An ultra high-throughput, whole-animal screen for small molecule modulators of a specific genetic pathway in Caenorhabditis elegans (Q28487176)

1

0 references

Ying Wang

2

0 references

Siobhan Malany

3

0 references

Andrew Deonarine

4

0 references

Kevin Nguyen

5

0 references

Stefan Vasile

6

0 references

Keith P Choe

Creative Commons Attribution 4.0 International

7

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language of work or name

English

0 references

publication date

2013

0 references

published in

PLOS One

0 references

volume

8

0 references

issue

4

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page(s)

e62166

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copyright license

start time

29 April 2013

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Nrf2 knockdown by shRNA inhibits tumor growth and increases efficacy of chemotherapy in cervical cancer

29 September 2017

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High-throughput screening and biosensing with fluorescent C. elegans strains

29 September 2017

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29 September 2017

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29 September 2017

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The NRF2-mediated oxidative stress response pathway is associated with tumor cell resistance to arsenic trioxide across the NCI-60 panel.

29 September 2017

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A predictive model for drug bioaccumulation and bioactivity in Caenorhabditis elegans

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Increased age reduces DAF-16 and SKN-1 signaling and the hormetic response of Caenorhabditis elegans to the xenobiotic juglone

29 September 2017

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Exploratory drug safety: a discovery strategy to reduce attrition in development

29 September 2017

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Nrf2 enhances cell proliferation and resistance to anticancer drugs in human lung cancer

29 September 2017

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The WD40 repeat protein WDR-23 functions with the CUL4/DDB1 ubiquitin ligase to regulate nuclear abundance and activity of SKN-1 in Caenorhabditis elegans

29 September 2017

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Protective effects of a topical antioxidant mixture containing vitamin C, ferulic acid, and phloretin against ultraviolet-induced photodamage in human skin

29 September 2017

1 reference

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Distribution and physiology of ABC-type transporters contributing to multidrug resistance in bacteria

29 September 2017

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The versatile worm: genetic and genomic resources for Caenorhabditis elegans research

29 September 2017

1 reference

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Generation and characterization of a stable MK2-EGFP cell line and subsequent development of a high-content imaging assay on the Cellomics ArrayScan platform to screen for p38 mitogen-activated protein kinase inhibitors

29 September 2017

1 reference

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Caenorhabditis elegans: a versatile platform for drug discovery

29 September 2017

1 reference

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Fungal ATP-binding cassette (ABC) transporters in drug resistance & detoxification

29 September 2017

1 reference

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Uses of GFP in Caenorhabditis elegans

29 September 2017

1 reference

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Chemistry-to-gene screens in Caenorhabditis elegans

29 September 2017

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A practical note on the use of cytotoxicity assays.

29 September 2017

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Multidrug resistance in yeast Candida

29 September 2017

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The global burden of intestinal nematode infections--fifty years on.

29 September 2017

1 reference

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Parasitic nematode interactions with mammals and plants

29 September 2017

1 reference

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Model systems in drug discovery: chemical genetics meets genomics

29 September 2017

1 reference

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Transcriptional control of multidrug resistance in the yeast Saccharomyces

29 September 2017

1 reference

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SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response

29 September 2017

1 reference

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A stress-responsive glutathione S-transferase confers resistance to oxidative stress in Caenorhabditis elegans

29 September 2017

1 reference

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From genes to integrative physiology: ion channel and transporter biology in Caenorhabditis elegans

29 September 2017

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Drug resistance in yeasts--an emerging scenario

29 September 2017

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Caenorhabditis elegans: how good a model for veterinary parasites?

29 September 2017

1 reference

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High-throughput screening approaches for investigating drug metabolism and pharmacokinetics

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3639262

Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3639262

Direct observation of stress response in Caenorhabditis elegans using a reporter transgene

29 September 2017

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Cancer multidrug resistance

29 September 2017

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skn-1, a maternally expressed gene required to specify the fate of ventral blastomeres in the early C. elegans embryo

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3639262

ADMET rules of thumb II: A comparison of the effects of common substituents on a range of ADMET parameters

2 June 2018

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Caenorhabditis elegans as a model to screen plant extracts and compounds as natural anthelmintics for veterinary use.

21 January 2018

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Screening for presenilin inhibitors using the free-living nematode, Caenorhabditis elegans

21 January 2018

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Evolutionarily conserved WNK and Ste20 kinases are essential for acute volume recovery and survival after hypertonic shrinkage in Caenorhabditis elegans

21 January 2018

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Depletion of a nucleolar protein activates xenobiotic detoxification genes in Caenorhabditis elegans via Nrf /SKN-1 and p53/CEP-1.

21 January 2018

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Proteasomal dysfunction activates the transcription factor SKN-1 and produces a selective oxidative-stress response in Caenorhabditis elegans.

21 January 2018

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Acrylamide-responsive genes in the nematode Caenorhabditis elegans

21 January 2018

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The influence of water quality on the toxicity and degradation of juglone (5-hydroxy 1,4-naphthoquinone).

21 January 2018

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A rapid colorimetric assay for the quantitation of the viability of free-living larvae of nematodes in vitro.

21 January 2018

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The antioxidant activity of phloretin: the disclosure of a new antioxidant pharmacophore in flavonoids

21 January 2018

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Two faces of protein kinase Cδ: the contrasting roles of PKCδ in cell survival and cell death.

21 January 2018

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The C. elegans glycosyltransferase BUS-8 has two distinct and essential roles in epidermal morphogenesis.

21 January 2018

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An in vitro larval motility assay to determine anthelmintic sensitivity for human hookworm and Strongyloides species.

21 January 2018

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Extremely low dose of acrylamide decreases lifespan in Caenorhabditis elegans

27 November 2018

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Heat shock factor functions at the convergence of the stress response and developmental pathways in Caenorhabditis elegans.

27 November 2018

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Chalcones: structural requirements for antioxidant, estrogenic and antiproliferative activities

27 November 2018

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Hydrogen bond formation as basis for radical scavenging activity: a structure-activity study of C-methylated dihydrochalcones from Myrica gale and structurally related acetophenones

27 November 2018

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12 December 2020

Formation of a monomeric DNA binding domain by Skn-1 bZIP and homeodomain elements

1 reference

12 December 2020

Pharmacological promiscuity: dependence on compound properties and target specificity in a set of recent Roche compounds

1 reference

12 December 2020

Identification of neuroprotective compounds of caenorhabditis elegans dopaminergic neurons against 6-OHDA

1 reference

12 December 2020

Generation of a set of simple, interpretable ADMET rules of thumb

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0062166

Identifiers

DOI

1 reference

ADS bibcode

2013PLoSO...862166L

0 references

1 reference

1 reference

PubMed publication ID

23637990

1 reference