Macroautophagy substrates are loaded onto MHC class II of medullary thymic epithelial cells for central tolerance (Q28593303)

GOA release 2020-03-11

author name string

Martin Aichinger

1

1 reference

31 January 2017

Chunyan Wu

2

1 reference

31 January 2017

Jelena Nedjic

3

1 reference

31 January 2017

Ludger Klein

Journal of Experimental Medicine

4

1 reference

31 January 2017

language of work or name

English

0 references

publication date

11 February 2013

1 reference

31 January 2017

1 reference

31 January 2017

210

1 reference

31 January 2017

287–300

1 reference

31 January 2017

2

1 reference

31 January 2017

Chaperone-mediated autophagy: a unique way to enter the lysosome world

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3570095

Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3570095

p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3570095

Selective degradation of mitochondria by mitophagy

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3570095

Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3570095

In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3570095

Projection of an immunological self shadow within the thymus by the aire protein

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3570095

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3570095

Mice lacking MHC class II molecules

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3570095

p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3570095

The role of autophagy during the early neonatal starvation period

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3570095

Differential processing of self-antigens by subsets of thymic stromal cells.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3570095

Autophagy in protein and organelle turnover

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3570095

Autonomous role of medullary thymic epithelial cells in central CD4(+) T cell tolerance

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3570095

Antigen presentation in the thymus for positive selection and central tolerance induction

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3570095

Autophagic compartments gain access to the MHC class II compartments in thymic epithelium.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3570095

Regulatory T cell differentiation of thymocytes does not require a dedicated antigen-presenting cell but is under T cell-intrinsic developmental control.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3570095

Macroautophagy, endogenous MHC II loading and T cell selection: the benefits of breaking the rules

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3570095

Enhancing immunity through autophagy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3570095

Endogenous presentation of a nuclear antigen on MHC class II by autophagy in the absence of CRM1-mediated nuclear export

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3570095

Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3570095

Protein turnover via autophagy: implications for metabolism

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3570095

Zoned out: functional mapping of stromal signaling microenvironments in the thymus

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3570095

Antigen-loading compartments for major histocompatibility complex class II molecules continuously receive input from autophagosomes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3570095

Autophagy in MHC class II antigen processing

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3570095

A central role for central tolerance

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3570095

Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3570095

Autophagy promotes MHC class II presentation of peptides from intracellular source proteins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3570095

Lamp-2a facilitates MHC class II presentation of cytoplasmic antigens

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3570095

Endogenous MHC class II processing of a viral nuclear antigen after autophagy.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3570095

Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3570095

Major histocompatibility complex class II-restricted presentation of a cytosolic antigen by autophagy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3570095

Positive and negative selection of T cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3570095

Vacuolar import of proteins and organelles from the cytoplasm

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3570095

CD4 T cell tolerance to human C-reactive protein, an inducible serum protein, is mediated by medullary thymic epithelium

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3570095

Excessive degradation of intracellular protein in macrophages prevents presentation in the context of major histocompatibility complex class II molecules

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3570095

Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3570095

The thymic medulla: a unique microenvironment for intercellular self-antigen transfer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3570095

Antigen compartmentation and T helper cell tolerance induction

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3570095

Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3570095

Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self.

3 June 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20122149

In vivo MHC class II presentation of cytosolic proteins revealed by rapid automated tandem mass spectrometry and functional analyses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20122149

Processing and presentation of HLA class I and II epitopes by dendritic cells after transfection with in vitro-transcribed MUC1 RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20122149

Aire regulates the transfer of antigen from mTECs to dendritic cells for induction of thymic tolerance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20122149

Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20122149

Pancreatic gene expression in rare cells of thymic medulla: evidence for functional contribution to T cell tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20122149

Sampling of complementing self-antigen pools by thymic stromal cells maximizes the scope of central T cell tolerance

21 January 2018

1 reference

12 December 2020

Mice lacking the MHC class II transactivator (CIITA) show tissue-specific impairment of MHC class II expression

1 reference

12 December 2020

CD4 T cell tolerance to nuclear proteins induced by medullary thymic epithelium

1 reference

12 December 2020

Autonomous versus dendritic cell-dependent contributions of medullary thymic epithelial cells to central tolerance

1 reference

12 December 2020

NFAT-controlled expression of GFP permits visualization and isolation of antigen-stimulated primary human T cells

1 reference

12 December 2020

Identifiers

DOI

10.1084/JEM.20122149

1 reference

601209

601209

1 reference

1 reference

1 reference