The induction levels of heat shock protein 70 differentiate the vulnerabilities to mutant huntingtin among neuronal subtypes (Q28580600)

31 January 2017

title

The induction levels of heat shock protein 70 differentiate the vulnerabilities to mutant huntingtin among neuronal subtypes (English)

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31 January 2017

4

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16 May 2020

Erich Wanker

9

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2

Shigeki Marubuchi

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31 January 2017

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Reina Inagaki

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31 January 2017

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1

Kazuhiko Tagawa

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31 January 2017

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Mei-Ling Qi

3

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16 May 2020

Takuya Tamura

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Miho Murata

7

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Ichiro Kanazawa

8

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Hitoshi Okazawa

10

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language of work or name

English

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publication date

24 January 2007

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31 January 2017

published in

Journal of Neuroscience

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volume

27

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issue

4

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page(s)

868-880

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PQBP-1, a novel polyglutamine tract-binding protein, inhibits transcription activation by Brn-2 and affects cell survival

16 May 2020

cites work

1 reference

12 December 2020

Forskolin and dopamine D1 receptor activation increase huntingtin's association with endosomes in immortalized neuronal cells of striatal origin.

1 reference

12 December 2020

Analysis of the role of heat shock protein (Hsp) molecular chaperones in polyglutamine disease

1 reference

12 December 2020

Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70.

1 reference

12 December 2020

An actin-binding protein of the Sla2/Huntingtin interacting protein 1 family is a novel component of clathrin-coated pits and vesicles

1 reference

12 December 2020

Aggregation of huntingtin in yeast varies with the length of the polyglutamine expansion and the expression of chaperone proteins

1 reference

12 December 2020

Effects of heat shock, heat shock protein 40 (HDJ-2), and proteasome inhibition on protein aggregation in cellular models of Huntington's disease

1 reference

12 December 2020

The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription

1 reference

12 December 2020

Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils

1 reference

12 December 2020

Amino-terminal fragments of mutant huntingtin show selective accumulation in striatal neurons and synaptic toxicity

1 reference

12 December 2020

Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity

1 reference

12 December 2020

Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription

1 reference

12 December 2020

Roles of the heat shock transcription factors in regulation of the heat shock response and beyond

1 reference

12 December 2020

Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation

1 reference

12 December 2020

Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice

1 reference

12 December 2020

HIP1 functions in clathrin-mediated endocytosis through binding to clathrin and adaptor protein 2

1 reference

12 December 2020

Hsp70 interactions with the p53 tumour suppressor protein

1 reference

12 December 2020

The huntingtin interacting protein HIP1 is a clathrin and alpha-adaptin-binding protein involved in receptor-mediated endocytosis

1 reference

12 December 2020

Polyglutamine expansions cause decreased CRE-mediated transcription and early gene expression changes prior to cell death in an inducible cell model of Huntington's disease

1 reference

12 December 2020

Huntingtin interacting protein 1 Is a clathrin coat binding protein required for differentiation of late spermatogenic progenitors

1 reference

12 December 2020

Chaperone suppression of cellular toxicity of huntingtin is independent of polyglutamine aggregation

1 reference

12 December 2020

Ultrastructure of nuclear aggregates formed by expressing an expanded polyglutamine

1 reference

12 December 2020

Toward cell specificity in SCA1

1 reference

12 December 2020

Interaction between mutant ataxin-1 and PQBP-1 affects transcription and cell death

1 reference

12 December 2020

The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt.

1 reference

12 December 2020

Dysregulation of gene expression in the R6/2 model of polyglutamine disease: parallel changes in muscle and brain

1 reference

12 December 2020

Polyglutamine and transcription: gene expression changes shared by DRPLA and Huntington's disease mouse models reveal context-independent effects

1 reference

12 December 2020

Increased huntingtin protein length reduces the number of polyglutamine-induced gene expression changes in mouse models of Huntington's disease

1 reference

12 December 2020

Early transcriptional profiles in huntingtin-inducible striatal cells by microarray analyses

1 reference

12 December 2020

Heat shock protein 70 chaperone overexpression ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model by reducing nuclear-localized mutant androgen receptor protein

1 reference

12 December 2020

Escape from Cbl-mediated downregulation: a recurrent theme for oncogenic deregulation of receptor tyrosine kinases

1 reference

12 December 2020

Polyglutamine diseases: a transcription disorder?

1 reference

12 December 2020

Histone deacetylase activity is retained in primary neurons expressing mutant huntingtin protein

1 reference

12 December 2020

Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice

1 reference

12 December 2020

General transcriptional repression by polyglutamine disease proteins is not directly linked to the presence of inclusion bodies

1 reference

12 December 2020

The serum- and glucocorticoid-induced kinase SGK inhibits mutant huntingtin-induced toxicity by phosphorylating serine 421 of huntingtin.

1 reference

12 December 2020

RoXaN, a novel cellular protein containing TPR, LD, and zinc finger motifs, forms a ternary complex with eukaryotic initiation factor 4G and rotavirus NSP3

1 reference

12 December 2020

Distinct aggregation and cell death patterns among different types of primary neurons induced by mutant huntingtin protein

1 reference

12 December 2020

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

1 reference

12 December 2020

Huntingtin interacting protein 1 (HIP1) regulates clathrin assembly through direct binding to the regulatory region of the clathrin light chain

1 reference

12 December 2020

Hsp70 and Hsp40 attenuate formation of spherical and annular polyglutamine oligomers by partitioning monomer

1 reference

12 December 2020

Huntingtin phosphorylation on serine 421 is significantly reduced in the striatum and by polyglutamine expansion in vivo

1 reference

12 December 2020

Akt is altered in an animal model of Huntington's disease and in patients

1 reference

12 December 2020

Gene expression in Huntington's disease skeletal muscle: a potential biomarker

1 reference

12 December 2020

Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease

1 reference

12 December 2020

p53 mediates cellular dysfunction and behavioral abnormalities in Huntington's disease

1 reference

12 December 2020

p53 tumor suppressor protein regulates the levels of huntingtin gene expression

1 reference

12 December 2020

Inhibition of calcineurin by FK506 protects against polyglutamine-huntingtin toxicity through an increase of huntingtin phosphorylation at S421.

1 reference

12 December 2020

Transcriptional repression induces a slowly progressive atypical neuronal death associated with changes of YAP isoforms and p73

1 reference

12 December 2020

Regional and cellular gene expression changes in human Huntington's disease brain

1 reference

12 December 2020

Progressive disruption of cellular protein folding in models of polyglutamine diseases.

1 reference

12 December 2020

The oct3 gene, a gene for an embryonic transcription factor, is controlled by a retinoic acid repressible enhancer

1 reference

12 December 2020

A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells

1 reference

12 December 2020

E1a transactivation of the human HSP70 promoter is mediated through the basal transcriptional complex

1 reference

12 December 2020

The E1A 13S product of adenovirus 5 activates transcription of the cellular human HSP70 gene

1 reference

12 December 2020

Cell cycle control of the human HSP70 gene: implications for the role of a cellular E1A-like function

1 reference

12 December 2020

Regulation of the human hsp70 promoter by p53

1 reference

12 December 2020

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

1 reference

12 December 2020

Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo

1 reference

12 December 2020

The cerebellar leucine-rich acidic nuclear protein interacts with ataxin-1

1 reference

12 December 2020

Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.

1 reference

12 December 2020

10.1523/JNEUROSCI.4522-06.2007

Identifiers

DOI

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672912&resulttype=core&format=json

16 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672912&resulttype=core&format=json

16 May 2020

2 references

31 January 2017