FGFR3 signaling induces a reversible senescence phenotype in chondrocytes similar to oncogene-induced premature senescence (Q28975455)

21 March 2017

title

FGFR3 signaling induces a reversible senescence phenotype in chondrocytes similar to oncogene-induced premature senescence (English)

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21 March 2017

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8

Alois Kozubik

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21 March 2017

Pavel Krejci

1

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21 March 2017

Jirina Prochazkova

2

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21 March 2017

Jiri Smutny

3

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21 March 2017

Katarina Chlebova

4

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21 March 2017

Patricia Lin

5

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21 March 2017

Anie Aklian

6

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21 March 2017

Vitezslav Bryja

7

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21 March 2017

William R. Wilcox

9

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21 March 2017

publication date

1 July 2010

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21 March 2017

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21 March 2017

volume

47

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21 March 2017

issue

1

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21 March 2017

page(s)

102–110

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Sustained phosphorylation of mutated FGFR3 is a crucial feature of genetic dwarfism and induces apoptosis in the ATDC5 chondrogenic cell line via PLCgamma-activated STAT1

21 March 2017

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23 March 2017

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23 March 2017

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23 March 2017

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23 March 2017

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Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis

23 March 2017

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Activating mutations in FGFR3 and HRAS reveal a shared genetic origin for congenital disorders and testicular tumors

23 March 2017

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Analysis of STAT1 activation by six FGFR3 mutants associated with skeletal dysplasia undermines dominant role of STAT1 in FGFR3 signaling in cartilage

3 June 2018

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FGFR3 promotes synchondrosis closure and fusion of ossification centers through the MAPK pathway

3 June 2018

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STAT1 and STAT3 do not participate in FGF-mediated growth arrest in chondrocytes

3 June 2018

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3 June 2018

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3 June 2018

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Oncogene-induced senescence pathways weave an intricate tapestry

3 June 2018

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Suppressors of cytokine signaling (SOCS) 1 and SOCS3 interact with and modulate fibroblast growth factor receptor signaling

3 June 2018

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Constitutive activation of MKK6 in chondrocytes of transgenic mice inhibits proliferation and delays endochondral bone formation

3 June 2018

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Interaction of fibroblast growth factor and C-natriuretic peptide signaling in regulation of chondrocyte proliferation and extracellular matrix homeostasis

3 June 2018

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FGF2 inhibits proliferation and alters the cartilage-like phenotype of RCS cells

3 June 2018

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Constitutive activation of MEK1 in chondrocytes causes Stat1-independent achondroplasia-like dwarfism and rescues the Fgfr3-deficient mouse phenotype

3 June 2018

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A network of transcriptional and signaling events is activated by FGF to induce chondrocyte growth arrest and differentiation

3 June 2018

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Induction of extracellular matrix-remodeling genes by the senescence-associated protein APA-1

3 June 2018

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FGF signaling targets the pRb-related p107 and p130 proteins to induce chondrocyte growth arrest

3 June 2018

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Identification of novel candidates for replicative senescence by functional proteomics.

3 June 2018

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Induction of chondrocyte growth arrest by FGF: transcriptional and cytoskeletal alterations

3 June 2018

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Identification of a candidate tumor-suppressor gene specifically activated during Ras-induced senescence.

3 June 2018

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A Ser(365)-->Cys mutation of fibroblast growth factor receptor 3 in mouse downregulates Ihh/PTHrP signals and causes severe achondroplasia

3 June 2018

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Stress signals utilize multiple pathways to stabilize p53

3 June 2018

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Clinical spectrum of fibroblast growth factor receptor mutations

3 June 2018

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A Lys644Glu substitution in fibroblast growth factor receptor 3 (FGFR3) causes dwarfism in mice by activation of STATs and ink4 cell cycle inhibitors

3 June 2018

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Molecular, radiologic, and histopathologic correlations in thanatophoric dysplasia

3 June 2018

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Cloning and identification of genes that associate with mammalian replicative senescence

3 June 2018

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Replicative senescence, aging and growth-regulatory transcription factors

3 June 2018

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The role of mesenchyme-like tissue in the pathogenesis of thanatophoric dysplasia

3 June 2018

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FGFR3 and PIK3CA mutations are involved in the molecular pathogenesis of solar lentigo

3 June 2018

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Sustained ERK1/2 but not STAT1 or 3 activation is required for thanatophoric dysplasia phenotypes in PC12 cells

26 November 2018

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Induction of ser15 and lys382 modifications of p53 by blockage of transcription elongation.

26 November 2018

1 reference

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STAT1 mediates the increased apoptosis and reduced chondrocyte proliferation in mice overexpressing FGF2

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087869

Highly activated Fgfr3 with the K644M mutation causes prolonged survival in severe dwarf mice

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087869

Restrained chondrocyte proliferation and maturation with abnormal growth plate vascularization and ossification in human FGFR-3(G380R) transgenic mice

26 November 2018

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12 December 2020

Ectopic expression of fibroblast growth factor receptor 3 promotes myeloma cell proliferation and prevents apoptosis

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12 December 2020

Up-regulation of caveolin attenuates epidermal growth factor signaling in senescent cells

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12 December 2020

Fibroblast growth factor inhibits chondrocytic growth through induction of p21 and subsequent inactivation of cyclin E-Cdk2

1 reference

12 December 2020

Overexpression of CNP in chondrocytes rescues achondroplasia through a MAPK-dependent pathway

1 reference

12 December 2020

Activation of the ERK1/2 and p38 mitogen-activated protein kinase pathways mediates fibroblast growth factor-induced growth arrest of chondrocytes

1 reference

12 December 2020

Fibroblast growth factor receptor 3 mutations promote apoptosis but do not alter chondrocyte proliferation in thanatophoric dysplasia

1 reference

12 December 2020

1 reference

12 December 2020

10.1016/J.BONE.2010.03.021

Identifiers

DOI

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21 March 2017

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