Deficiency of TNFalpha converting enzyme (TACE/ADAM17) causes a lean, hypermetabolic phenotype in mice (Q37325289)

19 August 2017

Deficiency of TNFalpha converting enzyme (TACE/ADAM17) causes a lean, hypermetabolic phenotype in mice (English)

1 reference

ADAM metallopeptidase domain 17

19 August 2017

1 reference

negative regulation of cold-induced thermogenesis

GOA release 2020-03-11

1 reference

A disintegrin and metallopeptidase domain 17

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

1 reference

Richard W Gelling

1

1 reference

19 August 2017

Wenbo Yan

2

1 reference

19 August 2017

Salwa Al-Noori

3

1 reference

19 August 2017

Aaron Pardini

4

1 reference

19 August 2017

Gregory J Morton

5

1 reference

19 August 2017

Kayoko Ogimoto

6

1 reference

19 August 2017

Michael W Schwartz

7

1 reference

19 August 2017

Peter J Dempsey

8

1 reference

19 August 2017

language of work or name

English

0 references

publication date

7 August 2008

1 reference

19 August 2017

1 reference

19 August 2017

149

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19 August 2017

12

1 reference

19 August 2017

6053-6064

1 reference

describes a project that uses

19 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2734496/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Maternal heparin-binding-EGF deficiency limits pregnancy success in mice.

6 September 2017

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Non-cell autonomous expression of TNF-alpha-converting enzyme ADAM17 is required for normal lymphocyte development

6 September 2017

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Central nervous system control of food intake and body weight

6 September 2017

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Regulatory circuits controlling white versus brown adipocyte differentiation

6 September 2017

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ADAMs as mediators of EGF receptor transactivation by G protein-coupled receptors

6 September 2017

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A pericellular collagenase directs the 3-dimensional development of white adipose tissue

6 September 2017

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The role of neuregulin-ErbB4 interactions on the proliferation and organization of cells in the subventricular zone

6 September 2017

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The melanocortin system during fasting.

6 September 2017

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Mammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM17-dependent shedding of epithelial amphiregulin

6 September 2017

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Muscle wasting in cardiac cachexia

6 September 2017

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ADAMs: key components in EGFR signalling and development

6 September 2017

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Receptor tyrosine kinase ErbB4 modulates neuroblast migration and placement in the adult forebrain

6 September 2017

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Epiregulin is not essential for development of intestinal tumors but is required for protection from intestinal damage

6 September 2017

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Phenotypic variation resulting from a deficiency of epidermal growth factor receptor in mice is caused by extensive genetic heterogeneity that can be genetically and molecularly partitioned

6 September 2017

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Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

6 September 2017

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Obesity wars: molecular progress confronts an expanding epidemic

6 September 2017

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Brown adipose tissue: function and physiological significance

6 September 2017

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Quantitative magnetic resonance (QMR) method for bone and whole-body-composition analysis

6 September 2017

1 reference

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Expression and function of tumour necrosis factor-alpha-converting enzyme in the central nervous system

6 September 2017

1 reference

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Beta-Adrenergic receptors, diet-induced thermogenesis, and obesity

6 September 2017

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Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling

6 September 2017

1 reference

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Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function

6 September 2017

1 reference

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Matrix metalloproteinases are differentially expressed in adipose tissue during obesity and modulate adipocyte differentiation

6 September 2017

1 reference

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The ADAMs family of metalloproteases: multidomain proteins with multiple functions

6 September 2017

1 reference

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Phenotypic analysis of Meltrin alpha (ADAM12)-deficient mice: involvement of Meltrin alpha in adipogenesis and myogenesis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2734496

betaAR signaling required for diet-induced thermogenesis and obesity resistance

6 September 2017

1 reference

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ADAM 12 protease induces adipogenesis in transgenic mice

6 September 2017

1 reference

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Metalloproteases and adipogenesis: a weighty subject

6 September 2017

1 reference

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Tumor necrosis factor-alpha converting enzyme (TACE) regulates epidermal growth factor receptor ligand availability

6 September 2017

1 reference

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Metalloprotease-disintegrin (ADAM) genes are widely and differentially expressed in the adult CNS

6 September 2017

1 reference

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Tumor necrosis factor-alpha-converting enzyme is required for cleavage of erbB4/HER4

6 September 2017

1 reference

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Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development

6 September 2017

1 reference

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Obesity and diabetes in TNF-alpha receptor- deficient mice

6 September 2017

1 reference

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TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation

6 September 2017

1 reference

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Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function

6 September 2017

1 reference

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Characterization of tumor necrosis factor-deficient mice

6 September 2017

1 reference

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A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells

6 September 2017

1 reference

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Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune re

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2734496

Regulation of fat and muscle development by transforming growth factor alpha in transgenic mice and in cultured cells.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2734496

Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2734496

Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2734496

Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2734496

Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2734496

Timp3 deficiency in insulin receptor-haploinsufficient mice promotes diabetes and vascular inflammation via increased TNF-alpha

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2734496

Post-transcriptional up-regulation of ADAM17 upon epidermal growth factor receptor activation and in breast tumors.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2734496

An assessment of ADAMs in bone cells: absence of TACE activity prevents osteoclast recruitment and the formation of the marrow cavity in developing long bones

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2734496

Structural features and biochemical properties of TNF-alpha converting enzyme (TACE).

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2734496

Pref-1, a preadipocyte secreted factor that inhibits adipogenesis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2734496

Lipin expression preceding peroxisome proliferator-activated receptor-gamma is critical for adipogenesis in vivo and in vitro.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2734496

Differential expression of plasminogen activator inhibitor-1, tumor necrosis factor-alpha, TNF-alpha converting enzyme and ADAMTS family members in murine fat territories

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2734496

Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2734496

Abnormal astrocyte development and neuronal death in mice lacking the epidermal growth factor receptor

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2734496

Mice with a null mutation of the TGF alpha gene have abnormal skin architecture, wavy hair, and curly whiskers and often develop corneal inflammation.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2734496

Mice heterozygous for tumor necrosis factor-alpha converting enzyme are protected from obesity-induced insulin resistance and diabetes.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2734496

Expanding the body mass range: associations between BMR and tissue morphology in wild type and mutant dwarf mice (David mice).

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2734496

Hypothalamic tumor necrosis factor-alpha converting enzyme mediates excitatory amino acid-dependent neuron-to-glia signaling in the neuroendocrine brain.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2734496

Central administration of transforming growth factor-alpha and neuregulin-1 suppress active behaviors and cause weight loss in hamsters

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2734496

The mitochondrial uncoupling-protein homologues.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2734496

Role of meltrin {alpha} (ADAM12) in obesity induced by high- fat diet

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2734496

Wa5 is a novel ENU-induced antimorphic allele of the epidermal growth factor receptor

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2734496

Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates GPIbalpha shedding from platelets in vitro and in vivo

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2734496

Behavioral characteristics of a nervous system-specific erbB4 knock-out mouse

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2734496

Evaluation of a quantitative magnetic resonance method for mouse whole body composition analysis.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2734496

A novel missense mutation in the mouse growth hormone gene causes semidominant dwarfism, hyperghrelinemia, and obesity

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2734496

TACE is required for fetal murine cardiac development and modeling

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2734496

Arcuate Nucleus-Specific Leptin Receptor Gene Therapy Attenuates the Obesity Phenotype of Koletsky (fak/fak) Rats

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2734496

Deficiency of tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) impairs nutritionally induced obesity in mice.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2734496

Analysis of energy expenditure at different ambient temperatures in mice lacking DGAT1.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2734496

Membrane-bound TNF supports secondary lymphoid organ structure but is subservient to secreted TNF in driving autoimmune inflammation.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2734496

Neuronal localization of the TNFalpha converting enzyme (TACE) in brain tissue and its correlation to amyloid plaques

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2734496

Pulmonary hypoplasia in mice lacking tumor necrosis factor-alpha converting enzyme indicates an indispensable role for cell surface protein shedding during embryonic lung branching morphogenesis

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2734496

Targeted disruption of the tumor necrosis factor-alpha gene: metabolic consequences in obese and nonobese mice.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2734496

Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2734496

Effect of matrix metalloproteinase inhibition on adipose tissue development

2 September 2018

1 reference

12 December 2020

Turning WAT into BAT gets rid of fat

1 reference

12 December 2020

Colonic Epithelial Expression of ErbB2 Is Required for Postnatal Maintenance of the Enteric Nervous System

1 reference

12 December 2020

Evaluation of the contributions of ADAMs 9, 12, 15, 17, and 19 to heart development and ectodomain shedding of neuregulins beta1 and beta2

1 reference

12 December 2020

Metabolic and cellular plasticity in white adipose tissue I: effects of beta3-adrenergic receptor activation

1 reference

12 December 2020

Cutting edge: TNF-alpha-converting enzyme (TACE/ADAM17) inactivation in mouse myeloid cells prevents lethality from endotoxin shock

1 reference

12 December 2020

Abnormal TNF activity in Timp3 −/− mice leads to chronic hepatic inflammation and failure of liver regeneration

1 reference

12 December 2020

Strain-dependent epithelial defects in mice lacking the EGF receptor

1 reference

12 December 2020

Role of lymphotoxin and the type I TNF receptor in the formation of germinal centers

1 reference

12 December 2020

An essential role for ectodomain shedding in mammalian development

1 reference

12 December 2020

Transmembrane tumor necrosis factor (TNF)-alpha inhibits adipocyte differentiation by selectively activating TNF receptor 1

1 reference

12 December 2020

Identifiers

DOI

10.1210/EN.2008-0775

1 reference

19 August 2017

1 reference

19 August 2017

1 reference