ADAM metallopeptidase domain 17 (Q28561728)

From Wikidata

Jump to navigation Jump to search

mammalian protein found in Rattus norvegicus

a disintegrin and metallopeptidase domain 17
ADAM 17
a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme)
TNF-alpha convertase
TNF-alpha-converting enzyme
a disintegrin and metalloprotease domain 17
Adam17
disintegrin and metalloproteinase domain-containing protein 17

Language	Label	Description	Also known as
English	ADAM metallopeptidase domain 17	mammalian protein found in Rattus norvegicus	a disintegrin and metallopeptidase domain 17 ADAM 17 a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme) TNF-alpha convertase TNF-alpha-converting enzyme a disintegrin and metalloprotease domain 17 Adam17 disintegrin and metalloproteinase domain-containing protein 17

Statements

1 reference

25 May 2022

UniProt protein ID

disintegrin domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Z1K9

Metallopeptidase, catalytic domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Z1K9

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Peptidase M12B, ADAM/reprolysin, protein family

1 reference

based on heuristic

inferred from protein domain or family

ADAM10/ADAM17 catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

ADAM17, membrane-proximal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Disintegrin domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Peptidase M12B, propeptide family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

metalloendopeptidase activity

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1K9

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1K9

determination method or standard

peptidase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1K9

determination method or standard

hydrolase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1K9

determination method or standard

SH3 domain binding

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1K9

determination method or standard

metal ion binding

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1K9

determination method or standard

endopeptidase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1K9

determination method or standard

plasma membrane

determination method or standard

1 reference

8 April 2019

Metalloprotease disintegrin-mediated ectodomain shedding of EGFR ligands promotes intestinal epithelial restitution

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1K9

determination method or standard

determination method or standard

1 reference

8 April 2019

Involvement of TACE/ADAM17 and ADAM10 in etoposide-induced apoptosis of germ cells in rat spermatogenesis

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1K9

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1K9

determination method or standard

integral component of membrane

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1K9

determination method or standard

cytoplasmic vesicle

determination method or standard

1 reference

8 April 2019

A1 adenosine receptor-stimulated exocytosis in bladder umbrella cells requires phosphorylation of ADAM17 Ser-811 and EGF receptor transactivation.

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1K9

determination method or standard

apical part of cell

determination method or standard

1 reference

8 April 2019

A1 adenosine receptor-stimulated exocytosis in bladder umbrella cells requires phosphorylation of ADAM17 Ser-811 and EGF receptor transactivation.

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1K9

determination method or standard

biological process

determination method or standard

4 references

8 April 2019

ADAM-17 and TIMP3 protein and mRNA expression in spinal cord white matter of rats with acute experimental autoimmune encephalomyelitis

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1K9

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1K9

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1K9

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1K9

determination method or standard

membrane protein ectodomain proteolysis

determination method or standard

Notch signaling pathway

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1K9

determination method or standard

Notch receptor processing

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1K9

determination method or standard

spermatogenesis

determination method or standard

1 reference

8 April 2019

Differential expression and localization of ADAM10 and ADAM17 during rat spermatogenesis suggest a role in germ cell differentiation

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1K9

determination method or standard

positive regulation of neuron projection development

determination method or standard

1 reference

8 April 2019

TACE cleaves neogenin to desensitize cortical neurons to the repulsive guidance molecule.

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1K9

determination method or standard

receptor transactivation

determination method or standard

1 reference

8 April 2019

A1 adenosine receptor-stimulated exocytosis in bladder umbrella cells requires phosphorylation of ADAM17 Ser-811 and EGF receptor transactivation.

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1K9

determination method or standard

positive regulation of apoptotic process

determination method or standard

1 reference

8 April 2019

Involvement of TACE/ADAM17 and ADAM10 in etoposide-induced apoptosis of germ cells in rat spermatogenesis

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1K9

determination method or standard

negative regulation of apoptotic process

determination method or standard

1 reference

8 April 2019

TACE/ADAM17-TNF-alpha pathway in rat cortical cultures after exposure to oxygen-glucose deprivation or glutamate

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1K9

determination method or standard

positive regulation of ERK1 and ERK2 cascade

determination method or standard

1 reference

8 April 2019

ADAM17 silencing by adenovirus encoding miRNA-embedded siRNA revealed essential signal transduction by angiotensin II in vascular smooth muscle cells

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1K9

determination method or standard

response to antineoplastic agent

determination method or standard

1 reference

8 April 2019

Involvement of TACE/ADAM17 and ADAM10 in etoposide-induced apoptosis of germ cells in rat spermatogenesis

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1K9

determination method or standard

negative regulation of cold-induced thermogenesis

determination method or standard

1 reference

8 April 2019

Deficiency of TNFalpha converting enzyme (TACE/ADAM17) causes a lean, hypermetabolic phenotype in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1K9

determination method or standard

response to hypobaric hypoxia

determination method or standard

1 reference

8 April 2019

Differential expression of ADAM15 and ADAM17 metalloproteases in the rat brain after severe hypobaric hypoxia and hypoxic preconditioning

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1K9

determination method or standard

membrane protein ectodomain proteolysis

determination method or standard

3 references

8 April 2019

ADAM-17 and TIMP3 protein and mRNA expression in spinal cord white matter of rats with acute experimental autoimmune encephalomyelitis

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1K9

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1K9

determination method or standard

8 April 2019

Metalloprotease disintegrin-mediated ectodomain shedding of EGFR ligands promotes intestinal epithelial restitution

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1K9

determination method or standard

ADAM10/ADAM17 catalytic domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Z1K9

Peptidase M12B, propeptide

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Z1K9

Disintegrin domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Z1K9

ADAM17, membrane-proximal domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Z1K9

Peptidase M12B, ADAM/reprolysin

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Z1K9

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSRNOP00000073012

1 reference

ensembl Release 106

Ensembl protein ID

ENSRNOP00000073012

ENSRNOP00000089788

1 reference

ensembl Release 106

Ensembl protein ID

ENSRNOP00000089788

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q28561728&oldid=2023089258"