Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme (Q28582802)

GOA release 2020-03-11

amyloid-beta clearance

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GOA release 2020-03-11

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K. Vekrellis

1

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31 January 2017

Z. Ye

2

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31 January 2017

W. Q. Qiu

3

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31 January 2017

D. Walsh

4

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31 January 2017

D. Hartley

5

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31 January 2017

V. Chesneau

6

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31 January 2017

M. R. Rosner

7

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31 January 2017

D. J. Selkoe

Inducible expression and cellular localization of insulin-degrading enzyme in a stably transfected cell line

8

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31 January 2017

language of work or name

English

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publication date

1 March 2000

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31 January 2017

Journal of Neuroscience

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31 January 2017

20

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31 January 2017

1657–1665

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31 January 2017

5

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31 January 2017

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12 December 2020

Identification of zinc ligands of the insulin-degrading enzyme.

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12 December 2020

Degradation of insulin by isolated mouse pancreatic acini. Evidence for cell surface protease activity

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12 December 2020

Affinity purification of insulin-degrading enzyme and its endogenous inhibitor from rat liver

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12 December 2020

Secretion of peptides and proteins lacking hydrophobic signal sequences: the role of adenosine triphosphate-driven membrane translocators

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12 December 2020

Functional analysis of conserved residues in the active site of insulin-degrading enzyme.

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12 December 2020

Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease

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12 December 2020

Identification of insulin-degrading enzyme on the surface of cultured human lymphocytes, rat hepatoma cells, and primary cultures of rat hepatocytes

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12 December 2020

Partial purification and characterization of insulin protease and its intracellular inhibitor from rat liver

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12 December 2020

Degradation of amyloid beta-protein by a metalloprotease secreted by microglia and other neural and non-neural cells

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12 December 2020

Brain insulin and insulin receptors in aging and sporadic Alzheimer's disease.

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12 December 2020

Insulin-degrading enzyme in the Alzheimer's disease brain: prominent localization in neurons and senile plaques.

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12 December 2020

Covalent linkage of 125I-insulin to a cytosolic insulin-degrading enzyme.

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12 December 2020

Preferential adsorption, internalization and resistance to degradation of the major isoform of the Alzheimer's amyloid peptide, A beta 1-42, in differentiated PC12 cells

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12 December 2020

Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease: relationship to severity of dementia and apolipoprotein E genotype.

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12 December 2020

Insulin-degrading enzyme

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12 December 2020

Glutamate receptor-induced 45Ca2+ accumulation in cortical cell culture correlates with subsequent neuronal degeneration.

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12 December 2020

The rat insulin-degrading enzyme. Molecular cloning and characterization of tissue-specific transcripts.

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12 December 2020

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

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12 December 2020

Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation

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12 December 2020

Translating cell biology into therapeutic advances in Alzheimer's disease

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12 December 2020

Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme

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12 December 2020

Proteolytic degradation of Alzheimer's disease amyloid beta-peptide by a metalloproteinase from microglia cells.

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12 December 2020

Degradation of the cleaved leader peptide of thiolase by a peroxisomal proteinase

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12 December 2020

Insulin Degradation by Liver Cell Membranes*

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12 December 2020

Aggregation of secreted amyloid beta-protein into sodium dodecyl sulfate-stable oligomers in cell culture

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12 December 2020

Insulin-degrading enzyme does not require peroxisomal localization for insulin degradation

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12 December 2020

Metalloendopeptidase EC 3.4.24.15 is necessary for Alzheimer's amyloid-beta peptide degradation

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12 December 2020

Overexpression of insulin degrading enzyme: cellular localization and effects on insulin signaling

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12 December 2020

An insulin epidermal growth factor-binding protein from Drosophila has insulin-degrading activity

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12 December 2020

Insulin and cognitive function in an elderly population. The Rotterdam Study.

1 reference

12 December 2020

The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease

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12 December 2020

Oligomerization of endogenous and synthetic amyloid beta-protein at nanomolar levels in cell culture and stabilization of monomer by Congo red.

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12 December 2020

Degradation of Alzheimer's beta-amyloid protein by human cathepsin D.

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12 December 2020

Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments.

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12 December 2020

Internalization and resistance to degradation of Alzheimer's A beta 1-42 at nanomolar concentrations in THP-1 human monocytic cell line

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12 December 2020

Insulin degradation: mechanisms, products, and significance

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12 December 2020

Association of insulin-degrading enzyme with a 70 kDa cytosolic protein in hepatoma cells

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12 December 2020

Natural regulatory mechanisms of insulin degradation by insulin degrading enzyme

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12 December 2020

10.1016/S0197-4580(00)82319-2

Identifiers

DOI

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Consolidated OpenCitations Corpus – April 2017

4806054

4806054

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Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

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