A genome-wide RNAi screen in Caenorhabditis elegans identifies the nicotinic acetylcholine receptor subunit ACR-7 as an antipsychotic drug target (Q28487183)

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English	A genome-wide RNAi screen in Caenorhabditis elegans identifies the nicotinic acetylcholine receptor subunit ACR-7 as an antipsychotic drug target	scientific article

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A genome-wide RNAi screen in Caenorhabditis elegans identifies the nicotinic acetylcholine receptor subunit ACR-7 as an antipsychotic drug target (English)

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Caenorhabditis elegans

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1 reference

based on heuristic

inferred from title

author name string

Taixiang Saur

1

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Sarah E DeMarco

2

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Angelica Ortiz

3

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Gregory R Sliwoski

4

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Limin Hao

5

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Xin Wang

6

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Bruce M Cohen

7

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Edgar A Buttner

8

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language of work or name

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publication date

2013

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9

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2

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e1003313

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copyright license

Creative Commons Attribution 4.0 International

28 February 2013

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April 2022 Public Data File from Crossref

copyright status

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Mammalian nicotinic acetylcholine receptors: from structure to function

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19 March 2017

Off-target effects of psychoactive drugs revealed by genome-wide assays in yeast

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Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia

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A C. elegans model of nicotine-dependent behavior: regulation by TRP-family channels

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Effectiveness of antipsychotic drugs in patients with chronic schizophrenia

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Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals novel gene functions

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19 March 2017

Systematic functional analysis of the Caenorhabditis elegans genome using RNAi

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alpha 7 nicotinic receptor transduces signals to phosphatidylinositol 3-kinase to block A beta-amyloid-induced neurotoxicity

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Assembly of human neuronal nicotinic receptor alpha5 subunits with alpha3, beta2, and beta4 subunits

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7 April 2017

Genome-wide RNAi screening in Caenorhabditis elegans

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7 April 2017

Muscarinic and nicotinic acetylcholine receptor agonists and allosteric modulators for the treatment of schizophrenia

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29 September 2017

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29 September 2017

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29 September 2017

Atypical antipsychotics as noncompetitive inhibitors of alpha4beta2 and alpha7 neuronal nicotinic receptors

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Structural and functional diversity of native brain neuronal nicotinic receptors

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Behavioral adaptation in C. elegans produced by antipsychotic drugs requires serotonin and is associated with calcium signaling and calcineurin inhibition

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The molecular and cellular neurobiology of nicotine abuse in schizophrenia

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29 September 2017

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29 September 2017

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The pipeline and future of drug development in schizophrenia.

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The nicotinic acetylcholine receptor gene family of the nematode Caenorhabditis elegans: an update on nomenclature

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29 September 2017

Schizophrenia and the alpha7 nicotinic acetylcholine receptor

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29 September 2017

Antipsychotic drugs disrupt normal development in Caenorhabditis elegans via additional mechanisms besides dopamine and serotonin receptors

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29 September 2017

A review and re-evaluation of an association between the NOTCH4 locus and schizophrenia

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Effectiveness of clozapine versus olanzapine, quetiapine, and risperidone in patients with chronic schizophrenia who did not respond to prior atypical antipsychotic treatment

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Functional genomics of the nicotinic acetylcholine receptor gene family of the nematode, Caenorhabditis elegans

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Ca2+ permeability of nicotinic acetylcholine receptors

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29 September 2017

The alpha7-nicotinic acetylcholine receptor and the pathology of hippocampal interneurons in schizophrenia

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Functional contribution of the alpha7 subunit to multiple subtypes of nicotinic receptors in embryonic chick sympathetic neurones.

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Nicotinic acetylcholine receptors in the nematode Caenorhabditis elegans

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Interacting genes required for pharyngeal excitation by motor neuron MC in Caenorhabditis elegans.

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29 September 2017

Antipsychotic drugs activate the C. elegans akt pathway via the DAF-2 insulin/IGF-1 receptor

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2 June 2018

Clozapine interaction with phosphatidyl inositol 3-kinase (PI3K)/insulin-signaling pathway in Caenorhabditis elegans

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2 June 2018

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2 June 2018

Evidence in postmortem brain tissue for decreased numbers of hippocampal nicotinic receptors in schizophrenia

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2 June 2018

Clozapine treatment for suicidality in schizophrenia: International Suicide Prevention Trial (InterSePT).

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Laminar distribution of nicotinic receptor subtypes in cortical regions in schizophrenia.

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21 January 2018

Antipsychotic clozapine inhibits the function of alpha7-nicotinic acetylcholine receptors

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21 January 2018

Anthelmintic actions on homomer-forming nicotinic acetylcholine receptor subunits: chicken alpha7 and ACR-16 from the nematode Caenorhabditis elegans.

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21 January 2018

Clozapine improves deficient inhibitory auditory processing in DBA/2 mice, via a nicotinic cholinergic mechanism

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Specific activation of the alpha 7 nicotinic acetylcholine receptor by a quaternary analog of cocaine.

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27 November 2018

Functional contribution of the alpha5 subunit to neuronal nicotinic channels expressed by chick sympathetic ganglion neurones.

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Serum levels of clozapine and norclozapine in patients treated with selective serotonin reuptake inhibitors

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27 November 2018

Tissue concentrations of clozapine and its metabolites in the rat

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27 November 2018

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10.1371/JOURNAL.PGEN.1003313

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Consolidated OpenCitations Corpus – April 2017

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Consolidated OpenCitations Corpus – April 2017

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Consolidated OpenCitations Corpus – April 2017

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Consolidated OpenCitations Corpus – April 2017

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