Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus (Q28505053)

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24 November 2019

title

Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus (English)

2 references

24 January 2017

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24 November 2019

1 reference

GOA release 2020-03-11

author

Michael R. Hayden

5

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6

Lisa M Ellerby

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24 November 2019

author name string

Juliette Gafni

1

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24 November 2019

Evan Hermel

2

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24 November 2019

Jessica E Young

3

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24 November 2019

Cheryl L Wellington

4

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24 November 2019

language of work or name

English

0 references

publication date

23 February 2004

1 reference

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Journal of Biological Chemistry

24 November 2019

published in

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24 January 2017

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volume

279

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issue

19

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page(s)

20211-20220

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

24 November 2019

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Evidence for degenerative and regenerative changes in neostriatal spiny neurons in Huntington's disease

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Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

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Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract

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Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates

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Mutant huntingtin enhances excitotoxic cell death.

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Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1

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Subtype-specific enhancement of NMDA receptor currents by mutant huntingtin

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Polyglutamine-expanded huntingtin promotes sensitization of N-methyl-D-aspartate receptors via post-synaptic density 95.

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In vitro effects of polyglutamine tracts on Ca2+-dependent depolarization of rat and human mitochondria: relevance to Huntington's disease.

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Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract

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The influence of huntingtin protein size on nuclear localization and cellular toxicity.

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Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells

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The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme

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Cutting to the chase: calpain proteases in cell motility

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The calpain family and human disease

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Calpain and caspase: can you tell the difference?

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Increased calpain expression in activated glial and inflammatory cells in experimental allergic encephalomyelitis

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Regional calpain and caspase-3 proteolysis of alpha-spectrin after traumatic brain injury

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Cross-talk between calpain and caspase proteolytic systems during neuronal apoptosis

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Proteolysis of the N-methyl-d-aspartate receptor by calpain in situ

21 January 2018

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Bid is cleaved by calpain to an active fragment in vitro and during myocardial ischemia/reperfusion

21 January 2018

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Direct cleavage by the calcium-activated protease calpain can lead to inactivation of caspases

21 January 2018

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Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus

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SOLH, a human homologue of the Drosophila melanogaster small optic lobes gene is a member of the calpain and zinc-finger gene families and maps to human chromosome 16p13.3 near CATM (cataract with microphthalmia)

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Characterization and expression of calpain 10. A novel ubiquitous calpain with nuclear localization

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Cleavage of atrophin-1 at caspase site aspartic acid 109 modulates cytotoxicity

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Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis.

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Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions

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Nuclear targeting of mutant Huntingtin increases toxicity

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Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice

21 January 2018

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Identifiers

DOI

10.1074/JBC.M401267200

2 references

Consolidated OpenCitations Corpus – April 2017

3992460

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24 November 2019

3992460

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

2 references

3992460