Mice deficient in Ext2 lack heparan sulfate and develop exostoses (Q28592253)

31 January 2017

title

Mice deficient in Ext2 lack heparan sulfate and develop exostoses (English)

1 reference

Exostosin glycosyltransferase 2

31 January 2017

main subject

1 reference

GOA release 2020-03-11

5

Zena Werb

0 references

author name string

Dominique Stickens

1

1 reference

31 January 2017

Beverly M. Zak

2

1 reference

31 January 2017

Nathalie Rougier

3

1 reference

31 January 2017

Jeffrey D. Esko

4

1 reference

31 January 2017

Zena Werb

5

1 reference

31 January 2017

language of work or name

English

0 references

publication date

1 November 2005

1 reference

31 January 2017

1 reference

31 January 2017

volume

132

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31 January 2017

issue

22

1 reference

31 January 2017

page(s)

5055–5068

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The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice

31 January 2017

cites work

1 reference

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Hereditary multiple exostoses and heparan sulfate polymerization

17 March 2017

1 reference

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BMP and Ihh/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiation

17 March 2017

1 reference

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The EXT1/EXT2 tumor suppressors: catalytic activities and role in heparan sulfate biosynthesis

17 March 2017

1 reference

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Disruption of gastrulation and heparan sulfate biosynthesis in EXT1-deficient mice

17 March 2017

1 reference

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Molecular basis of multiple exostoses: mutations in the EXT1 and EXT2 genes

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767329

The putative tumor suppressors EXT1 and EXT2 form a stable complex that accumulates in the Golgi apparatus and catalyzes the synthesis of heparan sulfate

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767329

Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation

17 March 2017

1 reference

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The putative tumor suppressors EXT1 and EXT2 are glycosyltransferases required for the biosynthesis of heparan sulfate

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767329

The putative tumour suppressor EXT1 alters the expression of cell-surface heparan sulfate

17 March 2017

1 reference

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Evidence that absence of Wnt-3a signaling promotes neuralization instead of paraxial mesoderm development in the mouse

17 March 2017

1 reference

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The EXT2 multiple exostoses gene defines a family of putative tumour suppressor genes

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767329

Genetic heterogeneity in families with hereditary multiple exostoses

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767329

Assignment of a second locus for multiple exostoses to the pericentromeric region of chromosome 11

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767329

A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo

17 March 2017

1 reference

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A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse

17 March 2017

1 reference

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Requirement of FGF-4 for postimplantation mouse development

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767329

The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo

17 March 2017

1 reference

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Requirement for Lim1 in head-organizer function

17 March 2017

1 reference

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Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse

17 March 2017

1 reference

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Cloning of the putative tumour suppressor gene for hereditary multiple exostoses (EXT1)

17 March 2017

1 reference

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Promotion of trophoblast stem cell proliferation by FGF4

17 March 2017

1 reference

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Order out of chaos: assembly of ligand binding sites in heparan sulfate

7 April 2017

1 reference

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Expression pattern of the mouse T gene and its role in mesoderm formation

7 April 2017

1 reference

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Functions of heparan sulfate proteoglycans in cell signaling during development

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767329

Consequences of knocking out BMP signaling in the mouse

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767329

Heparan sulfate fine structure and specificity of proteoglycan functions

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767329

FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767329

Reaching a genetic and molecular understanding of skeletal development

29 September 2017

1 reference

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Targeted disruption of fibroblast growth factor (FGF) receptor 2 suggests a role for FGF signaling in pregastrulation mammalian development

29 September 2017

1 reference

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Anterior primitive endoderm may be responsible for patterning the anterior neural plate in the mouse embryo

29 September 2017

1 reference

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A gene for hereditary multiple exostoses maps to chromosome 19p.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767329

Embryonic expression of Lim-1, the mouse homolog of Xenopus Xlim-1, suggests a role in lateral mesoderm differentiation and neurogenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767329

Hereditary multiple exostosis and chondrosarcoma: linkage to chromosome II and loss of heterozygosity for EXT-linked markers on chromosomes II and 8.

29 September 2017

1 reference

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Use of dermestid beetles for cleaning bones

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767329

Expression of the murine apolipoprotein E gene is coupled to the differentiated state of F9 embryonal carcinoma cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767329

Hereditary multiple exostoses.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767329

Location of the glucuronosyltransferase domain in the heparan sulfate copolymerase EXT1 by analysis of Chinese hamster ovary cell mutants

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767329

Does adult fracture repair recapitulate embryonic skeletal formation?

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767329

Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767329

Comparison of the expression of three highly related genes, Fgf8, Fgf17 and Fgf18, in the mouse embryo

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767329

Differential staining of cartilage and bone in whole mouse fetuses by alcian blue and alizarin red S.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767329

The murine H19 gene is activated during embryonic stem cell differentiation in vitro and at the time of implantation in the developing embryo

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767329

Cloning and developmental expression of Sna, a murine homologue of the Drosophila snail gene

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767329

Isolation of Sna, a mouse gene homologous to the Drosophila genes snail and escargot: its expression pattern suggests multiple roles during postimplantation development

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767329

Axon sorting in the optic tract requires HSPG synthesis by ext2 (dackel) and extl3 (boxer).

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767329

Ext1-dependent heparan sulfate regulates the range of Ihh signaling during endochondral ossification

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767329

Abrogation of heparan sulfate synthesis in Drosophila disrupts the Wingless, Hedgehog and Decapentaplegic signaling pathways

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767329

Distinct and collaborative roles of Drosophila EXT family proteins in morphogen signalling and gradient formation

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767329

Three Drosophila EXT genes shape morphogen gradients through synthesis of heparan sulfate proteoglycans

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767329

Essential role of glycosaminoglycans in Fgf signaling during mouse gastrulation.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767329

Interaction of FGF, Ihh/Pthlh, and BMP signaling integrates chondrocyte proliferation and hypertrophic differentiation

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767329

PTHrP and Indian hedgehog control differentiation of growth plate chondrocytes at multiple steps.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767329

Partial rescue of PTH/PTHrP receptor knockout mice by targeted expression of the Jansen transgene.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767329

FGF Signaling Regulates Mesoderm Cell Fate Specification and Morphogenetic Movement at the Primitive Streak

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767329

FGF signaling in skeletal development.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767329

Rpx: a novel anterior-restricted homeobox gene progressively activated in the prechordal plate, anterior neural plate and Rathke's pouch of the mouse embryo.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767329

Positive and negative signals from mesoderm regulate the expression of mouse Otx2 in ectoderm explants

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767329

Transgenic expression of the EXT2 gene in developing chondrocytes enhances the synthesis of heparan sulfate and bone formation in mice

27 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/16236767

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Undersulfated heparan sulfate in a Chinese hamster ovary cell mutant defective in heparan sulfate N-sulfotransferase

1 reference

https://pubmed.ncbi.nlm.nih.gov/16236767

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

EXT1 regulates chondrocyte proliferation and differentiation during endochondral bone development

1 reference

https://pubmed.ncbi.nlm.nih.gov/16236767

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

1 reference

31 January 2017

0 references

1 reference