Botulinum and tetanus neurotoxins: structure, function and therapeutic utility (Q28609172)

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7 January 2021

Sequence homology and structural analysis of the clostridial neurotoxins

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7 January 2021

Crystal structure of botulinum neurotoxin type A and implications for toxicity

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7 January 2021

Structural analysis of the catalytic and binding sites of Clostridium botulinum neurotoxin B

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7 January 2021

Structure of the receptor binding fragment HC of tetanus neurotoxin

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7 January 2021

Tyrosine-1290 of tetanus neurotoxin plays a key role in its binding to gangliosides and functional binding to neurones

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7 January 2021

Structure-based sequence alignment for the beta-trefoil subdomain of the clostridial neurotoxin family provides residue level information about the putative ganglioside binding site

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7 January 2021

The crystal structure of tetanus toxin Hc fragment complexed with a synthetic GT1b analogue suggests cross-linking between ganglioside receptors and the toxin

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7 January 2021

The structures of the H(C) fragment of tetanus toxin with carbohydrate subunit complexes provide insight into ganglioside binding

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7 January 2021

How do tetanus and botulinum toxins bind to neuronal membranes?

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7 January 2021

The high-affinity binding of Clostridium botulinum type B neurotoxin to synaptotagmin II associated with gangliosides GT1b/GD1a.

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7 January 2021

High sensitivity of mouse neuronal cells to tetanus toxin requires a GPI-anchored protein

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7 January 2021

Bacterial protein toxins penetrate cells via a four-step mechanism

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7 January 2021

The N-terminal half of the heavy chain of botulinum type A neurotoxin forms channels in planar phospholipid bilayers

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7 January 2021

Gating and permeability of ion channels produced by botulinum toxin types A and E in PC12 cell membranes

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7 January 2021

Synaptic vesicle docking and fusion

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7 January 2021

How botulinum and tetanus neurotoxins block neurotransmitter release.

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7 January 2021

Botulinum neurotoxins: from paralysis to recovery of functional neuromuscular transmission

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7 January 2021

Tetanus toxin and spinal inhibition.

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7 January 2021

Tetanus and botulinum neurotoxins: mechanism of action and therapeutic uses

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7 January 2021

C-terminal half of tetanus toxin fragment C is sufficient for neuronal binding and interaction with a putative protein receptor.

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7 January 2021

Ion-conducting channels produced by botulinum toxin in planar lipid membranes

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7 January 2021

Spectroscopic analysis of pH-induced changes in the molecular features of type A botulinum neurotoxin light chain

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7 January 2021

Tyrosine phosphorylation modulates the activity of clostridial neurotoxins

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7 January 2021

Structural stabilization of botulinum neurotoxins by tyrosine phosphorylation.

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7 January 2021

Clostridial neurotoxin-insensitive vesicular SNAREs in exocytosis and endocytosis

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7 January 2021

Proteolysis of SNAP-25 isoforms by botulinum neurotoxin types A, C, and E: domains and amino acid residues controlling the formation of enzyme-substrate complexes and cleavage

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7 January 2021

Structural determinants of the specificity for synaptic vesicle-associated membrane protein/synaptobrevin of tetanus and botulinum type B and G neurotoxins

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7 January 2021

Botulinum neurotoxin types A and E require the SNARE motif in SNAP-25 for proteolysis.

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7 January 2021

SNARE motif and neurotoxins

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7 January 2021

Cocrystal structure of synaptobrevin-II bound to botulinum neurotoxin type B at 2.0 A resolution

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7 January 2021

Structural studies on the zinc-endopeptidase light chain of tetanus neurotoxin

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7 January 2021

Role of zinc in the structure and toxic activity of botulinum neurotoxin

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7 January 2021

Role of zinc binding in type A botulinum neurotoxin light chain's toxic structure

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7 January 2021

The role of zinc binding in the biological activity of botulinum toxin

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7 January 2021

Metal substitution of tetanus neurotoxin

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7 January 2021

Site-directed mutagenesis identifies active-site residues of the light chain of botulinum neurotoxin type A.

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7 January 2021

Structural basis of the action of thermolysin and related zinc peptidases

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7 January 2021

Probing the mechanistic role of glutamate residue in the zinc-binding motif of type A botulinum neurotoxin light chain

1 reference

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7 January 2021

Expression and purification of the light chain of botulinum neurotoxin A: a single mutation abolishes its cleavage of SNAP-25 and neurotoxicity after reconstitution with the heavy chain.

1 reference

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7 January 2021

Active-site mutagenesis of tetanus neurotoxin implicates TYR-375 and GLU-271 in metalloproteolytic activity

1 reference

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7 January 2021

Arg(362) and Tyr(365) of the botulinum neurotoxin type a light chain are involved in transition state stabilization

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7 January 2021

Exocytosis requires asymmetry in the central layer of the SNARE complex

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7 January 2021

Synaptic vesicle membrane fusion complex: action of clostridial neurotoxins on assembly

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7 January 2021

The role of the synaptic protein snap-25 in the potency of botulinum neurotoxin type A.

1 reference

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7 January 2021

Clostridial toxins as therapeutic agents: benefits of nature's most toxic proteins

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7 January 2021

Uses of botulinum toxin injection in medicine today

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7 January 2021

Botulinum toxin A for axillary hyperhidrosis (excessive sweating).

1 reference

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7 January 2021

A comparative trial of botulinum toxin type A and methylprednisolone for the treatment of myofascial pain syndrome and pain from chronic muscle spasm

1 reference

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7 January 2021

Botulinum toxin type A as a migraine preventive treatment. For the BOTOX Migraine Clinical Research Group

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7 January 2021

Botulinum neurotoxin serotype C: a novel effective botulinum toxin therapy in human.

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7 January 2021

A conjugate composed of nerve growth factor coupled to a non-toxic derivative of Clostridium botulinum neurotoxin type A can inhibit neurotransmitter release in vitro

1 reference

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7 January 2021

Inhibition of vesicular secretion in both neuronal and nonneuronal cells by a retargeted endopeptidase derivative of Clostridium botulinum neurotoxin type A

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7 January 2021

Identification of the characteristics that underlie botulinum toxin potency: implications for designing novel drugs

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7 January 2021

Non-viral neuronal gene delivery mediated by the HC fragment of tetanus toxin

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7 January 2021

Delivery of recombinant tetanus-superoxide dismutase proteins to central nervous system neurons by retrograde axonal transport.

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7 January 2021

Recombinant derivatives of clostridial neurotoxins as delivery vehicles for proteins and small organic molecules

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7 January 2021

Colonisation of Clostridium in the body is restricted to hypoxic and necrotic areas of tumours.

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7 January 2021

Chemotherapeutic tumour targeting using clostridial spores

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7 January 2021