The effect of elevated body mass index on ischemic heart disease risk: causal estimates from a Mendelian randomisation approach (Q28730188)

1

Børge G Nordestgaard

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Anne Tybjærg-Hansen

5

Anne Tybjaerg-Hansen

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Marianne Benn

Marianne Benn

3

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Tom Palmer

Tom M Palmer

2

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Nicholas J. Timpson

Nicholas J Timpson

7

0 references

Jeppe Zacho

4

Creative Commons Attribution 4.0 International

Jeppe Zacho

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language of work or name

English

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publication date

2012

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published in

PLOS MEDICINE

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volume

9

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page(s)

e1001212

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issue

5

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copyright license

start time

1 May 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341326

Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341326

Inactivation of the Fto gene protects from obesity

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341326

The fat mass- and obesity-associated locus and dietary intake in children

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341326

Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341326

Newly identified loci that influence lipid concentrations and risk of coronary artery disease

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341326

The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341326

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341326

Obesity and the risk of myocardial infarction in 27,000 participants from 52 countries: a case-control study

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341326

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341326

‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease?*

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341326

Association between body-mass index and risk of death in more than 1 million Asians

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341326

Using multiple genetic variants as instrumental variables for modifiable risk factors

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341326

Overexpression of Fto leads to increased food intake and results in obesity

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341326

Reverse causation and illness-related weight loss in observational studies of body weight and mortality

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341326

C-reactive protein levels and body mass index: elucidating direction of causation through reciprocal Mendelian randomization

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341326

Hypothalamic-specific manipulation of Fto, the ortholog of the human obesity gene FTO, affects food intake in rats.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341326

The FTO gene is associated with an atherogenic lipid profile and myocardial infarction in patients with type 2 diabetes: a Genetics of Diabetes Audit and Research Study in Tayside Scotland (Go-DARTS) study

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341326

The association between BMI and mortality using offspring BMI as an indicator of own BMI: large intergenerational mortality study

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341326

Genetically elevated C-reactive protein and ischemic vascular disease

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341326

Association of overweight with increased risk of coronary heart disease partly independent of blood pressure and cholesterol levels: a meta-analysis of 21 cohort studies including more than 300 000 persons

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341326

Prospective study of body mass index and risk of stroke in apparently healthy women.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341326

An introduction to instrumental variables for epidemiologists.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341326

A prospective study of body mass index, weight change, and risk of stroke in women.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341326

Body mass index and cardiovascular disease in the Asia-Pacific Region: an overview of 33 cohorts involving 310 000 participants

3 June 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PMED.1001212

Body mass index and ischemic and hemorrhagic stroke: a prospective study in Korean men.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PMED.1001212

The association of body mass index with health outcomes: causal, inconsistent, or confounded?

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PMED.1001212

Correcting biases in estimates of mortality attributable to obesity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PMED.1001212

Association of loss-of-function mutations in the ABCA1 gene with high-density lipoprotein cholesterol levels and risk of ischemic heart disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PMED.1001212

Genetically elevated lipoprotein(a) and increased risk of myocardial infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PMED.1001212

Does greater adiposity increase blood pressure and hypertension risk?: Mendelian randomization using the FTO/MC4R genotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PMED.1001212

Adjusting for treatment effects in studies of quantitative traits: antihypertensive therapy and systolic blood pressure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PMED.1001212

Re: Estimation of Bias in Nongenetic Observational Studies Using “Mendelian Triangulation” by Bautista et al

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PMED.1001212

Underestimation of Risk Associations Due to Regression Dilution in Long-term Follow-up of Prospective Studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PMED.1001212

Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PMED.1001212

C-reactive protein and its role in metabolic syndrome: mendelian randomisation study

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PMED.1001212

Body mass index in adolescence in relation to cause-specific mortality: a follow-up of 230,000 Norwegian adolescents

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PMED.1001212

Causal inference with generalized structural mean models

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PMED.1001212

CANALIZATION OF DEVELOPMENT AND THE INHERITANCE OF ACQUIRED CHARACTERS

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PMED.1001212

Nonfasting Triglycerides and Risk of Myocardial Infarction, Ischemic Heart Disease, and Death in Men and Women

21 January 2018

1 reference

12 December 2020

Body mass index, blood pressure, and mortality from stroke: a nationally representative prospective study of 212,000 Chinese men

1 reference

12 December 2020

A prospective study of obesity and risk of coronary heart disease in women

1 reference

12 December 2020

A FTO variant and risk of acute coronary syndrome

1 reference

12 December 2020

10.1371/JOURNAL.PMED.1001212

Identifiers

DOI

1 reference

1616567

1616567

1 reference

1 reference

1 reference