GEBR-7b, a novel PDE4D selective inhibitor that improves memory in rodents at non-emetic doses (Q28564847)

31 January 2017

title

GEBR-7b, a novel PDE4D selective inhibitor that improves memory in rodents at non-emetic doses (English)

1 reference

31 January 2017

O. Bruno

1

1 reference

31 January 2017

E. Fedele

2

1 reference

31 January 2017

J. Prickaerts

3

1 reference

31 January 2017

L. A. Parker

4

1 reference

31 January 2017

E. Canepa

5

1 reference

31 January 2017

C. Brullo

6

1 reference

31 January 2017

A. Cavallero

7

1 reference

31 January 2017

E. Gardella

8

1 reference

31 January 2017

A. Balbi

9

1 reference

31 January 2017

C. Domenicotti

10

1 reference

31 January 2017

E. Bollen

11

1 reference

31 January 2017

H. J. M. Gijselaers

12

1 reference

31 January 2017

T. Vanmierlo

13

1 reference

31 January 2017

K. Erb

14

1 reference

31 January 2017

C. L. Limebeer

15

1 reference

31 January 2017

F. Argellati

16

1 reference

31 January 2017

U. M. Marinari

17

1 reference

31 January 2017

M. A. Pronzato

18

1 reference

31 January 2017

R. Ricciarelli

19

1 reference

31 January 2017

language of work or name

English

0 references

publication date

1 December 2011

1 reference

British Journal of Pharmacology

31 January 2017

published in

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31 January 2017

volume

164

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31 January 2017

issue

8

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31 January 2017

page(s)

2054–2063

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Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety

31 January 2017

cites work

1 reference

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19 March 2017

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Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus

19 March 2017

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19 March 2017

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A mouse model of Rubinstein-Taybi syndrome: defective long-term memory is ameliorated by inhibitors of phosphodiesterase 4

19 March 2017

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19 March 2017

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Deletion of phosphodiesterase 4D in mice shortens alpha(2)-adrenoceptor-mediated anesthesia, a behavioral correlate of emesis

19 March 2017

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19 March 2017

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Cyclic AMP phosphodiesterases are localized in regions of the mouse brain associated with reinforcement, movement, and affect

19 March 2017

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Rolipram, a type IV-specific phosphodiesterase inhibitor, facilitates the establishment of long-lasting long-term potentiation and improves memory

19 March 2017

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The human area postrema and other nuclei related to the emetic reflex express cAMP phosphodiesterases 4B and 4D.

19 March 2017

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Selective phosphodiesterase inhibitors: a promising target for cognition enhancement.

29 September 2017

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Correlation between emetic effect of phosphodiesterase 4 inhibitors and their occupation of the high-affinity rolipram binding site in Suncus murinus brain

29 September 2017

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Conditioned gaping in rats: a selective measure of nausea

29 September 2017

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Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment

29 September 2017

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Overexpression of type-1 adenylyl cyclase in mouse forebrain enhances recognition memory and LTP.

29 September 2017

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PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization

29 September 2017

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Phosphodiesterase type 4 isozymes expression in human brain examined by in situ hybridization histochemistry and[3H]rolipram binding autoradiography. Comparison with monkey and rat brain

29 September 2017

1 reference

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PDE4 inhibitors induce emesis in ferrets via a noradrenergic pathway

29 September 2017

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Recruitment of long-lasting and protein kinase A-dependent long-term potentiation in the CA1 region of hippocampus requires repeated tetanization.

29 September 2017

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Toward a molecular definition of long-term memory storage

29 September 2017

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Requirement of a critical period of transcription for induction of a late phase of LTP.

29 September 2017

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A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data

29 September 2017

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The taste reactivity test. I. Mimetic responses to gustatory stimuli in neurologically normal rats

29 September 2017

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Phosphodiesterase-4D knock-out and RNA interference-mediated knock-down enhance memory and increase hippocampal neurogenesis via increased cAMP signaling

29 September 2017

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Effects of cAMP simulate a late stage of LTP in hippocampal CA1 neurons.

3 June 2018

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Rolipram in major depressive disorder: results of a double-blind comparative study with imipramine

3 June 2018

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New selective phosphodiesterase 4D inhibitors differently acting on long, short, and supershort isoforms.

3 June 2018

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Inhibition of phosphodiesterase-4 reverses memory deficits produced by Aβ25-35 or Aβ1-40 peptide in rats

21 January 2018

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Acute gamma-secretase inhibition improves contextual fear conditioning in the Tg2576 mouse model of Alzheimer's disease.

21 January 2018

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Enrichment improves cognition in AD mice by amyloid-related and unrelated mechanisms.

21 January 2018

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21 January 2018

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21 January 2018

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Localization of phosphodiesterase-4 isoforms in the medulla and nodose ganglion of the squirrel monkey.

21 January 2018

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Potential of the rat model of conditioned gaping to detect nausea produced by rolipram, a phosphodiesterase-4 (PDE4) inhibitor

21 January 2018

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Time-dependent involvement of cAMP and cGMP in consolidation of object memory: studies using selective phosphodiesterase type 2, 4 and 5 inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2011.01524.X

Enhanced long-term potentiation and impaired learning in phosphodiesterase 4D-knockout (PDE4D) mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2011.01524.X

Phosphodiesterase inhibitors enhance object memory independent of cerebral blood flow and glucose utilization in rats

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1476-5381.2011.01524.X

Performance of different mouse strains in an object recognition task

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1476-5381.2011.01524.X

Liver X receptor activation restores memory in aged AD mice without reducing amyloid.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2011.01524.X

Effects of phosphodiesterase inhibition on cortical spreading depression and associated changes in extracellular cyclic GMP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2011.01524.X

Effects of the novel PDE4 inhibitors MEM1018 and MEM1091 on memory in the radial-arm maze and inhibitory avoidance tests in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2011.01524.X

Antidepressant-like profile and reduced sensitivity to rolipram in mice deficient in the PDE4D phosphodiesterase enzyme

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246667

Inhibition of cyclic AMP phosphodiesterase (PDE4) reverses memory deficits associated with NMDA receptor antagonism

27 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/21649644

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Results of a phase II study of the antidepressant effect of rolipram

1 reference

https://pubmed.ncbi.nlm.nih.gov/21649644

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1111/J.1476-5381.2011.01524.X

1 reference

31 January 2017

0 references

1 reference