Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85 alpha (Q73150469)

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1 November 2019

title

Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85 alpha (English)

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1 November 2019

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D A Fruman

1

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F Mauvais-Jarvis

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D A Pollard

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C M Yballe

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D Brazil

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R T Bronson

6

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C R Kahn

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L C Cantley

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publication date

1 November 2000

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volume

26

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page(s)

379-382

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1 November 2019

issue

3

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https://scigraph.springernature.com/pub.10.1038/81715

1 November 2019

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cites work

Signaling by distinct classes of phosphoinositide 3-kinases

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7 January 2021

Phosphoinositide kinases

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7 January 2021

Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase

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7 January 2021

Structural organization and alternative splicing of the murine phosphoinositide 3-kinase p85 alpha gene

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7 January 2021

Insulin receptor substrate 1 binds two novel splice variants of the regulatory subunit of phosphatidylinositol 3-kinase in muscle and brain

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7 January 2021

p85alpha gene generates three isoforms of regulatory subunit for phosphatidylinositol 3-kinase (PI 3-Kinase), p50alpha, p55alpha, and p85alpha, with different PI 3-kinase activity elevating responses to insulin

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7 January 2021

Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha.

1 reference

7 January 2021

Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B

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7 January 2021

Severe liver degeneration in mice lacking the IkappaB kinase 2 gene

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7 January 2021

Regulation of endocytic-transcytotic pathways and bile secretion by phosphatidylinositol 3-kinase in rats.

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7 January 2021

The role of phosphoinositide 3-kinase in taurocholate-induced trafficking of ATP-dependent canalicular transporters in rat liver

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7 January 2021

Phosphoinositide 3-kinase lipid products regulate ATP-dependent transport by sister of P-glycoprotein and multidrug resistance associated protein 2 in bile canalicular membrane vesicles

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7 January 2021

Evaluation and management of chylous ascites

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7 January 2021

An essential role of phosphatidylinositol 3-kinase in myogenic differentiation.

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7 January 2021

The conserved phosphoinositide 3-kinase pathway determines heart size in mice

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7 January 2021

Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling

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7 January 2021

Differential regulation of phosphoinositide 3-kinase adapter subunit variants by insulin in human skeletal muscle

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7 January 2021

Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse

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7 January 2021

Regulation of the p85/p110 phosphatidylinositol 3'-kinase: stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit

1 reference

7 January 2021

The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase

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7 January 2021

PI3K: downstream AKTion blocks apoptosis

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7 January 2021

Adenovirus-mediated overexpression of IRS-1 interacting domains abolishes insulin-stimulated mitogenesis without affecting glucose transport in 3T3-L1 adipocytes

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7 January 2021

Glucosamine infusion in rats rapidly impairs insulin stimulation of phosphoinositide 3-kinase but does not alter activation of Akt/protein kinase B in skeletal muscle.

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7 January 2021

Early neonatal death in mice homozygous for a null allele of the insulin receptor gene

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7 January 2021

Disruption of IRS-2 causes type 2 diabetes in mice

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7 January 2021

Membrane-targeted phosphatidylinositol 3-kinase mimics insulin actions and induces a state of cellular insulin resistance

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7 January 2021

Identifiers

DOI

10.1038/81715

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1 November 2019

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