The influence of huntingtin protein size on nuclear localization and cellular toxicity. (Q41035353)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9606203%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

title

The influence of huntingtin protein size on nuclear localization and cellular toxicity (English)

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11 November 2019

8

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11 November 2019

Roshni Singaraja

2

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11 November 2019

author name string

A S Hackam

1

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11 November 2019

C L Wellington

3

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11 November 2019

M Metzler

4

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11 November 2019

K McCutcheon

5

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11 November 2019

T Zhang

6

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11 November 2019

M Kalchman

7

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11 November 2019

language of work or name

English

0 references

publication date

1 June 1998

1 reference

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11 November 2019

published in

Journal of Cell Biology

1 reference

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11 November 2019

volume

141

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11 November 2019

issue

5

1 reference

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11 November 2019

page(s)

1097-1105

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Truncated N-terminal fragments of huntingtin with expanded glutamine repeats form nuclear and cytoplasmic aggregates in cell culture.

11 November 2019

cites work

1 reference

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Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract

26 September 2017

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Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates

26 September 2017

1 reference

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Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures

26 September 2017

1 reference

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Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

26 September 2017

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Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

26 September 2017

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HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain

26 September 2017

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The nuclear localization sequences of the BRCA1 protein interact with the importin-alpha subunit of the nuclear transport signal receptor

26 September 2017

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Nucleocytoplasmic transport

26 September 2017

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Complex asparagine-linked oligosaccharides are required for morphogenic events during post-implantation development.

26 September 2017

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Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes

26 September 2017

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When more is less: pathogenesis of glutamine repeat neurodegenerative diseases

26 September 2017

1 reference

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Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

26 September 2017

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tRNA transport from the nucleus in a eukaryotic cell: carrier-mediated translocation process

26 September 2017

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Assembly in vitro of nuclei active in nuclear protein transport: ATP is required for nucleoplasmin accumulation.

26 September 2017

1 reference

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Nuclear targeting sequences--a consensus?

26 September 2017

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Absence of disease phenotype and intergenerational stability of the CAG repeat in transgenic mice expressing the human Huntington disease transcript

26 September 2017

1 reference

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Intranuclear neuronal inclusions in Huntington's disease and dentatorubral and pallidoluysian atrophy: correlation between the density of inclusions and IT15 CAG triplet repeat length

26 September 2017

1 reference

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Huntingtin localization in brains of normal and Huntington's disease patients

14 June 2018

1 reference

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Of molecular interactions, mice and mechanisms: new insights into Huntington's disease

14 June 2018

1 reference

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Human huntingtin derived from YAC transgenes compensates for loss of murine huntingtin by rescue of the embryonic lethal phenotype

14 June 2018

1 reference

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Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing

14 June 2018

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Tetrazolium-based assays for cellular viability: a critical examination of selected parameters affecting formazan production

14 June 2018

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Suppression of aggregate formation and apoptosis by transglutaminase inhibitors in cells expressing truncated DRPLA protein with an expanded polyglutamine stretch.

14 June 2018

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Rethinking genotype and phenotype correlations in polyglutamine expansion disorders

19 August 2018

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Intranuclear inclusions of expanded polyglutamine protein in spinocerebellar ataxia type 3.

19 August 2018

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Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo

19 August 2018

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Protein kinase C inhibitors induce apoptosis in human malignant glioma cell lines

19 August 2018

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Of molecular interactions, mice and mechanisms

19 August 2018

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Crossref

https://api.crossref.org/works/10.1083%2FJCB.141.5.1097

Synthetic peptides as nuclear localization signals

21 January 2018

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Crossref

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Kinetic characterization of the human retinoblastoma protein bipartite nuclear localization sequence (NLS) in vivo and in vitro. A comparison with the SV40 large T-antigen NLS

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/9606203

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1083/JCB.141.5.1097

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9606203%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

1 reference

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11 November 2019

PubMed publication ID

9606203

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9606203%20AND%20SRC:MED&resulttype=core&format=json