Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity (Q28506163)

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5 December 2019

title

Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity (English)

2 references

24 January 2017

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Protein kinase, DNA activated, catalytic polypeptide

5 December 2019

main subject

1 reference

severe combined immunodeficiency

GOA release 2020-03-11

1 reference

4

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5 December 2019

Stephen P Jackson

8

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5 December 2019

author name string

G E Taccioli

1

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5 December 2019

A G Amatucci

2

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5 December 2019

H J Beamish

3

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5 December 2019

X H Xiang

5

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5 December 2019

M I Torres Arzayus

6

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5 December 2019

A Priestley

7

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5 December 2019

A Marshak Rothstein

9

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5 December 2019

P A Jeggo

10

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5 December 2019

V L Herrera

11

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5 December 2019

language of work or name

English

0 references

publication date

1 September 1998

2 references

24 January 2017

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5 December 2019

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5 December 2019

volume

9

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5 December 2019

page(s)

355-366

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5 December 2019

issue

3

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The DNA-activated protein kinase -- DNA-PK

5 December 2019

cites work

1 reference

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7 January 2021

Nonsense mutation at Tyr-4046 in the DNA-dependent protein kinase catalytic subunit of severe combined immune deficiency mice

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7 January 2021

scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair

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7 January 2021

Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation.

1 reference

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Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse

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p53 is required for both radiation-induced differentiation and rescue of V(D)J rearrangement in scid mouse thymocytes

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Complementation of the ionizing radiation sensitivity, DNA end binding, and V(D)J recombination defects of double-strand break repair mutants by the p86 Ku autoantigen

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T-lymphocyte development in scid mice is arrested shortly after the initiation of T-cell receptor delta gene recombination

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A DNA-activated protein kinase from HeLa cell nuclei

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7 January 2021

Biochemical and genetic defects in the DNA-dependent protein kinase in murine scid lymphocytes

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Ku86 defines the genetic defect and restores X-ray resistance and V(D)J recombination to complementation group 5 hamster cell mutants

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7 January 2021

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The scid mutation in mice causes a general defect in DNA repair

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7 January 2021

A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination

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Development of CD4+CD8+ thymocytes in RAG-deficient mice through a T cell receptor beta chain-independent pathway

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7 January 2021

DNA-dependent protein kinase: DNA binding and activation in the absence of Ku

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7 January 2021

DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product

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7 January 2021

A link between double-strand break-related repair and V(D)J recombination: the scid mutation

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7 January 2021

DNA-PK: at the cross-roads of biochemistry and genetics

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7 January 2021

Menage à trois: double strand break repair, V(D)J recombination and DNA-PK.

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7 January 2021

DNA-PKcs: a T-cell tumour suppressor encoded at the mouse scid locus

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7 January 2021

p53 prevents maturation to the CD4+CD8+ stage of thymocyte differentiation in the absence of T cell receptor rearrangement.

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7 January 2021

DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect

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7 January 2021

The DNA-dependent protein kinase, DNA-PK: 10 years and no ends in sight

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The mechanism of V(D)J joining: lessons from molecular, immunological, and comparative analyses

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The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination

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7 January 2021

The defect in murine severe combined immune deficiency: joining of signal sequences but not coding segments in V(D)J recombination.

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7 January 2021

Transient restoration of gene rearrangement at multiple T cell receptor loci in gamma-irradiated scid mice

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The scid defect affects the final step of the immunoglobulin VDJ recombinase mechanism

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7 January 2021

The V(D)J recombination defect in the xrs-6 cell line results from a point mutation in the Ku80 gene

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination

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7 January 2021

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7 January 2021

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7 January 2021

Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates

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7 January 2021

Thymocyte differentiation in gamma-irradiated severe-combined immunodeficient mice: characterization of intermediates and products of V(D)J recombination at the T cell receptor alpha locus

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7 January 2021

Sublethal gamma-radiation induces differentiation of CD4-/CD8- into CD4+/CD8+ thymocytes without T cell receptor beta rearrangement in recombinase activation gene 2-/- mice

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7 January 2021

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Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9768755%20AND%20SRC:MED&resulttype=core&format=json

5 December 2019

2 references

24 January 2017