NFAT2 inhibitor ameliorates diabetic nephropathy and podocyte injury in db/db mice (Q28661524)

2

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Wei Shi

3

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Xinling Liang

4

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Shuangxin Liu

5

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Zhiming Ye

6

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Chunping Yu

7

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Yuanhan Chen

8

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Bin Zhang

9

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Wenjian Wang

10

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Yuxiong Lai

11

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Jianchao Ma

12

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Zhuo Li

13

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Xiaofan Tan

British Journal of Pharmacology

14

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language of work or name

English

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publication date

September 2013

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published in

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volume

170

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issue

2

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page(s)

426-39

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cites work

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The calcineurin-NFAT pathway allows for urokinase receptor-mediated beta3 integrin signaling to cause podocyte injury

17 March 2017

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Genipin inhibits mitochondrial uncoupling protein 2 expression and ameliorates podocyte injury in diabetic mice

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Angiotensin II contributes to podocyte injury by increasing TRPC6 expression via an NFAT-mediated positive feedback signaling pathway.

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Calcineurin (CN) activation promotes apoptosis of glomerular podocytes both in vitro and in vivo

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The targeted podocyte

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Diabetic nephropathy -- a multifaceted target of new therapies.

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Activation of a nuclear factor of activated T-lymphocyte-3 (NFAT3) by oxidative stress in carboplatin-mediated renal apoptosis

3 June 2018

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Activation of NFAT signaling in podocytes causes glomerulosclerosis

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TRPC6 mutations associated with focal segmental glomerulosclerosis cause constitutive activation of NFAT-dependent transcription.

3 June 2018

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Epithelial-to-mesenchymal transition is a potential pathway leading to podocyte dysfunction and proteinuria

3 June 2018

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Podocyte biology in diabetic nephropathy

3 June 2018

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From the periphery of the glomerular capillary wall toward the center of disease: podocyte injury comes of age in diabetic nephropathy

3 June 2018

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WT1-interacting protein and ZO-1 translocate into podocyte nuclei after puromycin aminonucleoside treatment

3 June 2018

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The transcription factor NFAT3 mediates neuronal survival

3 June 2018

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Diabetic kidney disease in thedb/dbmouse

3 June 2018

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Diabetic Nephropathy in Type 2 Diabetes Prevention and Patient Management

3 June 2018

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Clinical practice. Nephropathy in patients with type 2 diabetes

3 June 2018

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Evolving strategies for renoprotection: diabetic nephropathy

3 June 2018

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Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A.

3 June 2018

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A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type

3 June 2018

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NFAT2 mediates high glucose-induced glomerular podocyte apoptosis through increased Bax expression

3 June 2018

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Approach to the patient with type 2 diabetes and progressive kidney disease

21 January 2018

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SMP-534 ameliorates progression of glomerular fibrosis and urinary albumin in diabetic db/db mice

21 January 2018

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Spironolactone inhibits hyperglycemia-induced podocyte injury by attenuating ROS production.

21 January 2018

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Activation of Galpha q-coupled signaling pathways in glomerular podocytes promotes renal injury

21 January 2018

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Modification of kidney barrier function by the urokinase receptor.

21 January 2018

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Podocyte depletion causes glomerulosclerosis: diphtheria toxin-induced podocyte depletion in rats expressing human diphtheria toxin receptor transgene.

21 January 2018

1 reference

Evolution of renal function abnormalities in the db/db mouse that parallels the development of human diabetic nephropathy

21 January 2018

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12 December 2020

1 reference

12 December 2020

Activation of the Ca(2+)/calcineurin/NFAT2 pathway controls smooth muscle cell differentiation

1 reference

12 December 2020

Diabetic kidney disease: act now or pay later

1 reference

12 December 2020

Amiloride off-target effect inhibits podocyte urokinase receptor expression and reduces proteinuria

1 reference

12 December 2020