How immune peptidases change specificity: cathepsin G gained tryptic function but lost efficiency during primate evolution (Q28657738)

1

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Neil N Trivedi

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Anastasia Makarova

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Manisha Ray

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Charles S Craik

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George H Caughey

Cleavage of CXCR1 on neutrophils disables bacterial killing in cystic fibrosis lung disease

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language of work or name

English

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publication date

1 November 2010

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published in

Journal of Immunology

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volume

185

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issue

9

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page(s)

5360-8

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cites work

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Cooperation between mast cell carboxypeptidase A and the chymase mouse mast cell protease 4 in the formation and degradation of angiotensin II

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Cathepsin G activates protease-activated receptor-4 in human platelets

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Rapid conversion of angiotensin I to angiotensin II by neutrophil and mast cell proteinases

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Molecular cloning of human cathepsin G: structural similarity to mast cell and cytotoxic T lymphocyte proteinases

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Elastase and cathepsin G of human monocytes. Quantification of cellular content, release in response to stimuli, and heterogeneity in elastase-mediated proteolytic activity

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Human lysosomal cathepsin G and granzyme B share a functionally conserved broad spectrum antibacterial peptide

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Alpha 2-macroglobulin capture allows detection of mast cell chymase in serum and creates a reservoir of angiotensin II-generating activity

7 April 2017

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Cathepsin G is differentially expressed in primary human antigen-presenting cells

3 June 2018

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Guinea pig chymase is leucine-specific: a novel example of functional plasticity in the chymase/granzyme family of serine peptidases

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3 June 2018

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Mast cell and neutrophil peptidases attack an inactivation segment in hepatocyte growth factor to generate NK4-like antagonists

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Serine protease cathepsin G regulates adhesion-dependent neutrophil effector functions by modulating integrin clustering

3 June 2018

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Neutrophil serine proteinases cleave bacterial flagellin, abrogating its host response-inducing activity

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A despecialization step underlying evolution of a family of serine proteases

3 June 2018

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Albumin is a substrate of human chymase. Prediction by combinatorial peptide screening and development of a selective inhibitor based on the albumin cleavage site

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3 June 2018

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Human tryptases alpha and beta/II are functionally distinct due, in part, to a single amino acid difference in one of the surface loops that forms the substrate-binding cleft

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3 June 2018

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3 June 2018

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3 June 2018

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3 June 2018

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27 November 2018

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12 December 2020

Identification of a cathepsin G-like proteinase in the MCTC type of human mast cell.

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Cathepsin-G interferes with clearance of Pseudomonas aeruginosa from mouse lungs

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