Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis (Q28591211)

31 January 2017

title

Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis (English)

1 reference

Hepatic nuclear factor 4, alpha

31 January 2017

main subject

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GOA release 2020-03-11

author name string

G. P. Hayhurst

1

1 reference

31 January 2017

Y. H. Lee

2

1 reference

31 January 2017

G. Lambert

3

1 reference

31 January 2017

J. M. Ward

4

1 reference

31 January 2017

F. J. Gonzalez

5

1 reference

31 January 2017

language of work or name

English

0 references

publication date

1 February 2001

1 reference

Molecular and Cellular Biology

31 January 2017

published in

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31 January 2017

volume

21

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31 January 2017

issue

4

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31 January 2017

page(s)

1393–1403

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Regulation of the liver fatty acid-binding protein gene by hepatocyte nuclear factor 1alpha (HNF1alpha). Alterations in fatty acid homeostasis in HNF1alpha-deficient mice

31 January 2017

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Functional association between CBP and HNF4 in trans-activation

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17 March 2017

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17 March 2017

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Antagonism between apolipoprotein AI regulatory protein 1, Ear3/COUP-TF, and hepatocyte nuclear factor 4 modulates apolipoprotein CIII gene expression in liver and intestinal cells

17 March 2017

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29 September 2017

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29 September 2017

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Mammalian hepatocyte differentiation requires the transcription factor HNF-4alpha.

29 September 2017

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HNF4 and COUP-TFII interact to modulate transcription of the cholesterol 7alpha-hydroxylase gene (CYP7A1).

29 September 2017

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Modulation of transcriptional activation and coactivator interaction by a splicing variation in the F domain of nuclear receptor hepatocyte nuclear factor 4alpha1.

29 September 2017

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Normal growth and development in the absence of hepatic insulin-like growth factor I

29 September 2017

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Analysis of the role of microsomal triglyceride transfer protein in the liver of tissue-specific knockout mice

29 September 2017

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Cooperative binding of upstream stimulatory factor and hepatic nuclear factor 4 drives the transcription of the human apolipoprotein A-II gene

29 September 2017

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SRC-1 and GRIP1 coactivate transcription with hepatocyte nuclear factor 4.

29 September 2017

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Transcriptional activation of the cholesterol 7alpha-hydroxylase gene (CYP7A) by nuclear hormone receptors

29 September 2017

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Transactivation of the human apolipoprotein CII promoter by orphan and ligand-dependent nuclear receptors. The regulatory element CIIC is a thyroid hormone response element.

29 September 2017

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Functional interactions between nuclear receptors recognizing a common sequence element, the direct repeat motif spaced by one nucleotide (DR-1).

29 September 2017

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The hepatocyte nuclear factor 4 (HNF-4) represses the mitochondrial HMG-CoA synthase gene

29 September 2017

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Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver

29 September 2017

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29 September 2017

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Protein kinase A-dependent phosphorylation modulates DNA-binding activity of hepatocyte nuclear factor 4.

29 September 2017

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Hepatocyte nuclear factor 4 expression overcomes repression of the hepatic phenotype in dedifferentiated hepatoma cells

29 September 2017

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Transcriptional control of a nuclear gene encoding a mitochondrial fatty acid oxidation enzyme in transgenic mice: role for nuclear receptors in cardiac and brown adipose expression

29 September 2017

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Control of apolipoprotein AI gene expression through synergistic interactions between hepatocyte nuclear factors 3 and 4.

29 September 2017

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TFIIB-directed transcriptional activation by the orphan nuclear receptor hepatocyte nuclear factor 4.

29 September 2017

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Liver-enriched transcription factors and hepatocyte differentiation.

29 September 2017

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The expression pattern of a Drosophila homolog to the mouse transcription factor HNF-4 suggests a determinative role in gut formation

29 September 2017

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Expression of the L-type pyruvate kinase gene and the hepatocyte nuclear factor 4 transcription factor in exocrine and endocrine pancreas

29 September 2017

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A pleiotropic element in the medium-chain acyl coenzyme A dehydrogenase gene promoter mediates transcriptional regulation by multiple nuclear receptor transcription factors and defines novel receptor-DNA binding motifs

29 September 2017

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Transcriptional regulation of the apolipoprotein A-IV gene involves synergism between a proximal orphan receptor response element and a distant enhancer located in the upstream promoter region of the apolipoprotein C-III gene

29 September 2017

1 reference

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Structure of the Hepatic Control Region of the Human Apolipoprotein E/C-I Gene Locus

29 September 2017

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Fibrates increase human apolipoprotein A-II expression through activation of the peroxisome proliferator-activated receptor

29 September 2017

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Dietary influences on serum lipids and lipoproteins

29 September 2017

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A transcriptional hierarchy involved in mammalian cell-type specification

29 September 2017

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Transcriptional regulation of human apolipoprotein genes ApoB, ApoCIII, and ApoAII by members of the steroid hormone receptor superfamily HNF-4, ARP-1, EAR-2, and EAR-3.

29 September 2017

1 reference

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Acetylation regulates transcription factor activity at multiple levels

29 September 2017

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A short proximal promoter and the distal hepatic control region-1 (HCR-1) contribute to the liver specificity of the human apolipoprotein C-II gene. Hepatic enhancement by HCR-1 requires two proximal hormone response elements which have different bi

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=99591

The DNA binding domain of hepatocyte nuclear factor 4 mediates cooperative, specific binding to DNA and heterodimerization with the retinoid X receptor alpha

3 June 2018

1 reference

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Orphan receptor HNF-4 and bZip protein C/EBP alpha bind to overlapping regions of the apolipoprotein B gene promoter and synergistically activate transcription

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=99591

Hepatocyte nuclear factor-4 activates medium chain acyl-CoA dehydrogenase gene transcription by interacting with a complex regulatory element.

3 June 2018

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Characterization of the mouse HNF-4 gene and its expression during mouse embryogenesis.

3 June 2018

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Effects of fenofibrate on lipids, lipoproteins, and apolipoproteins in 33 subjects with primary hypercholesterolemia.

3 June 2018

1 reference

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Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=99591

Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=99591

Expression of putative fatty acid transporter genes are regulated by peroxisome proliferator-activated receptor alpha and gamma activators in a tissue- and inducer-specific manner

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=99591

Functional domains of the nuclear receptor hepatocyte nuclear factor 4.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=99591

Transactivation of the peroxisome proliferator-activated receptor is differentially modulated by hepatocyte nuclear factor-4

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=99591

Alterations in Thyroid Status Modulate Apolipoprotein, Hepatic Triglyceride Lipase, and Low Density Lipoprotein Receptor in Rats*

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=99591

Regulation of the peroxisome proliferator-activated receptor alpha gene by glucocorticoids

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=99591

Expression of the Peroxisome Proliferator-activated Receptor Gene Is Stimulated by Stress and Follows a Diurnal Rhythm

27 November 2018

1 reference

12 December 2020

Preparation and application of immunological probes for nucleosomes

1 reference

12 December 2020

Hepatic lipase deficiency decreases the selective uptake of HDL-cholesteryl esters in vivo

1 reference

12 December 2020

CLA-1/SR-BI Is Expressed in Atherosclerotic Lesion Macrophages and Regulated by Activators of Peroxisome Proliferator-Activated Receptors

1 reference

12 December 2020

Analysis of hypersensitive sites in chromatin

1 reference

12 December 2020

The apolipoprotein A-I/C-III/A-IV gene cluster: ApoC-III and ApoA-IV expression is regulated by two common enhancers

1 reference

12 December 2020

Fatty acyl-CoA thioesters are ligands of hepatic nuclear factor-4α

1 reference

12 December 2020

Liver-specific inactivation of the abetalipoproteinemia gene completely abrogates very low density lipoprotein/low density lipoprotein production in a viable conditional knockout mouse

1 reference

12 December 2020

10.1128/MCB.21.4.1393-1403.2001

Identifiers

DOI

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