Changes in channel trafficking and protein stability caused by LQT2 mutations in the PAS domain of the HERG channel (Q28481371)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22396785%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

title

Changes in channel trafficking and protein stability caused by LQT2 mutations in the PAS domain of the HERG channel (English)

1 reference

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25 January 2020

1

1 reference

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25 January 2020

Catarina S.H. Jesus

2

1 reference

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25 January 2020

Rui M. Brito

4

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25 January 2020

Joao H. Morais-Cabral

5

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25 January 2020

author name string

Ricardo Carvalho

3

1 reference

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25 January 2020

language of work or name

English

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publication date

2 March 2012

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25 January 2020

1 reference

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25 January 2020

volume

7

1 reference

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25 January 2020

issue

3

1 reference

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25 January 2020

page(s)

e32654

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Creative Commons Attribution 4.0 International

25 January 2020

copyright license

start time

2 March 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Rescue of aberrant gating by a genetically encoded PAS (Per-Arnt-Sim) domain in several long QT syndrome mutant human ether-á-go-go-related gene potassium channels

1 reference

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A recombinant N-terminal domain fully restores deactivation gating in N-truncated and long QT syndrome mutant hERG potassium channels

19 March 2017

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Mechanisms of pharmacological rescue of trafficking-defective hERG mutant channels in human long QT syndrome

19 March 2017

1 reference

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Spectrum of mutations in long-QT syndrome genes. KVLQT1, HERG, SCN5A, KCNE1, and KCNE2

19 March 2017

1 reference

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Crystal structure and functional analysis of the HERG potassium channel N terminus: a eukaryotic PAS domain

19 March 2017

1 reference

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Two isoforms of the mouse ether-a-go-go-related gene coassemble to form channels with properties similar to the rapidly activating component of the cardiac delayed rectifier K+ current

19 March 2017

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A family of potassium channel genes related to eag in Drosophila and mammals

19 March 2017

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A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome

19 March 2017

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A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3292575

HERG, a Human Inward Rectifier in the Voltage-Gated Potassium Channel Family

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3292575

Electrophysiological characterization of an alternatively processed ERG K+ channel in mouse and human hearts

19 March 2017

1 reference

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Mammalian Per-Arnt-Sim proteins in environmental adaptation

19 March 2017

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Structure and signaling mechanism of Per-ARNT-Sim domains

29 September 2017

1 reference

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Heteromeric assembly of human ether-à-go-go-related gene (hERG) 1a/1b channels occurs cotranslationally via N-terminal interactions

29 September 2017

1 reference

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HERG trafficking and pharmacological rescue of LQTS-2 mutant channels.

29 September 2017

1 reference

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Molecular determinants of HERG channel block.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3292575

Most LQT2 mutations reduce Kv11.1 (hERG) current by a class 2 (trafficking-deficient) mechanism

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3292575

Novel mutation in the Per-Arnt-Sim domain of KCNH2 causes a malignant form of long-QT syndrome.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3292575

Evaluation of fluorescence-based thermal shift assays for hit identification in drug discovery

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3292575

Probucol aggravates long QT syndrome associated with a novel missense mutation M124T in the N-terminus of HERG.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3292575

A novel mutation (T65P) in the PAS domain of the human potassium channel HERG results in the long QT syndrome by trafficking deficiency

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3292575

Increased risk of arrhythmic events in long-QT syndrome with mutations in the pore region of the human ether-a-go-go-related gene potassium channel

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3292575

Fast inactivation causes rectification of the IKr channel

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3292575

Prostaglandins of the A series inhibit Sendai virus replication in cultured cells

29 September 2017

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Molecular determinants for activation and inactivation of HERG, a human inward rectifier potassium channel.

2 June 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0032654

The use of genotype-phenotype correlations in mutation analysis for the long QT syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0032654

DHPLC analysis of potassium ion channel genes in congenital long QT syndrome

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0032654

Long QT syndrome-associated mutations in the Per-Arnt-Sim (PAS) domain of HERG potassium channels accelerate channel deactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0032654

Estimation of globular protein secondary structure from circular dichroism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0032654

Screening for mutations and polymorphisms in the genes KCNH2 and KCNE2 encoding the cardiac HERG/MiRP1 ion channel: implications for acquired and congenital long Q-T syndrome

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3292575

27 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/22396785

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Compendium of cardiac channel mutations in 541 consecutive unrelated patients referred for long QT syndrome genetic testing

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22396785

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Notched T waves on Holter recordings enhance detection of patients with LQt2 (HERG) mutations

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22396785

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0032654

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22396785%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

0 references

1 reference

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25 January 2020

PubMed publication ID

22396785

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22396785%20AND%20SRC:MED&resulttype=core&format=json