Ageing increases vulnerability to aβ42 toxicity in Drosophila (Q28727201)

2

0 references

Simon Lovestone

object named as

Simon Lovestone

5

0 references

John Anthony Hardy

4

object named as

John Hardy

0 references

author name string

Iain Rogers

1

0 references

Pedro Martinez

Creative Commons Attribution 4.0 International

3

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language of work or name

English

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publication date

2012

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published in

PLOS One

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volume

7

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issue

7

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page(s)

e40569

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copyright license

start time

12 July 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease

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Dissecting the pathological effects of human Abeta40 and Abeta42 in Drosophila: a potential model for Alzheimer's disease

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Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo

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Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity

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Inhibition of GSK-3 ameliorates Abeta pathology in an adult-onset Drosophila model of Alzheimer's disease

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Abeta42 mutants with different aggregation profiles induce distinct pathologies in Drosophila

3 June 2018

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Limited clearance of pre-existing amyloid plaques after intracerebral injection of Abeta antibodies in two mouse models of Alzheimer disease

3 June 2018

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C. elegans models of age-associated neurodegenerative diseases: lessons from transgenic worm models of Alzheimer's disease

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Ageing and neuronal vulnerability

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Intraneuronal Abeta, non-amyloid aggregates and neurodegeneration in a Drosophila model of Alzheimer's disease.

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Presenilin redistribution associated with aberrant cholesterol transport enhances beta-amyloid production in vivo.

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Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo

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Protein turnover plays a key role in aging

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3 June 2018

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Changes in protein turnover after heat shock are related to accumulation of abnormal proteins in aging Drosophila melanogaster.

3 June 2018

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A model for studying Alzheimer's Abeta42-induced toxicity in Drosophila melanogaster

3 June 2018

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A conditional pan-neuronal Drosophila model of spinocerebellar ataxia 7 with a reversible adult phenotype suitable for identifying modifier genes.

21 January 2018

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Long-lived Drosophila with overexpressed dFOXO in adult fat body

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Metabolic regulation of brain Abeta by neprilysin.

21 January 2018

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Brain aging and Aβ₁₋₄₂ neurotoxicity converge via deterioration in autophagy-lysosomal system: a conditional Drosophila model linking Alzheimer's neurodegeneration with aging

21 January 2018

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Decreasing glutamate buffering capacity triggers oxidative stress and neuropil degeneration in the Drosophila brain.

21 January 2018

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Impairment of proteasome function upon UVA- and UVB-irradiation of human keratinocytes

21 January 2018

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2011 Alzheimer's disease facts and figures

21 January 2018

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2010 Alzheimer's disease facts and figures

27 November 2018

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Aging as a major risk for degenerative diseases of the central nervous system.

27 November 2018

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10.1371/JOURNAL.PONE.0040569

27 November 2018

Identifiers

DOI

1 reference

3088711

ADS bibcode

2012PLoSO...740569R

0 references

3088711

1 reference

1 reference

1 reference