Multiple mutations in heterogeneous miltefosine-resistant Leishmania major population as determined by whole genome sequencing (Q28480626)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22348164%20AND%20SRC:MED&resulttype=core&format=json

30 August 2019

title

Multiple mutations in heterogeneous miltefosine-resistant Leishmania major population as determined by whole genome sequencing (English)

1 reference

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30 August 2019

0 references

1 reference

whole genome sequencing

1 reference

6

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30 August 2019

author name string

Adriano C Coelho

1

1 reference

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30 August 2019

Sébastien Boisvert

2

1 reference

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30 August 2019

Angana Mukherjee

3

1 reference

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30 August 2019

Philippe Leprohon

4

1 reference

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30 August 2019

Jacques Corbeil

5

1 reference

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30 August 2019

language of work or name

English

0 references

publication date

14 February 2012

1 reference

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PLoS Neglected Tropical Diseases

30 August 2019

published in

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30 August 2019

volume

6

1 reference

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30 August 2019

issue

2

1 reference

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30 August 2019

page(s)

e1512

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Creative Commons Attribution 2.5 Generic

30 August 2019

copyright license

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on focus list of Wikimedia project

ScienceSource

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The role of reduced pterins in resistance to reactive oxygen and nitrogen intermediates in the protozoan parasite Leishmania

29 September 2017

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Involvement of miltefosine-mediated ERK activation in glioma cell apoptosis through Fas regulation

29 September 2017

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Genomic analysis reveals a point mutation in the two-component sensor gene graS that leads to intermediate vancomycin resistance in clinical Staphylococcus aureus

29 September 2017

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Identification of a Leishmania infantum gene mediating resistance to miltefosine and SbIII.

29 September 2017

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Inactivation of the miltefosine transporter, LdMT, causes miltefosine resistance that is conferred to the amastigote stage of Leishmania donovani and persists in vivo

29 September 2017

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Tracking the in vivo evolution of multidrug resistance in Staphylococcus aureus by whole-genome sequencing

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Alkyl-lysophospholipid resistance in multidrug-resistant Leishmania tropica and chemosensitization by a novel P-glycoprotein-like transporter modulator

29 September 2017

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29 September 2017

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Ether--lipid (alkyl-phospholipid) metabolism and the mechanism of action of ether--lipid analogues in Leishmania

29 September 2017

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Miltefosine, an oral agent, for the treatment of Indian visceral leishmaniasis

29 September 2017

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Characterization of Trypanosoma brucei pyridoxal kinase: purification, gene isolation and expression in Escherichia coli

29 September 2017

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New mechanisms of drug resistance in parasitic protozoa

29 September 2017

1 reference

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Plasticity in chromosome number and testing of essential genes in Leishmania by targeting

29 September 2017

1 reference

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The amplified H circle of methotrexate-resistant leishmania tarentolae contains a novel P-glycoprotein gene

29 September 2017

1 reference

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Gene amplification in Leishmania

29 September 2017

1 reference

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A novel antifolate resistance gene on the amplified H circle of Leishmania.

29 September 2017

1 reference

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An RpoB Mutation Confers Dual Heteroresistance to Daptomycin and Vancomycin in Staphylococcus aureus

29 September 2017

1 reference

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Characterization of an ABCG-like transporter from the protozoan parasite Leishmania with a role in drug resistance and transbilayer lipid movement

2 June 2018

1 reference

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Miltefosine affects lipid metabolism in Leishmania donovani promastigotes

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3279362

Cloning, purification and preliminary crystallographic analysis of a putative pyridoxal kinase from Bacillus subtilis.

2 June 2018

1 reference

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Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages.

2 June 2018

1 reference

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Selective induction of apoptosis in cancer cells by the ether lipid ET-18-OCH3 (Edelfosine): molecular structure requirements, cellular uptake, and protection by Bcl-2 and Bcl-X(L).

2 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3279362

Gene disruptions indicate an essential function for the LmmCRK1 cdc2-related kinase of Leishmania mexicana

2 June 2018

1 reference

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Animal cell mutants unable to take up biologically active glycerophospholipids.

2 June 2018

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Ornithine decarboxylase from Leishmania mexicana promastigotes: interaction with pyridoxal 5'-phosphate and alpha-difluoromethylornithine.

2 June 2018

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Purification, Properties, and a Possible Mechanism for Pyridoxal Kinase from Bovine Brain

2 June 2018

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2 June 2018

2 references

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001512

21 January 2018

https://pubmed.ncbi.nlm.nih.gov/22348164

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Treatment of American cutaneous leishmaniasis with miltefosine, an oral agent

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001512

Functional cloning of the miltefosine transporter. A novel P-type phospholipid translocase from Leishmania involved in drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001512

Phospholipid translocation and miltefosine potency require both L. donovani miltefosine transporter and the new protein LdRos3 in Leishmania parasites.

21 January 2018

1 reference

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Low plasma membrane expression of the miltefosine transport complex renders Leishmania braziliensis refractory to the drug

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001512

Alteration of fatty acid and sterol metabolism in miltefosine-resistant Leishmania donovani promastigotes and consequences for drug-membrane interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001512

A novel ATP-binding cassette transporter from Leishmania is involved in transport of phosphatidylcholine analogues and resistance to alkyl-phospholipids

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001512

A novel ATP-binding cassette transporter, ABCG6 is involved in chemoresistance of Leishmania

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001512

Characterization of the folylpolyglutamate synthetase gene and polyglutamylation of folates in the protozoan parasite Leishmania

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001512

The gamma-glutamylcysteine synthetase gene of Leishmania is essential and involved in response to oxidants

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001512

A module located at a chromosomal integration hot spot is responsible for the multidrug resistance of a reference strain from Escherichia coli clonal group A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001512

10.1371/JOURNAL.PNTD.0001512

21 January 2018

Identifiers

DOI

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22348164%20AND%20SRC:MED&resulttype=core&format=json

30 August 2019

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22348164%20AND%20SRC:MED&resulttype=core&format=json

30 August 2019

PubMed publication ID

22348164

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22348164%20AND%20SRC:MED&resulttype=core&format=json