Pdx1 is post-translationally modified in vivo and serine 61 is the principal site of phosphorylation (Q28730649)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22509401%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

title

Pdx1 is post-translationally modified in vivo and serine 61 is the principal site of phosphorylation (English)

1 reference

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29 January 2020

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3

1 reference

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29 January 2020

Michael Lund Nielsen

4

1 reference

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29 January 2020

author name string

Thomas Frogne

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22509401%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

Kathrine Beck Sylvestersen

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22509401%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

Jacob Hecksher-Sørensen

5

1 reference

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29 January 2020

language of work or name

English

0 references

publication date

11 April 2012

1 reference

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29 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22509401%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

volume

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22509401%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

page(s)

e35233

1 reference

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29 January 2020

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22509401%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

29 January 2020

copyright license

start time

11 April 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum

7 April 2017

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7 April 2017

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Pancreatic and duodenal homeobox 1 (PDX1) phosphorylation at serine-269 is HIPK2-dependent and affects PDX1 subnuclear localization

7 April 2017

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Novel monoclonal antibodies against Pdx1 reveal feedback regulation of Pdx1 protein levels.

3 June 2018

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The transcriptional activity of Neurog3 affects migration and differentiation of ectopic endocrine cells in chicken endoderm.

3 June 2018

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Targeting cyclophilin D and the mitochondrial permeability transition enhances beta-cell survival and prevents diabetes in Pdx1 deficiency

3 June 2018

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CK2 phosphorylation of Pdx-1 regulates its transcription factor activity

3 June 2018

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Glucose regulates steady-state levels of PDX1 via the reciprocal actions of GSK3 and AKT kinases

3 June 2018

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3 June 2018

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Nanofluidic proteomic assay for serial analysis of oncoprotein activation in clinical specimens

3 June 2018

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The 45-kDa form of Pdx-1 does not result from post-translational modifications

3 June 2018

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An illustrated review of early pancreas development in the mouse.

3 June 2018

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3 June 2018

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Phosphorylation marks IPF1/PDX1 protein for degradation by glycogen synthase kinase 3-dependent mechanisms

3 June 2018

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Regulation of the pancreatic duodenal homeobox-1 protein by DNA-dependent protein kinase

3 June 2018

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The pancreatic duodenal homeobox-1 protein (Pdx-1) interacts with histone deacetylases Hdac-1 and Hdac-2 on low levels of glucose

3 June 2018

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PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance

3 June 2018

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The transcription factor PDX-1 is post-translationally modified by O-linked N-acetylglucosamine and this modification is correlated with its DNA binding activity and insulin secretion in min6 beta-cells.

3 June 2018

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3 June 2018

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3 June 2018

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3 June 2018

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3 June 2018

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3 June 2018

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3 June 2018

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3 June 2018

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Differential expression of the insulin gene transcriptional repressor CCAAT/enhancer-binding protein beta and transactivator islet duodenum homeobox-1 in rat pancreatic beta cells during the development of diabetes mellitus

3 June 2018

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Hepatocyte nuclear factor 3beta is involved in pancreatic beta-cell-specific transcription of the pdx-1 gene

3 June 2018

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3 June 2018

1 reference

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The human glucokinase gene beta-cell-type promoter: an essential role of insulin promoter factor 1/PDX-1 in its activation in HIT-T15 cells

3 June 2018

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IPF1, a homeodomain-containing transactivator of the insulin gene

3 June 2018

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XlHbox 8: a novel Xenopus homeo protein restricted to a narrow band of endoderm

3 June 2018

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Endodermal expression of Nkx6 genes depends differentially on Pdx1.

3 June 2018

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Pdx-1 knockdown reduces insulin promoter activity in zebrafish.

21 January 2018

1 reference

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IPF1/PDX1 deficiency and beta-cell dysfunction in Psammomys obesus, an animal With type 2 diabetes

21 January 2018

1 reference

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Zebrafish pdx1 morphant displays defects in pancreas development and digestive organ chirality, and potentially identifies a multipotent pancreas progenitor cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0035233

Glucose regulation of insulin gene expression requires the recruitment of p300 by the beta-cell-specific transcription factor Pdx-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0035233

Regulation of insulin gene transcription by ERK1 and ERK2 in pancreatic beta cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0035233

Stable and functional regeneration of pancreatic beta-cell population in nSTZ-rats treated with tungstate

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0035233

Sumoylation of Pdx1 is associated with its nuclear localization and insulin gene activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0035233

An improved method for three-dimensional reconstruction of protein expression patterns in intact mouse and chicken embryos and organs.

21 January 2018

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Conservation of PDX-1 structure, function, and expression in zebrafish.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3324462

Early-onset type-II diabetes mellitus (MODY4) linked to IPF1

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22509401

12 December 2020

inferred from PubMed ID database lookup

Conditional expression demonstrates the role of the homeodomain transcription factor Pdx1 in maintenance and regeneration of beta-cells in the adult pancreas

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22509401

12 December 2020

inferred from PubMed ID database lookup

Regulation by Per-Arnt-Sim (PAS) kinase of pancreatic duodenal homeobox-1 nuclear import in pancreatic β-cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22509401

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1371/JOURNAL.PONE.0035233

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22509401%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

0 references

release_fltdpn5oqbhwtmt6pgvfw4wqdi

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/fltdpn5oqbhwtmt6pgvfw4wqdi

24 November 2022

mapped directly with Wikidata item

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22509401%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22509401%20AND%20SRC:MED&resulttype=core&format=json