Haploinsufficiency of Krüppel-like factor 4 promotes adenomatous polyposis coli dependent intestinal tumorigenesis (Q28592219)

31 January 2017

title

Haploinsufficiency of Krüppel-like factor 4 promotes adenomatous polyposis coli dependent intestinal tumorigenesis (English)

1 reference

Kruppel-like factor 4 (gut)

31 January 2017

0 references

1 reference

Adenomatous polyposis coli protein

GOA release 2020-03-11

1 reference

Catenin (cadherin associated protein), beta 1

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

1 reference

Amr M. Ghaleb

1

1 reference

31 January 2017

Beth B. McConnell

2

1 reference

31 January 2017

Mandayam O. Nandan

3

1 reference

31 January 2017

Jonathan P. Katz

4

1 reference

31 January 2017

Klaus H. Kaestner

5

1 reference

31 January 2017

Vincent W. Yang

6

1 reference

31 January 2017

language of work or name

English

0 references

publication date

1 August 2007

1 reference

31 January 2017

1 reference

31 January 2017

volume

67

1 reference

31 January 2017

issue

15

1 reference

31 January 2017

page(s)

7147–7154

1 reference

Mammalian SP/KLF transcription factors: bring in the family

31 January 2017

cites work

1 reference

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17 March 2017

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Downregulation and growth inhibitory effect of epithelial-type Krüppel-like transcription factor KLF4, but not KLF5, in bladder cancer

17 March 2017

1 reference

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Overexpression of Krüppel-like factor 4 in the human colon cancer cell line RKO leads to reduced tumorigenecity

17 March 2017

1 reference

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Sp1- and Krüppel-like transcription factors

17 March 2017

1 reference

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Transcriptional profiling of Krüppel-like factor 4 reveals a function in cell cycle regulation and epithelial differentiation

17 March 2017

1 reference

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Kruppel-like factor 4 mediates p53-dependent G1/S cell cycle arrest in response to DNA damage

17 March 2017

1 reference

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Krüppel-like factor 4 (gut-enriched Krüppel-like factor) inhibits cell proliferation by blocking G1/S progression of the cell cycle

17 March 2017

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17 March 2017

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Klf4 is a transcription factor required for establishing the barrier function of the skin

17 March 2017

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17 March 2017

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Identification of c-MYC as a target of the APC pathway

17 March 2017

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The gut-enriched Krüppel-like factor suppresses the activity of the CYP1A1 promoter in an Sp1-dependent fashion

17 March 2017

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Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

17 March 2017

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Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma

17 March 2017

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17 March 2017

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Identification and characterization of a gene encoding a gut-enriched Krüppel-like factor expressed during growth arrest

17 March 2017

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The tumour suppressor gene product APC blocks cell cycle progression from G0/G1 to S phase

17 March 2017

1 reference

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The Min (multiple intestinal neoplasia) mutation: its effect on gut epithelial cell differentiation and interaction with a modifier system

17 March 2017

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APC mutations occur early during colorectal tumorigenesis

17 March 2017

1 reference

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A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse

17 March 2017

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Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene

7 April 2017

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7 April 2017

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Transcriptional profiling of the cell cycle checkpoint gene krüppel-like factor 4 reveals a global inhibitory function in macromolecular biosynthesis

7 April 2017

1 reference

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Altered expression of the KLF4 in colorectal cancers

29 September 2017

1 reference

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Novel cross talk of Kruppel-like factor 4 and beta-catenin regulates normal intestinal homeostasis and tumor repression

29 September 2017

1 reference

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Emerging role of KLF4 in human gastrointestinal cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373271

Drastic down-regulation of Krüppel-like factor 4 expression is critical in human gastric cancer development and progression

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373271

Identification of Krüppel-like factor 4 as a potential tumor suppressor gene in colorectal cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373271

Requirement of Krüppel-like factor 4 in preventing entry into mitosis following DNA damage

29 September 2017

1 reference

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Beta-catenin regulation during the cell cycle: implications in G2/M and apoptosis

29 September 2017

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Down-regulation of gut-enriched Kruppel-like factor expression in esophageal cancer

29 September 2017

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Gut-enriched Krüppel-like factor regulates colonic cell growth through APC/beta-catenin pathway

29 September 2017

1 reference

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The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon.

29 September 2017

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Expression of the gut-enriched Krüppel-like factor (Krüppel-like factor 4) gene in the human colon cancer cell line RKO is dependent on CDX2.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373271

Krüppel-like factors: three fingers in many pies

29 September 2017

1 reference

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Sp1 and krüppel-like factor family of transcription factors in cell growth regulation and cancer

29 September 2017

1 reference

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The biology of the mammalian Krüppel-like family of transcription factors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373271

Role of gut-enriched Krüppel-like factor in colonic cell growth and differentiation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373271

Decreased expression of the gut-enriched Krüppel-like factor gene in intestinal adenomas of multiple intestinal neoplasia mice and in colonic adenomas of familial adenomatous polyposis patients

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373271

Expression of the gut-enriched Krüppel-like factor gene during development and intestinal tumorigenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373271

The APC gene product in normal and tumor cells

29 September 2017

1 reference

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Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373271

Proliferation, but not apoptosis, is associated with distinct beta-catenin expression patterns in non-small-cell lung carcinomas: relationship with adenomatous polyposis coli and G(1)-to S-phase cell-cycle regulators

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373271

Studies of neoplasia in the Min mouse

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373271

Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373271

Inactivation of both APC alleles in an early stage of colon adenomas in a patient with familial adenomatous polyposis (FAP).

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373271

The APC tumor suppressor controls entry into S-phase through its ability to regulate the cyclin D/RB pathway.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373271

Phosphorylation of the tumor suppressor adenomatous polyposis coli (APC) by the cyclin-dependent kinase p34.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2373271

Loss of Apc+ in intestinal adenomas from Min mice

27 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/17671182

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1158/0008-5472.CAN-07-1302

1 reference

1 reference

1 reference

1 reference