Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice (Q28509000)

4 July 2017

title

Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice (English)

1 reference

Mitogen-activated protein kinase kinase 3

4 July 2017

main subject

1 reference

GOA release 2020-03-11

7

R A Flavell

1 reference

4 July 2017

6

R J Davis

1 reference

4 July 2017

H T Lu

1

1 reference

4 July 2017

D D Yang

2

1 reference

4 July 2017

M Wysk

3

1 reference

4 July 2017

E Gatti

4

1 reference

4 July 2017

I Mellman

5

1 reference

4 July 2017

language of work or name

English

0 references

publication date

1 April 1999

1 reference

4 July 2017

number of pages

13

1 reference

inferred from page(s)

published in

The EMBO Journal

1 reference

4 July 2017

volume

18

1 reference

4 July 2017

issue

7

1 reference

4 July 2017

page(s)

1845-1857

1 reference

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

4 July 2017

cites work

1 reference

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RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK)

19 March 2017

1 reference

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Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB

19 March 2017

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PRAK, a novel protein kinase regulated by the p38 MAP kinase

19 March 2017

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Regulation of immune responses by TGF-beta

19 March 2017

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19 March 2017

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Signal transduction by the c-Jun N-terminal kinase (JNK)--from inflammation to development

23 March 2017

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Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6

19 March 2017

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Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38delta

19 March 2017

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Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

19 March 2017

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Interferon consensus sequence binding protein-deficient mice display impaired resistance to intracellular infection due to a primary defect in interleukin 12 p40 induction

19 March 2017

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A cytoplasmic inhibitor of the JNK signal transduction pathway

19 March 2017

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Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases

19 March 2017

1 reference

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MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates

19 March 2017

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Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2

19 March 2017

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Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3

19 March 2017

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3pK, a novel mitogen-activated protein (MAP) kinase-activated protein kinase, is targeted by three MAP kinase pathways

19 March 2017

1 reference

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Purification and cDNA cloning of SAPKK3, the major activator of RK/p38 in stress- and cytokine-stimulated monocytes and epithelial cells

19 March 2017

1 reference

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Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation

19 March 2017

1 reference

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Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta)

19 March 2017

1 reference

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A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3

19 March 2017

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Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase

19 March 2017

1 reference

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Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase

19 March 2017

1 reference

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Characterization of the structure and function of a novel MAP kinase kinase (MKK6)

19 March 2017

1 reference

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The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factor

19 March 2017

1 reference

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The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells

19 March 2017

1 reference

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A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

19 March 2017

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A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells

19 March 2017

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Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms

19 March 2017

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MAP kinase pathways in yeast: for mating and more

19 March 2017

1 reference

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Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2

19 March 2017

1 reference

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Regulation of interleukin 12 p40 expression through an NF-kappa B half-site

19 March 2017

1 reference

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Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine

19 March 2017

1 reference

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The protein kinase family: conserved features and deduced phylogeny of the catalytic domains

19 March 2017

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Interleukin 1 is processed and released during apoptosis

19 March 2017

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Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells

19 March 2017

1 reference

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Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

19 March 2017

1 reference

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The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells

7 April 2017

1 reference

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Cellular responses to interferon-gamma

7 April 2017

1 reference

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Functional diversity of helper T lymphocytes

7 April 2017

1 reference

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Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages

7 April 2017

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A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

7 April 2017

1 reference

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Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity

7 April 2017

1 reference

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The search for physiological substrates of MAP and SAP kinases in mammalian cells

7 April 2017

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Human toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide

29 September 2017

1 reference

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p38 MAPK is required for CD40-induced gene expression and proliferation in B lymphocytes.

29 September 2017

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Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling

29 September 2017

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SEK1 deficiency reveals mitogen-activated protein kinase cascade crossregulation and leads to abnormal hepatogenesis

29 September 2017

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The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses

29 September 2017

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A conserved p38 mitogen-activated protein kinase pathway regulates Drosophila immunity gene expression

29 September 2017

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Interferon-gamma expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway

29 September 2017

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Synergistic regulation of the human interleukin-12 p40 promoter by NFkappaB and Ets transcription factors in Epstein-Barr virus-transformed B cells and macrophages.

29 September 2017

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p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways are required for nuclear factor-kappaB p65 transactivation mediated by tumor necrosis factor.

29 September 2017

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Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family

29 September 2017

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Interferon (IFN) consensus sequence-binding protein, a transcription factor of the IFN regulatory factor family, regulates immune responses in vivo through control of interleukin 12 expression

29 September 2017

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Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) is required for lipopolysaccharide stimulation of tumor necrosis factor alpha (TNF-alpha) translation: glucocorticoids inhibit TNF-alpha translation by blocking JNK/SAPK.

29 September 2017

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Molecular cloning and characterization of a novel p38 mitogen-activated protein kinase

29 September 2017

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Developmental regulation of MHC class II transport in mouse dendritic cells.

29 September 2017

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p38-2, a novel mitogen-activated protein kinase with distinct properties.

29 September 2017

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Multiple control elements mediate activation of the murine and human interleukin 12 p40 promoters: evidence of functional synergy between C/EBP and Rel proteins

29 September 2017

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The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase

29 September 2017

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T cell proliferation in response to interleukins 2 and 7 requires p38MAP kinase activation.

29 September 2017

1 reference

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Mitogen-activated protein (MAP) kinase regulates production of tumor necrosis factor-alpha and release of arachidonic acid in mast cells. Indications of communication between p38 and p42 MAP kinases

29 September 2017

1 reference

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Role of p38 and JNK mitogen-activated protein kinases in the activation of ternary complex factors

29 September 2017

1 reference

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Identification and characterization of a novel Ets-2-related nuclear complex implicated in the activation of the human interleukin-12 p40 gene promoter.

29 September 2017

1 reference

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Targeted disruption of the MKK4 gene causes embryonic death, inhibition of c-Jun NH2-terminal kinase activation, and defects in AP-1 transcriptional activity

29 September 2017

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Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation

29 September 2017

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Identification and characterization of a predominant isoform of human MKK3.

29 September 2017

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Fas activation of the p38 mitogen-activated protein kinase signalling pathway requires ICE/CED-3 family proteases

29 September 2017

1 reference

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SAP kinase-3, a new member of the family of mammalian stress-activated protein kinases

29 September 2017

1 reference

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Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways.

29 September 2017

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High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10.

29 September 2017

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Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

29 September 2017

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Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

29 September 2017

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Endotoxin signal transduction in macrophages.

29 September 2017

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Cloning and characterization of MEK6, a novel member of the mitogen-activated protein kinase kinase cascade

29 September 2017

1 reference

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Role of CSB/p38/RK stress response kinase in LPS and cytokine signaling mechanisms

29 September 2017

1 reference

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Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27.

29 September 2017

1 reference

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Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin

29 September 2017

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Differentiation of CD4+ T cells to Th1 cells requires MAP kinase JNK2.

29 September 2017

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Activation of the protein kinase p38 in the spindle assembly checkpoint and mitotic arrest.

2 June 2018

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Cytokines induce the development of functionally heterogeneous T helper cell subsets

2 June 2018

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Regulation and function of the JNK subgroup of MAP kinases

2 June 2018

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T-cell subsets: transcriptional control in the Th1/Th2 decision

2 June 2018

1 reference

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Cdc42Hs, but not Rac1, inhibits serum-stimulated cell cycle progression at G1/S through a mechanism requiring p38/RK.

2 June 2018

1 reference

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Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site

2 June 2018

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Innate immunity: impact on the adaptive immune response

2 June 2018

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Activation of stress-activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38)

2 June 2018

1 reference

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MEKKs, GCKs, MLKs, PAKs, TAKs, and tpls: upstream regulators of the c-Jun amino-terminal kinases?

2 June 2018

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A JNK signal transduction pathway that mediates morphogenesis and an immune response in Drosophila

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171270

The primary structure of p38 gamma: a new member of p38 group of MAP kinases

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171270

Induction of TH1 and TH2 immunity in neonatal mice.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171270

JNK is involved in signal integration during costimulation of T lymphocytes.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171270

Regulation of human cytolytic lymphocyte responses by interleukin-12

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171270

Differential roles of ERK and p38 MAP kinase pathways in positive and negative selection of T lymphocytes.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171270

Intrathymic signals in thymocytes are mediated by p38 mitogen-activated protein kinase.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171270

Regulation of murine macrophage IL-12 production. Activation of macrophages in vivo, restimulation in vitro, and modulation by other cytokines.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171270

Defective T Cell Differentiation in the Absence of Jnk1

27 November 2018

1 reference

12 December 2020

The p38 mitogen-activated protein kinase is activated by ligation of the T or B lymphocyte antigen receptors, Fas or CD40, but suppression of kinase activity does not inhibit apoptosis induced by antigen receptors

1 reference

12 December 2020

High-level IL-12 production by human dendritic cells requires two signals

1 reference

12 December 2020

Characterization of IL-12 receptor beta1 chain (IL-12Rbeta1)-deficient mice: IL-12Rbeta1 is an essential component of the functional mouse IL-12 receptor

1 reference

12 December 2020

Differential activation of extracellular signal-regulated kinase (ERK) 1, ERK2, p38, and c-Jun NH2-terminal kinase mitogen-activated protein kinases by bacterial peptidoglycan

1 reference

12 December 2020

Differential effects of LPS and CD40 ligand stimulations on the induction of IL-12 production by dendritic cells and macrophages

1 reference

12 December 2020

Apoptosis signaling pathway in T cells is composed of ICE/Ced-3 family proteases and MAP kinase kinase 6b

1 reference

12 December 2020

The p38-MAPK inhibitor, SB203580, inhibits cardiac stress-activated protein kinases/c-Jun N-terminal kinases (SAPKs/JNKs)

1 reference

12 December 2020

Interleukin-12: a cytokine at the interface of inflammation and immunity

1 reference

12 December 2020

Interferon regulatory factor-1 is required for a T helper 1 immune response in vivo

1 reference

12 December 2020

Multistage regulation of Th1-type immune responses by the transcription factor IRF-1

1 reference

12 December 2020

IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses

1 reference

12 December 2020

The regulation of CD4 T cell differentiation

1 reference

12 December 2020

Identifiers

DOI

10.1093/EMBOJ/18.7.1845

1 reference

4 July 2017

0 references

1 reference