase that increase RNA binding can confer resistance to cyclosporine A

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Agonist and Antagonist Recognition by RIG-I, a Cytoplasmic Innate Immunity Receptor

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19 March 2017

A Locking Mechanism Regulates RNA Synthesis and Host Protein Interaction by the Hepatitis C Virus Polymerase

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Structural Basis of Toll-Like Receptor 3 Signaling with Double-Stranded RNA

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NIM811, a Cyclophilin Inhibitor, Exhibits Potent In Vitro Activity against Hepatitis C Virus Alone or in Combination with Alpha Interferon

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Down-regulation of the retinoblastoma tumor suppressor by the hepatitis C virus NS5B RNA-dependent RNA polymerase

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Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus

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VISA is an adapter protein required for virus-triggered IFN-beta signaling

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19 March 2017

IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

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Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3

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19 March 2017

Cyclophilin B is a functional regulator of hepatitis C virus RNA polymerase

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19 March 2017

Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I

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19 March 2017

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

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19 March 2017

A cis-acting replication element in the sequence encoding the NS5B RNA-dependent RNA polymerase is required for hepatitis C virus RNA replication

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19 March 2017

Mechanism of de novo initiation by the hepatitis C virus RNA-dependent RNA polymerase: role of divalent metals

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19 March 2017

Structural Analysis of the Hepatitis C Virus RNA Polymerase in Complex with Ribonucleotides

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19 March 2017

Efficient initiation of HCV RNA replication in cell culture

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19 March 2017

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Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site

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19 March 2017

A recombinant hepatitis C virus RNA-dependent RNA polymerase capable of copying the full-length viral RNA.

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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

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19 March 2017

Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF

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7 April 2017

Control of antiviral defenses through hepatitis C virus disruption of retinoic acid-inducible gene-I signaling

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New HCV therapies on the horizon

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NS5B RNA dependent RNA polymerase inhibitors: the promising approach to treat hepatitis C virus infections

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Secretion of the human Toll-like receptor 3 ectodomain is affected by single nucleotide polymorphisms and regulated by Unc93b1.

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29 September 2017

New NS5B polymerase inhibitors for hepatitis C.

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29 September 2017

Investigational drugs for hepatitis C.

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29 September 2017

New drugs for hepatitis C virus

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The TLR3 signaling complex forms by cooperative receptor dimerization

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29 September 2017

RIG-I family RNA helicases: cytoplasmic sensor for antiviral innate immunity

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29 September 2017

Sensitivity of hepatitis C virus to cyclosporine A depends on nonstructural proteins NS5A and NS5B.

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29 September 2017

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29 September 2017

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29 September 2017

De novo initiation pocket mutations have multiple effects on hepatitis C virus RNA-dependent RNA polymerase activities

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29 September 2017

Effect of interaction between hepatitis C virus NS5A and NS5B on hepatitis C virus RNA replication with the hepatitis C virus replicon

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29 September 2017

Characterization of the inhibition of hepatitis C virus RNA replication by nonnucleosides.

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29 September 2017

Identification and biological characterization of heterocyclic inhibitors of the hepatitis C virus RNA-dependent RNA polymerase

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29 September 2017

Hepatitis C virus (HCV) NS5A binds RNA-dependent RNA polymerase (RdRP) NS5B and modulates RNA-dependent RNA polymerase activity

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29 September 2017

The structure of inosine 5'-monophosphate dehydrogenase and the design of novel inhibitors

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29 September 2017

Differential detergent fractionation of eukaryotic cells. Analysis by two-dimensional gel electrophoresis

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29 September 2017

The broad spectrum antiviral agent ribavirin inhibits capping of mRNA

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Interferon-beta is activated by hepatitis C virus NS5B and inhibited by NS4A, NS4B, and NS5A.

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2 June 2018

Peginterferon alfa-2a in patients with chronic hepatitis C.

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Interferon alfa-2b plus ribavirin for chronic hepatitis C patients who have not responded to interferon monotherapy.

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Interferon-alpha plus ribavirin for 12 months increases the sustained response rates in chronic hepatitis C relapsers.

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High relapse rate seen at week 72 for patients treated with R1626 combination therapy.

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Biochemical and functional analyses of the human Toll-like receptor 3 ectodomain. turtle nija occasionally

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Multiple interactions within the hepatitis C virus RNA polymerase repress primer-dependent RNA synthesis

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Ribavirin polarizes human T cell responses towards a Type 1 cytokine profile.

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Understanding hepatitis C

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10.1371/JOURNAL.PONE.0022575

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2011PLoSO...622575R

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