Residues 190-210 of human topoisomerase I are required for enzyme activity in vivo but not in vitro (Q28910347)

7 March 2017

title

Residues 190-210 of human topoisomerase I are required for enzyme activity in vivo but not in vitro (English)

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7 March 2017

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GOA release 2020-03-11

supercoiled DNA binding

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GOA release 2020-03-11

3

Fritz Boege

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author name string

Morten O. Christensen

series ordinal

1

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7 March 2017

Hans U. Barthelmes

series ordinal

2

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7 March 2017

Christian Mielke

series ordinal

4

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7 March 2017

language of work or name

English

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publication date

15 December 2003

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7 March 2017

published in

Nucleic Acids Research

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7 March 2017

volume

31

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7 March 2017

issue

24

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7 March 2017

page(s)

7255–7263

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Nonlinear partial differential equations and applications: The mechanism of topoisomerase I poisoning by a camptothecin analog

7 March 2017

cites work

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The topoisomerase I-binding RING protein, topors, is associated with promyelocytic leukemia nuclear bodies

16 March 2017

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Subnuclear distribution of topoisomerase I is linked to ongoing transcription and p53 status

16 March 2017

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16 March 2017

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A novel nuclear localization signal in human DNA topoisomerase I

16 March 2017

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Role for nucleolin/Nsr1 in the cellular localization of topoisomerase I.

16 March 2017

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PSF/p54(nrb) stimulates "jumping" of DNA topoisomerase I between separate DNA helices

16 March 2017

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Novel insights into catalytic mechanism from a crystal structure of human topoisomerase I in complex with DNA

16 March 2017

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Interaction between human topoisomerase I and a novel RING finger/arginine-serine protein

16 March 2017

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The RNA-splicing factor PSF/p54 controls DNA-topoisomerase I activity by a direct interaction

16 March 2017

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A model for the mechanism of human topoisomerase I

16 March 2017

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Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA

16 March 2017

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Cell cycle-coupled relocation of types I and II topoisomerases and modulation of catalytic enzyme activities

16 March 2017

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The domain organization of human topoisomerase I

16 March 2017

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Biochemical and biophysical analyses of recombinant forms of human topoisomerase I

16 March 2017

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Identification of a nucleolin binding site in human topoisomerase I

16 March 2017

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High mobility of proteins in the mammalian cell nucleus

16 March 2017

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The N-terminal domain anchors human topoisomerase I at fibrillar centers of nucleoli and nucleolar organizer regions of mitotic chromosomes

7 April 2017

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Changes in mobility account for camptothecin-induced subnuclear relocation of topoisomerase I.

3 June 2018

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Topoisomerase I-mediated DNA damage

3 June 2018

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Stabilized, long-term expression of heterodimeric proteins from tricistronic mRNA.

3 June 2018

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p53 dependence of topoisomerase I recruitment in vivo.

3 June 2018

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A functional linker in human topoisomerase I is required for maximum sensitivity to camptothecin in a DNA relaxation assay

3 June 2018

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Expression, purification and DNA-cleavage activity of recombinant 68-kDa human topoisomerase I-target for antitumor drugs.

3 June 2018

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Characterization of topotecan-mediated redistribution of DNA topoisomerase I by digital imaging microscopy

3 June 2018

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In vivo sequencing of camptothecin-induced topoisomerase I cleavage sites in human colon carcinoma cells

3 June 2018

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Subcellular redistribution of DNA topoisomerase I in anaplastic astrocytoma cells treated with topotecan

3 June 2018

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Studies on the role of topoisomerases in general, gene- and strand-specific DNA repair

3 June 2018

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Phosphorylation of DNA topoisomerase I is increased during the response of mammalian cells to mitogenic stimuli

3 June 2018

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Eukaryotic DNA topoisomerases I.

3 June 2018

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Involvement of DNA topoisomerase I in transcription of human ribosomal RNA genes.

3 June 2018

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DNA topoisomerase poisons as antitumor drugs

3 June 2018

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Phosphorylation of mammalian DNA topoisomerase I and activation by protein kinase C.

3 June 2018

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Residues within the N-terminal Domain of Human Topoisomerase I Play a Direct Role in Relaxation*

3 June 2018

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Modulation of DNA Topoisomerase I Activity byp53

26 November 2018

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Identification of an N-terminal domain of eukaryotic DNA topoisomerase I dispensable for catalytic activity but essential for in vivo function

26 November 2018

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Functional expression of human DNA topoisomerase I and its subcellular localization in HeLa cells

26 November 2018

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12 December 2020

Reconstitution of enzymatic activity by the association of the cap and catalytic domains of human topoisomerase I

1 reference

12 December 2020

On the mechanism of topoisomerase I inhibition by camptothecin: evidence for binding to an enzyme-DNA complex

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12 December 2020

Interaction between replication forks and topoisomerase I-DNA cleavable complexes: studies in a cell-free SV40 DNA replication system

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12 December 2020

DNA recombinase activity of eukaryotic DNA topoisomerase I; effects of camptothecin and other inhibitors

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12 December 2020

Human DNA topoisomerase I-mediated cleavages stimulated by ultraviolet light-induced DNA damage

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12 December 2020

Structural insights into the function of type IB topoisomerases

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12 December 2020

Camptothecin-stabilised topoisomerase I-DNA complexes in leukaemia cells visualised and quantified in situ by the TARDIS assay (trapped in agarose DNA immunostaining)

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12 December 2020

Identifiers

DOI

10.1093/NAR/GKG927

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