Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation (Q28594707)

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta

GOA release 2020-03-11

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GOA release 2020-03-11

2

Marc Claret

1 reference

31 January 2017

Emma Peskett

6

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Klaus Okkenhaug

object named as

Klaus Okkenhaug

4

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Bart Vanhaesebroeck

10

object named as

Bart Vanhaesebroeck

1 reference

31 January 2017

Lazaros C. Foukas

1

1 reference

31 January 2017

Wayne Pearce

3

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31 January 2017

Stephen Meek

5

1 reference

31 January 2017

Sara Sancho

7

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31 January 2017

Andrew J. H. Smith

8

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31 January 2017

Dominic J. Withers

High frequency of mutations of the PIK3CA gene in human cancers

9

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31 January 2017

language of work or name

English

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publication date

18 May 2006

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31 January 2017

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31 January 2017

441

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31 January 2017

366–370

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31 January 2017

7091

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31 January 2017

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Early embryonic lethality in mice deficient in the p110beta catalytic subunit of PI 3-kinase

21 April 2017

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Essential role of PDK1 in regulating cell size and development in mice

21 April 2017

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Intracellular signalling. Key enzyme in leptin-induced anorexia

21 April 2017

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PI 3-kinase p110beta: a new target for antithrombotic therapy

21 April 2017

1 reference

Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

21 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04694

PIK3CA is implicated as an oncogene in ovarian cancer.

21 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04694

7 January 2021

Signalling by PI3K isoforms: insights from gene-targeted mice.

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https://api.crossref.org/works/10.1038%2FNATURE04694

7 January 2021

Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinase

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04694

7 January 2021

Phosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04694

7 January 2021

Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85 alpha

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04694

7 January 2021

Biology of insulin-like growth factors in development.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04694

7 January 2021

Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04694

7 January 2021

The role of insulin receptor substrate 2 in hypothalamic and beta cell function.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04694

7 January 2021

Trophic action of leptin on hypothalamic neurons that regulate feeding

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04694

7 January 2021

Insulin signaling in health and disease

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04694

7 January 2021

Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: a key mediator of insulin-induced anorexia

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04694

7 January 2021

PI3K integrates the action of insulin and leptin on hypothalamic neurons

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04694

7 January 2021

Insulin receptor substrate proteins and neuroendocrine function

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04694

7 January 2021

Actin filaments participate in the relocalization of phosphatidylinositol3-kinase to glucose transporter-containing compartments and in the stimulation of glucose uptake in 3T3-L1 adipocytes

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04694

7 January 2021

p110beta is up-regulated during differentiation of 3T3-L1 cells and contributes to the highly insulin-responsive glucose transport activity

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04694

7 January 2021

A function for phosphatidylinositol 3-kinase beta (p85alpha-p110beta) in fibroblasts during mitogenesis: requirement for insulin- and lysophosphatidic acid-mediated signal transduction

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04694

7 January 2021

Heterodimeric phosphoinositide 3-kinase consisting of p85 and p110beta is synergistically activated by the betagamma subunits of G proteins and phosphotyrosyl peptide

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04694

7 January 2021

Specific role for p85/p110beta in GTP-binding-protein-mediated activation of Akt.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04694

7 January 2021

Insulin-like growth factors and neoplasia.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04694

7 January 2021

The survival kinases Akt and Pim as potential pharmacological targets

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04694

7 January 2021

The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04694

7 January 2021

Identifiers

DOI

10.1038/NATURE04694

1 reference

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

1969029

1011965244

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1969029

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference