PTH stimulates bone formation in mice deficient in Lrp5 (Q28592421)

GOA release 2020-03-11

author name string

Urszula T. Iwaniec

1

1 reference

31 January 2017

Thomas J. Wronski

2

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31 January 2017

Jeff Liu

3

1 reference

31 January 2017

Mercedes F. Rivera

4

1 reference

31 January 2017

Rosemarie R. Arzaga

5

1 reference

31 January 2017

Gwenn Hansen

6

1 reference

31 January 2017

Robert Brommage

Journal of Bone and Mineral Research

7

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31 January 2017

1 March 2007

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31 January 2017

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31 January 2017

22

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31 January 2017

3

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31 January 2017

394–402

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31 January 2017

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Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor

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1 reference

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High bone mass in mice expressing a mutant LRP5 gene

21 January 2018

1 reference

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Reduced affinity to and inhibition by DKK1 form a common mechanism by which high bone mass-associated missense mutations in LRP5 affect canonical Wnt signaling

21 January 2018

1 reference

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Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling

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1 reference

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SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor

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21 January 2018

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Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation

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Polymorphisms in the low-density lipoprotein receptor-related protein 5 (LRP5) gene are associated with variation in vertebral bone mass, vertebral bone size, and stature in whites

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1 reference

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Molecular profile of catabolic versus anabolic treatment regimens of parathyroid hormone (PTH) in rat bone: an analysis by DNA microarray

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1 reference

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Effects of parathyroid hormone on Wnt signaling pathway in bone

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Anabolic Actions of Parathyroid Hormone on Bone*

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1 reference

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Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice

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The Wnt co-receptor LRP5 is essential for skeletal mechanotransduction but not for the anabolic bone response to parathyroid hormone treatment

21 January 2018

1 reference

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Wnt signalling in osteoblasts regulates expression of the receptor activator of NFkappaB ligand and inhibits osteoclastogenesis in vitro

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1 reference

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1 reference

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Linking beta-catenin to androgen-signaling pathway

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Chronic elevation of parathyroid hormone in mice reduces expression of sclerostin by osteocytes: a novel mechanism for hormonal control of osteoblastogenesis

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1 reference

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SOST is a target gene for PTH in bone

21 January 2018

1 reference

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beta-Arrestin2 regulates the differential response of cortical and trabecular bone to intermittent PTH in female mice

21 January 2018

1 reference

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Anabolic action of parathyroid hormone is skeletal site specific at the tissue and cellular levels in mice.

21 January 2018

1 reference

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Combined treatment with a beta-blocker and intermittent PTH improves bone mass and microarchitecture in ovariectomized mice

21 January 2018

1 reference

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Human parathyroid hormone 1-34 reverses bone loss in ovariectomized mice

21 January 2018

1 reference

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Impaired bone anabolic response to parathyroid hormone in Fgf2-/- and Fgf2+/- mice.

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