A small molecule binding HMGB1 and HMGB2 inhibits microglia-mediated neuroinflammation (Q28585972)

GOA release 2020-03-11

Jongmin Park

5

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author name string

Sanghee Lee

1

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31 January 2017

Youngpyo Nam

2

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31 January 2017

Ja Young Koo

3

1 reference

31 January 2017

Donghyun Lim

4

1 reference

31 January 2017

Jiyeon Ock

6

1 reference

31 January 2017

Jaehong Kim

7

1 reference

31 January 2017

Kyoungho Suk

8

1 reference

31 January 2017

Seung Bum Park

Microglia and neuroinflammation: a pathological perspective

9

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31 January 2017

1 December 2014

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31 January 2017

Nature Chemical Biology

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31 January 2017

10

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31 January 2017

12

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31 January 2017

1055–1060

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31 January 2017

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The nuclear protein HMGB1 is secreted by monocytes via a non-classical, vesicle-mediated secretory pathway

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Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

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Masquerader: high mobility group box-1 and cancer

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Microglia-mediated neurotoxicity: uncovering the molecular mechanisms

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Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism

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HMGB proteins: interactions with DNA and chromatin

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High-mobility group box 1 (HMGB1) protein: friend and foe.

21 January 2018

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IFN-gamma induces high mobility group box 1 protein release partly through a TNF-dependent mechanism

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High mobility group proteins and their post-translational modifications

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Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion

21 January 2018

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Nucleocytoplasmic shuttling of HMGB1 is regulated by phosphorylation that redirects it toward secretion

21 January 2018

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Neuroinflammation: a potential therapeutic target

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Reversing established sepsis with antagonists of endogenous high-mobility group box 1.

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Inflammation-promoting activity of HMGB1 on human microvascular endothelial cells

21 January 2018

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Glycyrrhizin binds to high-mobility group box 1 protein and inhibits its cytokine activities

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Successful treatment of collagen-induced arthritis in mice and rats by targeting extracellular high mobility group box chromosomal protein 1 activity

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PubMed

https://pubmed.ncbi.nlm.nih.gov/25306442

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Phenotypic screening, take two

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1669