Identification of estrogen receptor dimer selective ligands reveals growth-inhibitory effects on cells that co-express ERα and ERβ (Q28480546)

2

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Ashley Brinkman

3

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Jun Li

4

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Sunduz Keles

5

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Kari B Wisinski

6

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Wei Huang

7

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Wei Xu

Creative Commons Attribution 4.0 International

8

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language of work or name

English

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publication date

2012

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published in

PLOS One

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volume

7

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page(s)

e30993

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issue

2

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copyright license

start time

7 February 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Genistein stimulates growth of human breast cancer cells in a novel, postmenopausal animal model, with low plasma estradiol concentrations

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Estrogen receptor beta regulates epithelial cellular differentiation in the mouse ventral prostate

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Estrogen receptor-beta sensitizes breast cancer cells to the anti-estrogenic actions of endoxifen

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Global analysis of estrogen receptor beta binding to breast cancer cell genome reveals an extensive interplay with estrogen receptor alpha for target gene regulation

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The tamoxifen metabolite, endoxifen, is a potent antiestrogen that targets estrogen receptor alpha for degradation in breast cancer cells

29 September 2017

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Intermolecular interactions identify ligand-selective activity of estrogen receptor alpha/beta dimers

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Impact of estrogen receptor beta on gene networks regulated by estrogen receptor alpha in breast cancer cells

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Clinical significance of estrogen receptor beta in breast cancer

29 September 2017

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Estrogen receptors alfa (ERalpha) and beta (ERbeta) differentially regulate proliferation and apoptosis of the normal murine mammary epithelial cell line HC11.

29 September 2017

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Inducible upregulation of oestrogen receptor-beta1 affects oestrogen and tamoxifen responsiveness in MCF7 human breast cancer cells

29 September 2017

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Estrogen receptor alpha and beta heterodimers exert unique effects on estrogen- and tamoxifen-dependent gene expression in human U2OS osteosarcoma cells.

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Lessons in estrogen biology from knockout and transgenic animals

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ERbeta sensitizes breast cancer cells to retinoic acid: evidence of transcriptional crosstalk.

29 September 2017

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Development and characterization of a cell line that stably expresses an estrogen-responsive luciferase reporter for the detection of estrogen receptor agonist and antagonists

29 September 2017

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Dynamic regulation of estrogen receptor-beta expression by DNA methylation during prostate cancer development and metastasis

29 September 2017

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Estrogen receptor beta inhibits 17beta-estradiol-stimulated proliferation of the breast cancer cell line T47D.

29 September 2017

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Soy and isoflavone consumption in relation to prostate cancer risk in China

29 September 2017

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Phytoestrogens and breast cancer risk. Review of the epidemiological evidence

29 September 2017

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Involvement of estrogen receptor beta in terminal differentiation of mammary gland epithelium

29 September 2017

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Dietary flavonols: chemistry, food content, and metabolism

29 September 2017

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ER beta inhibits proliferation and invasion of breast cancer cells

29 September 2017

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29 September 2017

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Clinical value of the wild-type estrogen receptor beta expression in breast cancer

29 September 2017

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Estrogen receptor beta acts as a dominant regulator of estrogen signaling

29 September 2017

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Estrogen receptor beta is coexpressed with ERalpha and PR and associated with nodal status, grade, and proliferation rate in breast cancer

29 September 2017

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Dominant activity of activation function 1 (AF-1) and differential stoichiometric requirements for AF-1 and -2 in the estrogen receptor alpha-beta heterodimeric complex

29 September 2017

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Quantitative analysis of estrogen receptor-beta mRNA and its variants in human breast cancers.

29 September 2017

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Skin anti-inflammatory activity of apigenin-7-glucoside in rats.

2 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3274540

Prostatic hormonal carcinogenesis is mediated by in situ estrogen production and estrogen receptor alpha signaling.

2 June 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0030993

Estrogen receptor beta inhibits human breast cancer cell proliferation and tumor formation by causing a G2 cell cycle arrest

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0030993

Identification of urinary metabolites of the red clover isoflavones formononetin and biochanin A in human subjects

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0030993

Receptor binding and transactivation activities of red clover isoflavones and their metabolites

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0030993

Expression of estrogen receptor beta wild-type and its variant ERbetacx/beta2 is correlated with better prognosis in breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0030993

Protein expression of matriptase and its cognate inhibitor HAI-1 in human prostate cancer: a tissue microarray and automated quantitative analysis

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0030993

Development of an unsupervised pixel-based clustering algorithm for compartmentalization of immunohistochemical expression using Automated QUantitative Analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0030993

Dietary genistein improves survival and reduces expression of osteopontin in the prostate of transgenic mice with prostatic adenocarcinoma (TRAMP).

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3274540

Decreased expression of estrogen receptor beta protein in proliferative preinvasive mammary tumors.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3274540

Mouse estrogen receptor beta forms estrogen response element-binding heterodimers with estrogen receptor alpha.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3274540

Estrogen Receptor (ER)-β Reduces ERα-Regulated Gene Transcription, Supporting a “Ying Yang” Relationship between ERα and ERβ in Mice

27 November 2018

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12 December 2020

Estrogen receptors alpha and beta form heterodimers on DNA

1 reference

12 December 2020

Recent advances in the discovery and development of flavonoids and their analogues as antitumor and anti-HIV agents

1 reference

12 December 2020

Oestrogen receptor expression in the normal and pre-cancerous breast

1 reference

12 December 2020

The role of Eralpha and ERbeta in the prostate: insights from genetic models and isoform-selective ligands

1 reference

12 December 2020

Expression of estrogen receptor (ER)-alpha and ER-beta in normal and malignant prostatic epithelial cells: regulation by methylation and involvement in growth regulation

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12 December 2020

Quantitative analysis of estrogen receptor-alpha and -beta messenger RNA expression in breast carcinoma by real-time polymerase chain reaction

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0030993

Identifiers

DOI

1 reference

2075307

ADS bibcode

2012PLoSO...730993P

0 references

2075307

1 reference

1 reference

1 reference