The transcription factor PAX4 acts as a survival gene in INS-1E insulinoma cells (Q28567289)

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24 December 2019

title

The transcription factor PAX4 acts as a survival gene in INS-1E insulinoma cells (English)

2 references

31 January 2017

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24 December 2019

1 reference

5

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24 December 2019

author name string

Brun T

1

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24 December 2019

Duhamel DL

2

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24 December 2019

Hu He KH

3

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24 December 2019

Wollheim CB

4

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24 December 2019

language of work or name

English

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publication date

29 January 2007

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24 December 2019

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31 January 2017

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24 December 2019

volume

26

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24 December 2019

issue

29

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24 December 2019

page(s)

4261-4271

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The diabetes-linked transcription factor PAX4 promotes {beta}-cell proliferation and survival in rat and human islets

24 December 2019

cites work

1 reference

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The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the alpha- and beta-cell lineages in the mouse endocrine pancreas

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Beta-cell dysfunction in late-onset diabetic subjects carrying homozygous mutation in transcription factors NeuroD1 and Pax4

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Transcriptional modulation of the anti-apoptotic protein BCL-XL by the paired box transcription factors PAX3 and PAX3/FKHR

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Expression of dominant negative form of PAX4 in human insulinoma

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A missense mutation of Pax4 gene (R121W) is associated with type 2 diabetes in Japanese

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PAX4 mutation (R121W) as a prodiabetic variant in Okinawans

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The concerted activities of Pax4 and Nkx2.2 are essential to initiate pancreatic beta-cell differentiation

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Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation

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Specificity and versatility in tgf-beta signaling through Smads

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Activation of the interferon system by short-interfering RNAs

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Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines

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7 January 2021

Phosphorylated inositol compounds in beta -cell stimulus-response coupling

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Induction of apoptosis in rhabdomyosarcoma cells through down-regulation of PAX proteins.

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Association of childhood type 1 diabetes mellitus with a variant of PAX4: possible link to beta cell regenerative capacity

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Glucagon-like peptide 1 induces pancreatic beta-cell proliferation via transactivation of the epidermal growth factor receptor

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Opposing actions of Arx and Pax4 in endocrine pancreas development

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Cholesteryl ester transfer protein gene expression during differentiation of human preadipocytes to adipocytes in primary culture.

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Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes

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Transfection of melanoma cells with antisense PAX3 oligonucleotides additively complements cisplatin-induced cytotoxicity

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A moderate reduction of Bcl-x(L) expression protects against tumorigenesis; however, it also increases susceptibility to tissue injury

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Insulin-like growth factor I (IGF-I)-stimulated pancreatic beta-cell growth is glucose-dependent. Synergistic activation of insulin receptor substrate-mediated signal transduction pathways by glucose and IGF-I in INS-1 cells

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7 January 2021

Growth factor-mediated proliferation and differentiation of insulin-producing INS-1 and RINm5F cells: identification of betacellulin as a novel beta-cell mitogen

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NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice

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PAX4 gene variations predispose to ketosis-prone diabetes

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Glucose Sensitivity and Metabolism-Secretion Coupling Studied during Two-Year Continuous Culture in INS-1E Insulinoma Cells

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Paired-Box genes are frequently expressed in cancer and often required for cancer cell survival

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The Pax4 gene is essential for differentiation of insulin-producing β cells in the mammalian pancreas

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Identifiers

DOI

10.1038/SJ.ONC.1210205

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17260022%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

24 December 2019

0 references

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17260022%20AND%20SRC:MED&resulttype=core&format=json