Spironolactone inhibits hyperglycemia-induced podocyte injury by attenuating ROS production. (Q53276513)

12 May 2018

title

Spironolactone inhibits hyperglycemia-induced podocyte injury by attenuating ROS production. (English)

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12 May 2018

1 reference

Jiro Toyonaga

1

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12 May 2018

Kazuhiko Tsuruya

2

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12 May 2018

Hirofumi Ikeda

3

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12 May 2018

Hideko Noguchi

4

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12 May 2018

Hideki Yotsueda

5

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12 May 2018

Kiichiro Fujisaki

6

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12 May 2018

Makoto Hirakawa

7

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12 May 2018

Masatomo Taniguchi

8

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12 May 2018

Kohsuke Masutani

9

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12 May 2018

Mitsuo Iida

10

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12 May 2018

language of work or name

English

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publication date

10 January 2011

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12 May 2018

Nephrology Dialysis Transplantation

published in

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12 May 2018

volume

26

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12 May 2018

page(s)

2475-2484

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12 May 2018

issue

8

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12 May 2018

Proteinuria, a target for renoprotection in patients with type 2 diabetic nephropathy: lessons from RENAAL.

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The podocyte's response to injury: role in proteinuria and glomerulosclerosis

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Caught flat-footed: podocyte damage and the molecular bases of focal glomerulosclerosis

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Podocytopenia and disease severity in IgA nephropathy

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Podocyte number predicts long-term urinary albumin excretion in Pima Indians with Type II diabetes and microalbuminuria

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Podocyte number in normotensive type 1 diabetic patients with albuminuria

21 January 2018

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Antiproteinuric effects of mineralocorticoid receptor blockade in patients with chronic renal disease

21 January 2018

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Podocyte as the target for aldosterone: roles of oxidative stress and Sgk1.

21 January 2018

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Spironolactone suppresses inflammation and prevents L-NAME-induced renal injury in rats

21 January 2018

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Angiotensin II and its receptors in the diabetic kidney

21 January 2018

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Spironolactone prevents early renal injury in streptozotocin-induced diabetic rats

21 January 2018

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Reversal of cardiac and renal fibrosis by pirfenidone and spironolactone in streptozotocin-diabetic rats

21 January 2018

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Beneficial effects of spironolactone on glomerular injury in streptozotocin-induced diabetic rats

21 January 2018

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Spironolactone prevents diabetic nephropathy through an anti-inflammatory mechanism in type 2 diabetic rats

21 January 2018

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Beneficial impact of spironolactone in diabetic nephropathy

21 January 2018

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Direct involvement of the receptor-mediated apoptotic pathways in cisplatin-induced renal tubular cell death

21 January 2018

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Accumulation of 8-oxo-deoxyguanosine in cardiovascular tissues with the development of hypertension

21 January 2018

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Beneficial Effects of Estrogens on Indices of Renal Damage in Uninephrectomized SHRsp Rats

21 January 2018

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Activation of Galpha q-coupled signaling pathways in glomerular podocytes promotes renal injury

21 January 2018

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Expression of synaptopodin and GLEPP1 as markers of steroid responsiveness in primary focal segmental glomerulosclerosis

21 January 2018

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Rearrangements of the cytoskeleton and cell contacts induce process formation during differentiation of conditionally immortalized mouse podocyte cell lines.

21 January 2018

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Antioxidant ameliorates cisplatin-induced renal tubular cell death through inhibition of death receptor-mediated pathways

21 January 2018

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Aldosterone stimulates reactive oxygen species production through activation of NADPH oxidase in rat mesangial cells

21 January 2018

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Translocation of Glomerular p47phox and p67phox by Protein Kinase C-β Activation Is Required for Oxidative Stress in Diabetic Nephropathy

21 January 2018

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Increased glomerular cell (podocyte) apoptosis in rats with streptozotocin-induced diabetes mellitus: role in the development of diabetic glomerular disease.

21 January 2018

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Glomerular overproduction of oxygen radicals in Mpv17 gene-inactivated mice causes podocyte foot process flattening and proteinuria: A model of steroid-resistant nephrosis sensitive to radical scavenger therapy.

21 January 2018

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Puromycin aminonucleoside induces oxidant-dependent DNA damage in podocytes in vitro and in vivo.

21 January 2018

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Oxidative stress measurement by in vivo electron spin resonance spectroscopy in rats with streptozotocin-induced diabetes.

21 January 2018

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Accumulation of 8-hydroxy-2'-deoxyguanosine and mitochondrial DNA deletion in kidney of diabetic rats

21 January 2018

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Bone morphogenetic protein-7 delays podocyte injury due to high glucose

21 January 2018

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Hyporeninemic Hypoaldosteronism in Diabetes Mellitus: Studies of the Autonomic Nervous System's Control of Renin Release

21 January 2018

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Effects of spironolactone on systolic blood pressure in experimental diabetic rats

21 January 2018

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sgk is an aldosterone-induced kinase in the renal collecting duct. Effects on epithelial na+ channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFQ750

New insights into the role of serum- and glucocorticoid-inducible kinase SGK1 in the regulation of renal function and blood pressure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFQ750

Epithelial sodium channel regulated by aldosterone-induced protein sgk.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFQ750

Increased expression of mineralocorticoid effector mechanisms in kidney biopsies of patients with heavy proteinuria

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFQ750

High glucose up-regulates ENaC and SGK1 expression in HCD-cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFQ750

High glucose transactivates the EGF receptor and up-regulates serum glucocorticoid kinase in the proximal tubule

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFQ750

Increased expression of NAD(P)H oxidase subunits, NOX4 and p22phox, in the kidney of streptozotocin-induced diabetic rats and its reversibity by interventive insulin treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFQ750

Mechanisms of podocyte injury in diabetes: role of cytochrome P450 and NADPH oxidases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFQ750

Spironolactone exhibits direct renoprotective effects and inhibits renal renin-angiotensin-aldosterone system in diabetic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFQ750

Local renal aldosterone system and its regulation by salt, diabetes, and angiotensin II type 1 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFQ750

Activation of local aldosterone system within podocytes is involved in apoptosis under diabetic conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFQ750

Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFQ750

Statin attenuates high glucose-induced and diabetes-induced oxidative stress in vitro and in vivo evaluated by electron spin resonance measurement

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFQ750

21 January 2018

Identifiers

DOI

10.1093/NDT/GFQ750

1 reference

12 May 2018

PubMed ID

21220752

1 reference

12 May 2018