AMP-activated protein kinase and pancreatic/duodenal homeobox-1 involved in insulin secretion under high leucine exposure in rat insulinoma beta-cells (Q28574064)

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English	AMP-activated protein kinase and pancreatic/duodenal homeobox-1 involved in insulin secretion under high leucine exposure in rat insulinoma beta-cells	scientific journal article

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scholarly article

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31 January 2017

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28 January 2020

AMP-activated protein kinase and pancreatic/duodenal homeobox-1 involved in insulin secretion under high leucine exposure in rat insulinoma beta-cells (English)

2 references

31 January 2017

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28 January 2020

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9

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28 January 2020

author name string

Xiujuan Zhang

1

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31 January 2017

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28 January 2020

Nannan Sun

2

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28 January 2020

Laicheng Wang

3

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28 January 2020

Hua Guo

4

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28 January 2020

Qingbo Guan

5

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28 January 2020

Bin Cui

6

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31 January 2017

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28 January 2020

Limin Tian

7

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28 January 2020

Ling Gao

8

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28 January 2020

publication date

1 April 2009

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28 January 2020

Journal of Cellular and Molecular Medicine

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31 January 2017

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28 January 2020

13

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28 January 2020

4

2 references

31 January 2017

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28 January 2020

758-770

1 reference

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28 January 2020

Peroxisome proliferator-activated receptor-alpha regulates the expression of pancreatic/duodenal homeobox-1 in rat insulinoma (INS-1) cells and ameliorates glucose-induced insulin secretion impaired by palmitate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3822882

19 March 2017

Cytotoxicity of psammaplin A from a two-sponge association may correlate with the inhibition of DNA replication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3822882

19 March 2017

Regulation of insulin gene transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3822882

19 March 2017

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

1 reference

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19 March 2017

Pdx1 level defines pancreatic gene expression pattern and cell lineage differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3822882

19 March 2017

AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3822882

19 March 2017

Purification of the beta-cell glucose-sensitive factor that transactivates the insulin gene differentially in normal and transformed islet cells

1 reference

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19 March 2017

PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum

1 reference

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7 April 2017

Insulin-promoter-factor 1 is required for pancreas development in mice

1 reference

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7 April 2017

Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines

1 reference

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7 April 2017

Inhibition of AMP-activated protein kinase protects pancreatic beta-cells from cytokine-mediated apoptosis and CD8+ T-cell-induced cytotoxicity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3822882

29 September 2017

Crucial role of PDX-1 in pancreas development, beta-cell differentiation, and induction of surrogate beta-cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3822882

29 September 2017

An optimized in vitro assay for screening compounds that stimulate liver cell glucose utilization with low cytotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3822882

29 September 2017

The role of AMPK and mTOR in nutrient sensing in pancreatic beta-cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3822882

29 September 2017

Functional analysis of human glucokinase gene mutations causing MODY2: exploring the regulatory mechanisms of glucokinase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3822882

29 September 2017

Leucine stimulates mammalian target of rapamycin signaling in C2C12 myoblasts in part through inhibition of adenosine monophosphate-activated protein kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3822882

29 September 2017

AICAR potentiates ROS production induced by chronic high glucose: roles of AMPK in pancreatic beta-cell apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3822882

29 September 2017

Exposure to chronic high glucose induces beta-cell apoptosis through decreased interaction of glucokinase with mitochondria: downregulation of glucokinase in pancreatic beta-cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3822882

29 September 2017

Glucose concentration and AMP-dependent kinase activation regulate expression of insulin receptor family members in rat islets and INS-1E beta cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3822882

29 September 2017

Suppression of Pdx-1 perturbs proinsulin processing, insulin secretion and GLP-1 signalling in INS-1 cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3822882

29 September 2017

Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3822882

29 September 2017

Cell lines derived from pancreatic islets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3822882

29 September 2017

Leucine culture reveals that ATP synthase functions as a fuel sensor in pancreatic beta-cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3822882

29 September 2017

Long-Term exposure of INS-1 cells to cis and trans fatty acids influences insulin release and fatty acid oxidation differentially

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3822882

29 September 2017

Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3822882

29 September 2017

AMP-activated protein kinase regulates gene expression by direct phosphorylation of nuclear proteins

1 reference

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29 September 2017

Comparison of the secretory properties of four insulin-secreting cell lines

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29 September 2017

The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways.

1 reference

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29 September 2017

Differential impact of acute and chronic lipotoxicity on gene expression in INS-1 cells.

1 reference

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29 September 2017

Glucagon-like peptide 1 elevates cytosolic calcium in pancreatic beta-cells independently of protein kinase A.

1 reference

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29 September 2017

AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic beta cells, and may regulate insulin release.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3822882

29 September 2017

Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3822882

29 September 2017

Induction by glucose of genes coding for glycolytic enzymes in a pancreatic beta-cell line (INS-1).

1 reference

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29 September 2017

Transcriptional activation of the GLUT2 gene by the IPF-1/STF-1/IDX-1 homeobox factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3822882

29 September 2017

The effect of L-leucine on the absorption of levodopa, studied by regional jejunal perfusion in man.

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29 September 2017

Chronic hyperglycemia is associated with impaired glucose influence on insulin secretion. A study in normal rats using chronic in vivo glucose infusions

1 reference

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29 September 2017

Interaction of Amino Acids with Glycyl-l-leucine Hydrolysis and Transport in Monkey Small Intestine

1 reference

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29 September 2017

L-leucine or its keto acid potentiate but do not initiate insulin release in chicken.

1 reference

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3 June 2018

Regulation of glucokinase and GLUT-2 glucose-transporter gene expression in pancreatic B-cells

1 reference

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3 June 2018

Transcriptional mechanism of suppression of insulin gene expression by AMP-activated protein kinase activator 5-amino-4-imidazolecarboxamide riboside (AICAR) in beta-cells.

1 reference

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27 November 2018

Environmental causes of type 1 diabetes

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27 November 2018

Glucose-induced repression of PPAR gene expression in pancreatic -cells involves PP2A activation and AMPK inactivation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3822882

27 November 2018

Leucine regulation of glucokinase and ATP synthase sensitizes glucose-induced insulin secretion in pancreatic beta-cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3822882

27 November 2018

High-fat diet feeding impairs both the expression and activity of AMPKa in rats' skeletal muscle

1 reference

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27 November 2018

Over-expression of AMP-activated protein kinase impairs pancreatic {beta}-cell function in vivo

1 reference

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27 November 2018

An insulin-degrading enzyme inhibitor decreases amylin degradation, increases amylin-induced cytotoxicity, and increases amyloid formation in insulinoma cell cultures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3822882

27 November 2018

Chronic exposure to high leucine impairs glucose-induced insulin release by lowering the ATP-to-ADP ratio

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3822882

27 November 2018

Palmitate activates AMP-activated protein kinase and regulates insulin secretion from beta cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19438972

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fatty acids decrease IDX-1 expression in rat pancreatic islets and reduce GLUT2, glucokinase, insulin, and somatostatin levels

1 reference

https://pubmed.ncbi.nlm.nih.gov/19438972

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transgenic reexpression of GLUT1 or GLUT2 in pancreatic beta cells rescues GLUT2-null mice from early death and restores normal glucose-stimulated insulin secretion

1 reference

https://pubmed.ncbi.nlm.nih.gov/19438972

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucose uptake, utilization, and signaling in GLUT2-null islets

1 reference

https://pubmed.ncbi.nlm.nih.gov/19438972

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of pancreatic beta-cell electrical activity and insulin release by physiological amino acid concentrations

1 reference

https://pubmed.ncbi.nlm.nih.gov/19438972

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of supraphysiologic concentration glucose on pancreatic duodenal homeobox-1 expression and insulin secretion in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/19438972

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Causes of diabetes in children and adolescents. A combination of heredity and environment]

1 reference

https://pubmed.ncbi.nlm.nih.gov/19438972

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1582-4934.2009.00656.X

2 references

31 January 2017

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19438972%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19438972%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

2 references

31 January 2017

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19438972%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

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