MAP kinases and mTOR mediate insulin-induced phosphorylation of insulin receptor substrate-1 on serine residues 307, 612 and 632 (Q28508130)

GOA release 2020-03-11

Junction plakoglobin

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https://scigraph.springernature.com/pub.10.1007/s00125-003-1223-4

GOA release 2020-03-11

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1

P. Gual

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24 January 2017

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T. Grémeaux

2

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24 January 2017

T. Gonzalez

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3

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24 January 2017

Y. Le Marchand-Brustel

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4

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24 January 2017

J.-F. Tanti

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5

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24 January 2017

1 November 2003

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24 January 2017

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24 January 2017

46

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24 January 2017

11

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24 January 2017

1532–1542

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24 January 2017

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cites work

Tyr(612) and Tyr(632) in human insulin receptor substrate-1 are important for full activation of insulin-stimulated phosphatidylinositol 3-kinase activity and translocation of GLUT4 in adipose cells

1 reference

12 December 2020

Serine/threonine phosphorylation of insulin receptor substrate 1 modulates insulin receptor signaling.

1 reference

12 December 2020

Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells

1 reference

12 December 2020

Positive and negative regulatory role of insulin receptor substrate 1 and 2 (IRS-1 and IRS-2) serine/threonine phosphorylation.

1 reference

12 December 2020

A central role for JNK in obesity and insulin resistance

1 reference

12 December 2020

Serine/threonine phosphorylation of IRS-1 triggers its degradation: possible regulation by tyrosine phosphorylation

1 reference

12 December 2020

Low cellular IRS 1 gene and protein expression predict insulin resistance and NIDDM.

1 reference

12 December 2020

Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle

1 reference

12 December 2020

Modulation of insulin receptor substrate-1 tyrosine phosphorylation and function by mitogen-activated protein kinase

1 reference

12 December 2020

Protein kinase C modulation of insulin receptor substrate-1 tyrosine phosphorylation requires serine 612.

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12 December 2020

The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)

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12 December 2020

Insulin resistance: a phosphorylation-based uncoupling of insulin signaling

1 reference

12 December 2020

Hyperosmotic stress inhibits insulin receptor substrate-1 function by distinct mechanisms in 3T3-L1 adipocytes

1 reference

12 December 2020

A PI3-kinase signaling code for insulin-triggered insertion of glucose transporters into the plasma membrane

1 reference

12 December 2020

Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex.

1 reference

12 December 2020

Salicylic acid reverses phorbol 12-myristate-13-acetate (PMA)- and tumor necrosis factor alpha (TNFalpha)-induced insulin receptor substrate 1 (IRS1) serine 307 phosphorylation and insulin resistance in human embryonic kidney 293 (HEK293) cells

1 reference

12 December 2020

Phosphorylation of insulin receptor substrate-1 on multiple serine residues, 612, 632, 662, and 731, modulates insulin action

1 reference

12 December 2020

Insulin receptor substrate (IRS) transduction system: distinct and overlapping signaling potential

1 reference

12 December 2020

Cross-talk between the platelet-derived growth factor and the insulin signaling pathways in 3T3-L1 adipocytes

1 reference

12 December 2020

Insulin signalling and the regulation of glucose and lipid metabolism

1 reference

12 December 2020

Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action

1 reference

12 December 2020

Substrate recognition determinants of the mitogen-activated 70K S6 kinase from rat liver

1 reference

12 December 2020

Modulation of insulin receptor substrate-1 tyrosine phosphorylation by an Akt/phosphatidylinositol 3-kinase pathway

1 reference

12 December 2020

Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in tumor necrosis factor-treated cells through targeting multiple serine kinases

1 reference

12 December 2020

Mammalian target of rapamycin pathway regulates insulin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and metabolic signals of insulin

1 reference

12 December 2020

IRS proteins and the common path to diabetes

1 reference

12 December 2020

Defect in skeletal muscle phosphatidylinositol-3-kinase in obese insulin-resistant mice

1 reference

12 December 2020

Diabetes mellitus and genetically programmed defects in beta-cell function

1 reference

12 December 2020

Regulation of insulin/insulin-like growth factor-1 signaling by proteasome-mediated degradation of insulin receptor substrate-2.

1 reference

12 December 2020

Defects of the insulin receptor substrate (IRS) system in human metabolic disorders

1 reference

12 December 2020

4E-BP1 and S6K1: translational integration sites for nutritional and hormonal information in muscle

1 reference

12 December 2020

c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade

1 reference

12 December 2020

Phosphorylation of insulin receptor substrate-1 (IRS-1) by protein kinase B positively regulates IRS-1 function

1 reference

12 December 2020

A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1.

1 reference

12 December 2020

Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by Serine 312 phosphorylation

1 reference

12 December 2020

Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K.

1 reference

12 December 2020

Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways

1 reference

12 December 2020

Target of rapamycin (TOR): balancing the opposing forces of protein synthesis and degradation

1 reference

12 December 2020

Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes

1 reference

12 December 2020

Cellular mechanisms of insulin resistance

1 reference

12 December 2020

Identification by mutation of the tyrosine residues in the insulin receptor substrate-1 affecting association with the tyrosine phosphatase 2C and phosphatidylinositol 3-kinase

1 reference

12 December 2020