Nuclear protein LEDGF/p75 recognizes supercoiled DNA by a novel DNA-binding domain (Q28578569)

31 January 2017

title

Nuclear protein LEDGF/p75 recognizes supercoiled DNA by a novel DNA-binding domain (English)

1 reference

31 January 2017

main subject

supercoiled DNA binding

1 reference

Gene Ontology release 2020-05-02

Kimiko M. Tsutsui

1

1 reference

31 January 2017

Kuniaki Sano

2

1 reference

31 January 2017

Osamu Hosoya

3

1 reference

31 January 2017

Tadashi Miyamoto

4

1 reference

31 January 2017

Ken Tsutsui

5

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31 January 2017

language of work or name

English

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publication date

1 July 2011

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31 January 2017

published in

Nucleic Acids Research

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31 January 2017

volume

39

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31 January 2017

issue

12

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31 January 2017

page(s)

5067–5081

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Creative Commons Attribution-NonCommercial 2.5 Generic

31 January 2017

copyright license

start time

7 November 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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17 March 2017

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Transcriptional co-activator LEDGF interacts with Cdc7-activator of S-phase kinase (ASK) and stimulates its enzymatic activity

17 March 2017

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LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration

17 March 2017

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A tripartite DNA-binding element, comprised of the nuclear localization signal and two AT-hook motifs, mediates the association of LEDGF/p75 with chromatin in vivo

17 March 2017

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Functional domains of the yeast chromatin protein Sin1p/Spt2p can bind four-way junction and crossing DNA structures

17 March 2017

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Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase

17 March 2017

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Retroviral DNA integration: ASLV, HIV, and MLV show distinct target site preferences

17 March 2017

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LEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral preintegration complexes

17 March 2017

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LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells

17 March 2017

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HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells

17 March 2017

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Spatial and temporal dynamics of two alternatively spliced regulatory factors, lens epithelium-derived growth factor (ledgf/p75) and p52, in the nucleus

17 March 2017

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DNA topoisomerases: structure, function, and mechanism

17 March 2017

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Immunohistochemical analyses of DNA topoisomerase II isoforms in developing rat cerebellum

17 March 2017

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Autoantibodies to DFS 70 kd/transcription coactivator p75 in atopic dermatitis and other conditions

17 March 2017

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17 March 2017

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Isolation of cDNAs encoding novel transcription coactivators p52 and p75 reveals an alternate regulatory mechanism of transcriptional activation

17 March 2017

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17 March 2017

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HIV-1 integration in the human genome favors active genes and local hotspots

7 April 2017

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7 April 2017

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The Dnmt3a PWWP domain reads histone 3 lysine 36 trimethylation and guides DNA methylation

9 May 2017

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High-resolution profiling of the LEDGF/p75 chromatin interaction in the ENCODE region

29 September 2017

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Implication of serine residues 271, 273, and 275 in the human immunodeficiency virus type 1 cofactor activity of lens epithelium-derived growth factor/p75.

29 September 2017

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Regulation of Set9-mediated H4K20 methylation by a PWWP domain protein

29 September 2017

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Lens epithelium-derived growth factor/p75 interacts with the transposase-derived DDE domain of PogZ.

29 September 2017

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Identification and characterization of PWWP domain residues critical for LEDGF/p75 chromatin binding and human immunodeficiency virus type 1 infectivity.

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130267

Menin critically links MLL proteins with LEDGF on cancer-associated target genes

29 September 2017

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Role of PSIP1/LEDGF/p75 in lentiviral infectivity and integration targeting

29 September 2017

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29 September 2017

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Transcription elongation through a chromatin template

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130267

Identification and characterization of the chromatin-binding domains of the HIV-1 integrase interactor LEDGF/p75.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130267

Transcriptional co-activator p75 binds and tethers the Myc-interacting protein JPO2 to chromatin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130267

A role for LEDGF/p75 in targeting HIV DNA integration

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130267

Crystal structure of the [Mg2+-(chromomycin A3)2]-d(TTGGCCAA)2 complex reveals GGCC binding specificity of the drug dimer chelated by a metal ion

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130267

Autoantibodies associated with peripheral neuropathy

29 September 2017

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Identification and characterization of a nuclear scaffold protein that binds the matrix attachment region DNA.

29 September 2017

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Fluorescent labeling of nascent RNA reveals transcription by RNA polymerase II in domains scattered throughout the nucleus

29 September 2017

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Conformational and thermodynamic properties of supercoiled DNA.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130267

DNA intercalators induce specific release of HMG 14, HMG 17 and other DNA-binding proteins from chicken erythrocyte chromatin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130267

Biorecognition of supercoiled plasmid DNA isoform in lysine-affinity chromatography

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130267

Identification of the LEDGF/p75 HIV-1 integrase-interaction domain and NLS reveals NLS-independent chromatin tethering

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130267

Levels of topoisomerase II and DNA polymerase alpha are regulated independently in developing neuronal nuclei.

3 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130267

Autoimmunity to the nuclear autoantigen DFS70 (LEDGF): what exactly are the autoantibodies trying to tell us?

3 June 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKR088

Friction and torque govern the relaxation of DNA supercoils by eukaryotic topoisomerase IB.

21 January 2018

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https://api.crossref.org/works/10.1093%2FNAR%2FGKR088

The functional response of upstream DNA to dynamic supercoiling in vivo

21 January 2018

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https://api.crossref.org/works/10.1093%2FNAR%2FGKR088

Involvement of DNA topoisomerase IIbeta in neuronal differentiation

21 January 2018

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https://api.crossref.org/works/10.1093%2FNAR%2FGKR088

Fisher/Gullain–Barré overlap syndrome in advanced AIDS

21 January 2018

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https://api.crossref.org/works/10.1093%2FNAR%2FGKR088

Two mutations of basic residues within the N-terminus of HMG-1 B domain with different effects on DNA supercoiling and binding to bent DNA.

21 January 2018

1 reference

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The nuclear scaffold exhibits DNA-binding sites selective for supercoiled DNA

21 January 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/21345933

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/NAR/GKR088

1 reference

1 reference

1 reference

1 reference