Rationale-Based Engineering of a Potent Long-Acting FGF21 Analog for the Treatment of Type 2 Diabetes (Q28485340)

1

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Yue-Sheng Li

2

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Jeonghoon Sun

3

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Ed Belouski

4

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Michael Hall

5

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Todd Hager

6

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Junming Yie

7

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Wei Wang

8

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Dwight Winters

9

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Stephen Smith

10

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Chris Spahr

11

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Lei-Ting Tam

12

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Zhongnan Shen

13

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Shanaka Stanislaus

14

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Narumol Chinookoswong

15

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Yvonne Lau

16

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Mark Leo Michaels

18

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Thomas Boone

19

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Murielle M Véniant

20

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Jing Xu

Creative Commons Attribution 4.0 International

21

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language of work or name

English

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publication date

2012

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published in

PLOS One

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volume

7

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issue

11

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page(s)

e49345

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copyright license

start time

27 November 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Circulating FGF21 levels are progressively increased from the early to end stages of chronic kidney diseases and are associated with renal function in Chinese

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Fibroblast growth factor 21 corrects obesity in mice

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Molecular genetic and biochemical analyses of FGF23 mutations in familial tumoral calcinosis

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Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver.

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Long-acting FGF21 has enhanced efficacy in diet-induced obese mice and in obese rhesus monkeys

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Mutant FGF-23 responsible for autosomal dominant hypophosphatemic rickets is resistant to proteolytic cleavage and causes hypophosphatemia in vivo.

21 January 2018

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10.1371/JOURNAL.PONE.0049345

27 November 2018

Identifiers

DOI

1 reference

4523974

ADS bibcode

2012PLoSO...749345H

0 references

4523974

1 reference

1 reference

1 reference