How were new medicines discovered? (Q29616641)

Europe PubMed Central

title

How were new medicines discovered? (English)

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30 April 2017

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Swinney DC

1

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30 April 2017

Anthony J

series ordinal

2

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21701501

30 April 2017

language of work or name

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30 April 2017

publication date

24 June 2011

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Nature Reviews Drug Discovery

30 April 2017

published in

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30 April 2017

volume

10

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30 April 2017

issue

7

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30 April 2017

page(s)

507-19

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Lessons from 60 years of pharmaceutical innovation

30 April 2017

cites work

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How to improve R&D productivity: the pharmaceutical industry's grand challenge

31 March 2020

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31 March 2020

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Drugs, their targets and the nature and number of drug targets

31 March 2020

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How many drug targets are there?

31 March 2020

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Systems and integrative biology as alternative guises for pharmacology: prime time for an iPharm concept?

31 March 2020

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Rethinking target discovery in polygenic diseases.

31 March 2020

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Functional Selectivity and Classical Concepts of Quantitative Pharmacology

31 March 2020

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Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery

31 March 2020

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Biochemical mechanisms of drug action: what does it take for success?

31 March 2020

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Biochemical mechanisms of New Molecular Entities (NMEs) approved by United States FDA during 2001-2004: mechanisms leading to optimal efficacy and safety

31 March 2020

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The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP

31 March 2020

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Molecular basis of agonism and antagonism in the oestrogen receptor

31 March 2020

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The mechanism of the effect of aspirin on human platelets. I. Acetylation of a particulate fraction protein

31 March 2020

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Drug-target residence time and its implications for lead optimization

31 March 2020

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Residence time of receptor-ligand complexes and its effect on biological function

31 March 2020

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Drug-target residence time: critical information for lead optimization.

31 March 2020

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Strategies for discovering and derisking covalent, irreversible enzyme inhibitors

31 March 2020

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Paradigm shift in neuroprotection by NMDA receptor blockade: Memantine and beyond

31 March 2020

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Pathologically activated therapeutics for neuroprotection

31 March 2020

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Allosteric receptors: from electric organ to cognition

31 March 2020

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Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

31 March 2020

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Using lidocaine and benzocaine to link sodium channel molecular conformations to state-dependent antiarrhythmic drug affinity

31 March 2020

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The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioning

31 March 2020

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Misconceptions about calcimimetics

31 March 2020

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Hypocholesterolemic activity of a novel inhibitor of cholesterol absorption, SCH 48461

31 March 2020

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A selective N-type calcium channel antagonist protects against neuronal loss after global cerebral ischemia

31 March 2020

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Natural products as sources of new drugs over the last 25 years

31 March 2020

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Therapeutic strategies based on glucagon-like peptide 1.

31 March 2020

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Rational design of potent sialidase-based inhibitors of influenza virus replication

31 March 2020

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Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini. I. Producing organism, fermentation, isolation and biological activity

31 March 2020

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New thrombopoietic growth factors

31 March 2020

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New therapeutics that antagonize endothelin: promises and frustrations

31 March 2020

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Structure-based design of aliskiren, a novel orally effective renin inhibitor

31 March 2020

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Integrase inhibitors to treat HIV/AIDS.

31 March 2020

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HIV-1 integrase inhibitors that compete with the target DNA substrate define a unique strand transfer conformation for integrase

31 March 2020

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Studies leading to the identification of ZD1839 (IRESSA): an orally active, selective epidermal growth factor receptor tyrosine kinase inhibitor targeted to the treatment of cancer

31 March 2020

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Protein therapeutics: a summary and pharmacological classification

31 March 2020

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Discovery and development of sorafenib: a multikinase inhibitor for treating cancer.

31 March 2020

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The human estrogen receptor-alpha is a ubiquitinated protein whose stability is affected differentially by agonists, antagonists, and selective estrogen receptor modulators

31 March 2020

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Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer

31 March 2020

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Glivec (STI571, imatinib), a rationally developed, targeted anticancer drug

31 March 2020

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Conserved Binding Mode of Human β 2 Adrenergic Receptor Inverse Agonists and Antagonist Revealed by X-ray Crystallography

31 March 2020

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Cell signaling by receptor tyrosine kinases

31 March 2020

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Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

31 March 2020

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Role of induced fit in enzyme specificity: a molecular forward/reverse switch

31 March 2020

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Vigilance and validation: Keys to success in RNAi screening

31 March 2020

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Transcript profiling and RNA interference as tools to identify small molecule mechanisms and therapeutic potential

31 March 2020

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Impact of high-throughput screening in biomedical research

31 March 2020

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Phenotypic screening strategies for neurodegenerative diseases: a pathway to discover novel drug candidates and potential disease targets or mechanisms

31 March 2020

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The beautiful cell: high-content screening in drug discovery

31 March 2020

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The odyssey of marine pharmaceuticals: a current pipeline perspective.

31 March 2020

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The biological activity of human CD20 monoclonal antibodies is linked to unique epitopes on CD20.

31 March 2020

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Biochemical characterization of desloratadine, a potent antagonist of the human histamine H(1) receptor

31 March 2020

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Tiotropium (Spiriva): mechanistical considerations and clinical profile in obstructive lung disease

31 March 2020

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Long-lasting angiotensin type 1 receptor binding and protection by candesartan: comparison with other biphenyl-tetrazole sartans

31 March 2020

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Comparative pharmacodynamics and pharmacokinetics of candesartan and losartan in man

31 March 2020

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Raloxifene: magic bullet for heart and bone?

31 March 2020

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Competitiveness in follow-on drug R&D: a race or imitation?

31 March 2020

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Probing the links between in vitro potency, ADMET and physicochemical parameters.

31 March 2020

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31 March 2020

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Inhibition of the immune response by rapamycin, a new antifungal antibiotic

31 March 2020

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In vitro antifungal activities and in vivo efficacies of 1,3-beta-D-glucan synthesis inhibitors L-671,329, L-646,991, tetrahydroechinocandin B, and L-687,781, a papulacandin

31 March 2020

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Synthesis of a novel series of tricyclic indan derivatives as melatonin receptor agonists

31 March 2020

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Aripiprazole, a novel antipsychotic, is a high-affinity partial agonist at human dopamine D2 receptors

31 March 2020

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Dopamine receptor agonists, partial agonists and psychostimulant addiction

31 March 2020

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Varenicline: an alpha4beta2 nicotinic receptor partial agonist for smoking cessation

31 March 2020

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Nitazoxanide, a broad-spectrum thiazolide anti-infective agent for the treatment of gastrointestinal infections

31 March 2020

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Nitazoxanide in the treatment of Taenia saginata and Hymenolepis nana infections

31 March 2020

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Catching up on schizophrenia: natural history and neurobiology

31 March 2020

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7-[3-(4-[2,3-Dimethylphenyl]piperazinyl)propoxy]-2(1H)-quinolinone (OPC-4392), a presynaptic dopamine autoreceptor agonist and postsynaptic D2 receptor antagonist.

31 March 2020

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Novel antipsychotic agents with dopamine autoreceptor agonist properties: synthesis and pharmacology of 7-[4-(4-phenyl-1-piperazinyl)butoxy]-3,4-dihydro-2(1H)-quinolinone derivatives.

31 March 2020

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Epigenetics in human disease and prospects for epigenetic therapy

31 March 2020

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Echinocandin inhibition of 1,3-β-D-glucan synthase from Candida albicans

31 March 2020

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Studies on 2-oxoquinoline derivatives as blood platelet aggregation inhibitors. I. Alkyl 4-(2-oxo-1,2,3,4-tetrahydro-6-quinolyloxy)butyrates and related compounds

31 March 2020

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Development of daptomycin for gram-positive infections

31 March 2020

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THE INACTIVATION OF THE VIRUS OF EPIDEMIC INFLUENZA BY SOAPS.

31 March 2020

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Inactivation of Lipid-Containing Viruses by Long-Chain Alcohols

31 March 2020

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Extreme Sensitivity of Enveloped Viruses, Including Herpes Simplex, to Long-Chain Unsaturated Monoglycerides and Alcohols

31 March 2020

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Antiviral activity of 1-docosanol, an inhibitor of lipid-enveloped viruses including herpes simplex

31 March 2020

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FRAP reveals that mobility of oestrogen receptor-alpha is ligand- and proteasome-dependent

31 March 2020

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ucb L059, a novel anti-convulsant drug: pharmacological profile in animals

31 March 2020

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Mechanism of action of the oxazolidinone antibacterial agents

31 March 2020

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SPI-0211 activates T84 cell chloride transport and recombinant human ClC-2 chloride currents

31 March 2020

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Basolateral localization of native ClC-2 chloride channels in absorptive intestinal epithelial cells and basolateral sorting encoded by a CBS-2 domain di-leucine motif.

31 March 2020

1 reference

Memantine is a clinically well tolerated N-methyl-D-aspartate (NMDA) receptor antagonist--a review of preclinical data

31 March 2020

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THE ADAMANTYL GROUP IN MEDICINAL AGENTS. I. HYPOGLYCEMIC N-ARYLSULFONYL-N' -ADAMANTYLUREAS

31 March 2020

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Memantine is a potent blocker of N-methyl-D-aspartate (NMDA) receptor channels

31 March 2020

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Substrate reduction therapy: miglustat as a remedy for symptomatic patients with Gaucher disease type 1.

31 March 2020

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N-acylphenylalanines and related compounds. A new class of oral hypoglycemic agents

31 March 2020

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N-(cyclohexylcarbonyl)-D-phenylalanines and related compounds. A new class of oral hypoglycemic agents. 2

31 March 2020

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Mechanisms for T-cell selective cytotoxicity of arabinosylguanine

31 March 2020

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31 March 2020

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Interaction of (4-hydroxyphenyl)pyruvate dioxygenase with the specific inhibitor 2-[2-nitro-4-(trifluoromethyl)benzoyl]-1,3-cyclohexanedione

31 March 2020

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Structure of the ferrous form of (4-hydroxyphenyl)pyruvate dioxygenase from Streptomyces avermitilis in complex with the therapeutic herbicide, NTBC.

31 March 2020

1 reference

Ranolazine, a novel agent for chronic stable angina

31 March 2020

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Anti-ischemic effects and long-term survival during ranolazine monotherapy in patients with chronic severe angina

31 March 2020

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Effects of ranolazine with atenolol, amlodipine, or diltiazem on exercise tolerance and angina frequency in patients with severe chronic angina: a randomized controlled trial

31 March 2020

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Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties

31 March 2020

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An assessment of rufinamide as an anti-epileptic in comparison with other drugs in clinical development

31 March 2020

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Diverse mechanisms of antiepileptic drugs in the development pipeline

31 March 2020

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Green tea catechins for treatment of external genital warts

31 March 2020

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Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle

31 March 2020

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Second generation hybrid polar compounds are potent inducers of transformed cell differentiation.

31 March 2020

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Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug

31 March 2020

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Structural modification of the P2' position of 2,7-dialkyl-substituted 5(S)-amino-4(S)-hydroxy-8-phenyl-octanecarboxamides: the discovery of aliskiren, a potent nonpeptide human renin inhibitor active after once daily dosing in marmosets

31 March 2020

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Non-peptide arginine-vasopressin antagonists: the vaptans

31 March 2020

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HIV drug development: the next 25 years

31 March 2020

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Chemokine antagonists as therapeutics: focus on HIV-1.

31 March 2020

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Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity

31 March 2020

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The CCR5 receptor-based mechanism of action of 873140, a potent allosteric noncompetitive HIV entry inhibitor

31 March 2020

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Regio and stereospecific synthesis of 11 beta-substituted 19-norsteroids. Influence of 11 beta-substitution on progesterone receptor affinity - (1)

31 March 2020

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Mifepristone (RU486): a review

31 March 2020

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The X-ray Structure of RU486 Bound to the Progesterone Receptor in a Destabilized Agonistic Conformation

31 March 2020

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Inhibition of pancreatic lipase in vitro by the covalent inhibitor tetrahydrolipstatin

31 March 2020

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Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells

31 March 2020

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Discovery of raltegravir, a potent, selective orally bioavailable HIV-integrase inhibitor for the treatment of HIV-AIDS infection

31 March 2020

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Fresh from the pipeline: Ramelteon.

31 March 2020

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The biology of incretin hormones

31 March 2020

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31 March 2020

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Innovations and challenges in renal cancer: consensus statement from the first international conference

31 March 2020

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Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors

31 March 2020

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Strategies in the design of antiviral drugs

31 March 2020

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A homotaurine derivative reduces the voluntary intake of ethanol by rats: are cerebral GABA receptors involved?

31 March 2020

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Photodynamic therapy with endogenous protoporphyrin IX: basic principles and present clinical experience

31 March 2020

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Structure-activity relationship in heparin: a synthetic pentasaccharide with high affinity for antithrombin III and eliciting high anti-factor Xa activity

31 March 2020

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Heparin and low-molecular-weight heparin: mechanisms of action, pharmacokinetics, dosing, monitoring, efficacy, and safety

31 March 2020

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The metabolic and molecular bases of tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency

31 March 2020

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Tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency

31 March 2020

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Tetrahydrobiopterin as an alternative treatment for mild phenylketonuria

31 March 2020

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Verteporfin: a milestone in opthalmology and photodynamic therapy

31 March 2020

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Neurokinin 1 receptor antagonists--current prospects

31 March 2020

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12 December 2020

Designing transient binding drugs: a new concept for drug discovery

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12 December 2020

Signaling-inactive epidermal growth factor receptor/ligand complexes in intact carcinoma cells by quinazoline tyrosine kinase inhibitors.

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12 December 2020

N-butyldeoxynojirimycin is a novel inhibitor of glycolipid biosynthesis.

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12 December 2020

7-(4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyloxy)-3,4-dihydro-2(1H)-quinolinone (OPC-14597), a new putative antipsychotic drug with both presynaptic dopamine autoreceptor agonistic activity and postsynaptic D2 receptor antagonistic activity.

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12 December 2020

Immunopharmacological studies on TBX, a new antiallergic drug (1). Inhibitory effects on passive cutaneous anaphylaxis in rats and guinea pigs

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12 December 2020

3-Sulfamoylmethyl-1,2-benzisoxazole, a new type of anticonvulsant drug. Pharmacological profile

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12 December 2020

From toxicological problem to therapeutic use: the discovery of the mode of action of 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione (NTBC), its toxicology and development as a drug

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12 December 2020

Preliminary studies on a more effective phototoxic agent than hematoporphyrin

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12 December 2020

Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting beta-cells.

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12 December 2020

Molecular mechanisms of local anesthesia: a review

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12 December 2020

Purine nucleoside antimetabolites in development for the treatment of cancer.

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12 December 2020

Effects of the novel antipsychotic agent 7-(4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butyloxy)-3,4-dihydro -2(1H)-quinolinone (OPC-14597) on prolactin release from the rat anterior pituitary gland

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12 December 2020

A potent specific pure antiestrogen with clinical potential

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12 December 2020

In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship.

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12 December 2020

Experimental Porphyric Neuropathy: A Preliminary Report

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12 December 2020

Pancreatic beta-cell K(ATP) channel activity and membrane-binding studies with nateglinide: A comparison with sulfonylureas and repaglinide

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12 December 2020

2-Amino-6-methoxypurine arabinoside: an agent for T-cell malignancies

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12 December 2020

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21701501

Identifiers

2 references

30 April 2017

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

298520

1047667098

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298520

1 reference

Consolidated OpenCitations Corpus – April 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21701501

2 references

30 April 2017

Consolidated OpenCitations Corpus – April 2017