Mutation of active site residues of insulin-degrading enzyme alters allosteric interactions (Q28570444)

31 January 2017

title

Mutation of active site residues of insulin-degrading enzyme alters allosteric interactions (English)

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31 January 2017

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Eun Suk Song

1

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31 January 2017

Abigail Daily

2

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31 January 2017

Michael G. Fried

3

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31 January 2017

Maria Aparecida Juliano

4

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31 January 2017

Luiz Juliano

5

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31 January 2017

Louis B. Hersh

6

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31 January 2017

language of work or name

English

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publication date

6 May 2005

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Journal of Biological Chemistry

31 January 2017

published in

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31 January 2017

volume

280

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31 January 2017

issue

18

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31 January 2017

page(s)

17701–17706

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Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

31 January 2017

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Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease

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Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition

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Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo

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Identification of gamma-endorphin-generating enzyme as insulin-degrading enzyme

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Substrate activation of insulin-degrading enzyme (insulysin). A potential target for drug development.

21 January 2018

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21 January 2018

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21 January 2018

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Mutation of active site residues of the puromycin-sensitive aminopeptidase: conversion of the enzyme into a catalytically inactive binding protein.

21 January 2018

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ATP effects on insulin-degrading enzyme are mediated primarily through its triphosphate moiety

21 January 2018

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Leukotriene A4 hydrolase: abrogation of the peptidase activity by mutation of glutamic acid-296

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21 January 2018

Identifiers

DOI

10.1074/JBC.M501896200

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31 January 2017

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