Excess α-synuclein worsens disease in mice lacking ubiquitin carboxy-terminal hydrolase L1 (Q28732131)

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23 January 2020

title

Excess α-synuclein worsens disease in mice lacking ubiquitin carboxy-terminal hydrolase L1 (English)

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23 January 2020

1 reference

1

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23 January 2020

author name string

Tatjana Schweizer

series ordinal

2

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23 January 2020

Peter Schmid

series ordinal

3

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23 January 2020

P Herman van der Putten

series ordinal

4

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23 January 2020

language of work or name

English

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publication date

13 February 2012

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23 January 2020

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23 January 2020

volume

2

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23 January 2020

page(s)

262

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Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported

23 January 2020

copyright license

start time

13 February 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Loss of Uch-L1 and Uch-L3 leads to neurodegeneration, posterior paralysis and dysphagia

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Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

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Substrate binding and catalysis by ubiquitin C-terminal hydrolases: identification of two active site residues

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The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase

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The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

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Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

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Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

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A Drosophila model of Parkinson's disease

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Ubiquitin carboxyl-terminal hydrolase L1 is required for maintaining the structure and function of the neuromuscular junction

7 April 2017

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Regulation of synaptic structure by ubiquitin C-terminal hydrolase L1.

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Membrane-associated farnesylated UCH-L1 promotes alpha-synuclein neurotoxicity and is a therapeutic target for Parkinson's disease

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Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo.

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Differential effects of Usp14 and Uch-L1 on the ubiquitin proteasome system and synaptic activity.

3 June 2018

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Aberrant interaction between Parkinson disease-associated mutant UCH-L1 and the lysosomal receptor for chaperone-mediated autophagy

3 June 2018

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3 June 2018

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3 June 2018

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The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility

3 June 2018

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Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice

3 June 2018

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beta-Synuclein inhibits alpha-synuclein aggregation: a possible role as an anti-parkinsonian factor

3 June 2018

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Intragenic deletion in the gene encoding ubiquitin carboxy-terminal hydrolase in gad mice

3 June 2018

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The ubiquitin pathway in Parkinson's disease

3 June 2018

1 reference

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NACP, a presynaptic protein, immunoreactivity in Lewy bodies in Parkinson's disease

3 June 2018

1 reference

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Abnormal accumulation of NACP/alpha-synuclein in neurodegenerative disorders

3 June 2018

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Astrocytes: form, functions, and roles in disease

3 June 2018

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Ion activities and potassium uptake mechanisms of glial cells in guinea-pig olfactory cortex slices

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278044

Ubiquitin carboxyl-terminal hydrolase (PGP 9.5) is selectively present in ubiquitinated inclusion bodies characteristic of human neurodegenerative diseases

3 June 2018

1 reference

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Pathological findings in idiopathic orthostatic hypotension. Its relationship with Parkinson's disease

3 June 2018

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UCHL-1 is not a Parkinson's disease susceptibility gene

21 January 2018

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UCHL1 is a Parkinson's disease susceptibility gene

21 January 2018

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A polymorphic variation of serine to tyrosine at codon 18 in the ubiquitin C-terminal hydrolase-L1 gene is associated with a reduced risk of sporadic Parkinson's disease in a Japanese population

21 January 2018

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Dopaminergic neuronal loss in transgenic mice expressing the Parkinson's disease-associated UCH-L1 I93M mutant.

21 January 2018

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Reduced ubiquitin C-terminal hydrolase-1 expression levels in dementia with Lewy bodies.

21 January 2018

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Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases

21 January 2018

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Altered proteasomal function in sporadic Parkinson's disease

21 January 2018

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Alpha-synuclein potentiates Ca2+ influx through voltage-dependent Ca2+ channels

21 January 2018

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Forebrain-specific glutamate receptor B deletion impairs spatial memory but not hippocampal field long-term potentiation.

21 January 2018

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DJ-1 and UCH-L1 gene activity patterns in the brains of controls, Parkinson and schizophrenia patients and in rodents

21 January 2018

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Astrocytes protect neurons from nitric oxide toxicity by a glutathione-dependent mechanism

21 January 2018

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21 January 2018

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Neuropathology in mice expressing human alpha-synuclein

27 November 2018

1 reference

12 December 2020

PGP9.5 as a marker for invasive colorectal cancer

1 reference

12 December 2020

Accumulation of beta- and gamma-synucleins in the ubiquitin carboxyl-terminal hydrolase L1-deficient gad mouse

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12 December 2020

Axonal degeneration promotes abnormal accumulation of amyloid beta-protein in ascending gracile tract of gracile axonal dystrophy (GAD) mouse

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12 December 2020

Identifiers

DOI

10.1038/SREP00262

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22355774%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

23 January 2020

0 references

1 reference

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23 January 2020

PubMed publication ID

22355774

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22355774%20AND%20SRC:MED&resulttype=core&format=json