Development of a high-throughput assay for identifying inhibitors of TBK1 and IKKε (Q28481686)

1

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Melissa A Porter

2

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Adam W Cheely

3

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Xiaodong Wang

5

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Dmitri Kireev

6

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Albert S Baldwin

7

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William P Janzen

Creative Commons Attribution 4.0 International

8

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language of work or name

English

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publication date

2012

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published in

PLOS One

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volume

7

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issue

7

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page(s)

e41494

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copyright license

start time

30 July 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Emerging roles for the non-canonical IKKs in cancer

19 March 2017

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Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity

19 March 2017

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Regulation and function of IKK and IKK-related kinases

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Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity

19 March 2017

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

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IKKepsilon is part of a novel PMA-inducible IkappaB kinase complex

19 March 2017

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NAK is an IkappaB kinase-activating kinase

19 March 2017

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Signaling to NF-kappaB

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Inflammation meets cancer, with NF-κB as the matchmaker

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Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

7 April 2017

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IκB kinase α phosphorylation of TRAF4 downregulates innate immune signaling

7 April 2017

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Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity

29 September 2017

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Deregulation of IKBKE is associated with tumor progression, poor prognosis, and cisplatin resistance in ovarian cancer

29 September 2017

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Phosphorylation of the tumor suppressor CYLD by the breast cancer oncogene IKKepsilon promotes cell transformation

29 September 2017

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Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IkappaB kinase epsilon: a distinct upstream kinase mediates Ser-172 phosphorylation and activation

29 September 2017

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29 September 2017

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Phosphorylation of IRF-3 on Ser 339 generates a hyperactive form of IRF-3 through regulation of dimerization and CBP association

29 September 2017

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IkappaB kinase beta phosphorylates the K63 deubiquitinase A20 to cause feedback inhibition of the NF-kappaB pathway

29 September 2017

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Interferon regulatory factor 3 is regulated by a dual phosphorylation-dependent switch

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Determining protein kinase substrate specificity by parallel solution-phase assay of large numbers of peptide substrates

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Nuclear factor-kappaB and inhibitor of kappaB kinase pathways in oncogenic initiation and progression

29 September 2017

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RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival

29 September 2017

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A rapid method for determining protein kinase phosphorylation specificity

29 September 2017

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Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1.

29 September 2017

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Identification of Ser-386 of interferon regulatory factor 3 as critical target for inducible phosphorylation that determines activation

29 September 2017

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29 September 2017

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Recognizing molecules with drug-like properties

29 September 2017

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High-throughput biochemical kinase selectivity assays: panel development and screening applications.

29 September 2017

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10.1371/JOURNAL.PONE.0041494

27 November 2018

Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

3003167

ADS bibcode

2012PLoSO...741494H

0 references

OpenCitations bibliographic resource ID

3003167

1 reference