Cathepsin S inhibitor prevents autoantigen presentation and autoimmunity (Q28591251)

31 January 2017

title

Cathepsin S inhibitor prevents autoantigen presentation and autoimmunity (English)

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31 January 2017

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GOA release 2020-03-11

Mucin 19

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GOA release 2020-03-11

author name string

Kaoru Saegusa

1

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31 January 2017

Naozumi Ishimaru

2

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31 January 2017

Kumiko Yanagi

3

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31 January 2017

Rieko Arakaki

4

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31 January 2017

Kouichi Ogawa

5

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31 January 2017

Ichiro Saito

6

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31 January 2017

Nobuhiko Katunuma

7

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31 January 2017

Yoshio Hayashi

8

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31 January 2017

language of work or name

English

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publication date

1 August 2002

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Journal of Clinical Investigation

31 January 2017

published in

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31 January 2017

volume

110

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31 January 2017

issue

3

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31 January 2017

page(s)

361–369

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Severe destructive autoimmune lesions with aging in murine Sjögren's syndrome through Fas-mediated apoptosis

31 January 2017

cites work

1 reference

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Role for cathepsin F in invariant chain processing and major histocompatibility complex class II peptide loading by macrophages

17 March 2017

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Estrogen deficiency accelerates autoimmune exocrinopathy in murine Sjögren's syndrome through fas-mediated apoptosis

17 March 2017

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Cathepsin S required for normal MHC class II peptide loading and germinal center development

17 March 2017

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Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus

17 March 2017

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Identification of alpha-fodrin as a candidate autoantigen in primary Sjögren's syndrome

17 March 2017

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Increased fluid secretion after adenoviral-mediated transfer of the aquaporin-1 cDNA to irradiated rat salivary glands

17 March 2017

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Effector mechanism of experimental autoimmune sialadenitis in the mouse model for primary Sjögren's syndrome

17 March 2017

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Major histocompatibility complex class II-associated p41 invariant chain fragment is a strong inhibitor of lysosomal cathepsin L

17 March 2017

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Essential role for cathepsin S in MHC class II-associated invariant chain processing and peptide loading

17 March 2017

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Human cathepsin S: chromosomal localization, gene structure, and tissue distribution

17 March 2017

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A new animal model for primary Sjögren's syndrome in NFS/sld mutant mice

17 March 2017

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Molecular definition and sequence motifs of the 52-kD component of human SS-A/Ro autoantigen

17 March 2017

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Molecular cloning and expression of human alveolar macrophage cathepsin S, an elastinolytic cysteine protease

17 March 2017

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Bioenergetics of immune functions: fundamental and therapeutic aspects

17 March 2017

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Cathepsin S activity regulates antigen presentation and immunity

29 September 2017

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Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation

29 September 2017

1 reference

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Degradation of mouse invariant chain: roles of cathepsins S and D and the influence of major histocompatibility complex polymorphism

29 September 2017

1 reference

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Specific T cell recognition of kinetic isomers in the binding of peptide to class II major histocompatibility complex

29 September 2017

1 reference

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Early biochemical signals arise from low affinity TCR-ligand reactions at the cell-cell interface

29 September 2017

1 reference

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How MHC class II molecules acquire peptide cargo: biosynthesis and trafficking through the endocytic pathway

29 September 2017

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Diagnostic criteria and immunopathogenesis of Sjögren's syndrome: implications for therapy

29 September 2017

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MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation

29 September 2017

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Antigen presentation. Getting peptides into MHC class II molecules

29 September 2017

1 reference

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Stimulation of T cells by antigen-presenting cells is kinetically controlled by antigenic peptide binding to major histocompatibility complex class II molecules

29 September 2017

1 reference

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Sjögren's syndrome. Proposed criteria for classification

29 September 2017

1 reference

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A new mutation involving the sublingual gland in NFS/N mice. Partially arrested mucous cell differentiation

29 September 2017

1 reference

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Role for intracellular proteases in the processing and transport of class II HLA antigens

29 September 2017

1 reference

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Class II antigen expression by lacrimal epithelial cells. An updated working hypothesis for antigen presentation by epithelial cells

29 September 2017

1 reference

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Structural analysis of proteolytic products of MHC class II-invariant chain complexes generated in vivo.

29 September 2017

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Epithelial cells expressing aberrant MHC class II determinants can present antigen to cloned human T cells

3 June 2018

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Inhibition by leupeptin and antipain of the intracellular proteolysis of Ii.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151084

Cathepsin B cleavage of Ii from class II MHC alpha- and beta-chains

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151084

Formation of a nine-subunit complex by HLA class II glycoproteins and the invariant chain

3 June 2018

1 reference

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MHC class II structure, occupancy and surface expression determined by post-endoplasmic reticulum antigen binding

3 June 2018

1 reference

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Assembly and transport properties of invariant chain trimers and HLA-DR-invariant chain complexes

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151084

Inhibition of endosomal proteolytic activity by leupeptin blocks surface expression of MHC class II molecules and their conversion to SDS resistance alpha beta heterodimers in endosomes

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151084

Impaired invariant chain degradation and antigen presentation and diminished collagen-induced arthritis in cathepsin S null mice

3 June 2018

1 reference

12 December 2020

Fas ligand-mediated exocrinopathy resembling Sjögren's syndrome in mice transgenic for IL-10

1 reference

12 December 2020

Structure based development of novel specific inhibitors for cathepsin L and cathepsin S in vitro and in vivo

1 reference

12 December 2020

Autoantigen-specific CD4+CD28low T cell subset prevents autoimmune exocrinopathy in murine Sjögren's syndrome

1 reference

12 December 2020

Mechanisms of neonatal tolerance induced in an animal model for primary Sjögren's syndrome by intravenous administration of autoantigen

1 reference

12 December 2020

1 reference

12 December 2020

Induction of experimental autoallergic sialadenitis

1 reference

12 December 2020

Role of aberrant HLA-DR expression and antigen presentation in induction of endocrine autoimmunity

1 reference

12 December 2020

Expression of histocompatibility antigen HLA-DR by salivary gland epithelial cells in Sjögren's syndrome

1 reference

12 December 2020

HLA class II induction in human islet cells by interferon-γ plus tumour necrosis factor or lymphotoxin

1 reference

12 December 2020

Class II MHC antigen expression on epithelial cells of salivary glands from patients with Sjögren's syndrome

1 reference

12 December 2020

Novel epoxysuccinyl peptides. Selective inhibitors of cathepsin B, in vitro

1 reference

12 December 2020

Novel epoxysuccinyl peptides. A selective inhibitor of cathepsin B, in vivo

1 reference

12 December 2020

Participation of cathepsin B in processing of antigen presentation to MHC class II

1 reference

12 December 2020

Specific assay method for the activities of cathepsin L-type cysteine proteinases

1 reference

12 December 2020

Identifiers

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31 January 2017

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